Effectiveness of sucrose analgesia in newborns undergoing painful medical procedures

Taddio, Anna; Shah, Vibhuti; Hancock, Rebecca; Smith, Rebecca P.; Stephens, Derek; Atenafu, Eshetu G.; Beyene, Joseph; Koren, Gideon; Stevens, Bonnie; Katz, Joel

doi:10.1503/cmaj.071734

Cited by 94 publications

(82 citation statements)

References 29 publications

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“…48 The compelling evidence from these early studies demonstrating profound effects of oral sucrose in inducing and maintaining a calm yet awake state in newborn infants and reducing behavioral responses during painful procedures compared with water and less sweet solutions, set the stage for an abundance of subsequent studies, reviews, and systematic reviews. 1 3 An exception to these findings was when sucrose had minimal effects compared with water when given within hours of birth before intramuscular injection of vitamin K. 49 This finding concurred with an animal model study in which sucrose had no effect in reducing responses to thermal stimuli in newborn rats on the first day of life. 32 One explanation proposed for this more modest effect of sweet taste in the first 12 hours of birth may be due to high circulating serum b endorphins negating further increase in response to sweet taste.…”

Section: Human Model Studiesmentioning

confidence: 53%

Sucrose for Procedural Pain Management in Infants

2012

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The use of oral sucrose has been the most extensively studied pain intervention in newborn care to date. More than 150 published studies relating to sweet-taste-induced calming and analgesia in human infants have been identified, of which 100 (65%) include sucrose. With only a few exceptions, sucrose, glucose, or other sweet solutions reduced pain responses during commonly performed painful procedures in diverse populations of infants up to 12 months of age. Sucrose has been widely recommended for routine use during painful procedures in newborn and young infants, yet these recommendations have not been translated into consistent use in clinical practice. One reason may be related to important knowledge and research gaps concerning analgesic effects of sucrose. Notably, the mechanism of sweet-taste-induced analgesia is still not precisely understood, which has implications for using research evidence in practice. The aim of this article is to review what is known about the mechanisms of sucrose-induced analgesia; highlight existing evidence, knowledge gaps, and current controversies; and provide directions for future research and practice. Pediatrics 2012;130:918-925

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Section: Human Model Studiesmentioning

confidence: 53%

Sucrose for Procedural Pain Management in Infants

2012

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“…The nurses in this study reported implementing swaddling and non-nutritive sucking (without oral sucrose) as preferred methods of non-pharmacological pain management intervention. Taddio et al (2008) proved the effectiveness of this intervention, and addressed concerns related to the effect of oral sucrose on neonatal glucose homeostasis, finding that low doses did not increase the neonates' blood glucose.…”

Section: Discussionmentioning

confidence: 99%

Knowledge, attitudes and practices of neonatal staff concerning neonatal pain management

Khoza

Tjale

2014

curationis

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Background: Neonatal pain management has received increasing attention over the past four decades. Research into the effects of neonatal pain emphasises the professional, ethical and moral obligations of staff to manage pain for positive patient outcomes. However, evaluation studies continuously report evidence of inadequate neonate pain management and a gap between theory and practice.Objective: This study reviewed current practice in neonatal pain management to describe the knowledge, attitudes and practices of nurses and doctors regarding pain management for neonates in two academic hospitals.Method: A non-experimental, prospective quantitative survey, the modified Infant Pain Questionnaire, was used to collect data from 150 nurses and doctors working in the neonatal wards of two academic hospitals in central Gauteng.Results: The response rate was 35.33% (n = 53), most respondents being professional nurses (88.68%; n = 47) working in neonatal intensive care units (80.77%; n = 42); 24 (45.28%) had less than 5 years’ and 29 respondents 6 or more years’ working experience in neonatal care. A review of pain management in the study setting indicated a preference for pharmacological interventions to relieve moderate to severe pain. An association (p < 0.05) was found between pain ratings on 5 procedures and frequency of administration of pharmacological pain management. Two-thirds of respondents (64%) reported that there were no pain management guidelines in the neonatal wards in which they worked.Conclusion: The interventions to manage moderate neonatal pain are in line with international guidelines. However, neonatal pain management may not occur systematically based on prior assessment of neonatal pain, choice of most appropriate intervention and evaluation. This study recommends implementation of a guideline to standardise practice and ensure consistent and adequate pain management in neonates.

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“…Diferent concentrations and dose were examined and showed to have a pain relieving efect. The most widely used sweet solution is sucrose [17]. Glucose is the second most commonly used solution, as it is available as prepared solution at clinics and hospitals [9].…”

Section: Sweet Solutions In the Clinical Setings And Guidelinesmentioning

confidence: 99%