Effectiveness of the 2010–2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case–case comparison, case-control study

Puig-Barberà, Joan; Díez‐Domingo, Javier; Arnedo-Pena, Alberto; Ruiz‐García, Montserrat; Perez‐Vilar, Silvia; Micó-Esparza, José Luis; Belenguer-Varea, Ángel; Carratalá‐Munuera, C; Gil-Guillén, Vicente Francisco; Schwarz-Chavarri, H.

doi:10.1016/j.vaccine.2012.07.006

Cited by 42 publications

(32 citation statements)

References 43 publications

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“…22,23 Recent Spanish observational studies found that vaccine effectiveness in preventing laboratory-confirmed influenza-related hospitalizations ranged from 31 to 59% in patients aged 65 y. [24][25][26] Influenza vaccination policy in most developed countries, therefore, targets people aged 65 y as part of the effort to reduce the burden of mortality and disability in this population.…”

Section: Discussionmentioning

confidence: 99%

Costs associated with influenza-related hospitalization in the elderly

Torner

Navas²,

Soldevila

et al. 2016

Human Vaccines & Immunotherapeutics

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Seasonal influenza epidemics remain a considerable burden in adults, especially in those at higher risk of complications. The aim of this study was to determine the costs associated with influenza-related hospitalization in patients aged 65 y admitted to 20 hospitals from 7 Spanish regions during the 2013-14 and 2014-15 influenza seasons. Bivariate analysis was used to compare costs in vaccinated and unvaccinated cases. Costs were calculated according to the Spanish National Health System diagnosisrelated group tables for influenza and other respiratory system conditions (GRD 89 and GRD 101). A total of 728 confirmed influenza cases were recorded: 52.9% were male, 46.7% were aged 75-84 years, and 49.3% received influenza vaccine 15 d prior to hospital admission. Influenza-related mean hospitalization costs (MHC) were € 1,184,808 in unvaccinated and € 1,152,333 in vaccinated cases (2.75% lower). Influenza vaccination showed significant protection against ICU admission (OR 0.35, 95%CI 0.21-0.59; p < 0001); mechanical ventilation (OR 0.56, 95%CI 0.39-0.80; p D 0.002); secondary bacterial pneumonia (OR 0.61,; p D 0.04) and a higher degree of dependence (OR 0.74, p D 0.04). No association was observed for the Charlson comorbidity index or the mean hospital stay. Although influenza vaccination of the elderly may not achieve significant savings in mean hospitalization costs, it may lessen the degree of severity and avoid complications.

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Section: Discussionmentioning

confidence: 99%

Costs associated with influenza-related hospitalization in the elderly

Torner

Navas²,

Soldevila

et al. 2016

Human Vaccines & Immunotherapeutics

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“…In studies evaluating Northern Hemisphere 2010–2011 IIV against influenza using primarily outpatient case and control patients, point estimates of VE among persons ≥60 years ranged from no significant effectiveness likely due to small sample sizes to approximately 70% effectiveness 8,11,12. In test-negative case–control studies evaluating the same vaccine strain composition against influenza-associated hospitalization in persons ≥60 years, point estimates ranged from 52% in a study using hospitalized case patients and outpatient control patients10 to 59% in a study using hospitalized control patients,9 consistent with our VE estimate.…”

Section: Discussionmentioning

confidence: 99%

“…Low vaccination uptake is a major challenge to using a test-negative case–control design to estimate influenza VE among target groups in countries with new influenza vaccination programs. Second, some case–control studies of IIV effectiveness define control patients as those who are negative for influenza viruses but positive for other respiratory viruses to control for respiratory specimen quality and reduce case misclassification due to false-negative influenza test results 9,16. Despite extensive testing for other respiratory viruses, we were unable to use this approach because there were too few patients with respiratory specimens negative for influenza but positive for other respiratory viruses.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the 2010 and 2011 Southern Hemisphere trivalent inactivated influenza vaccines against hospitalization with influenza‐associated acute respiratory infection among Thai adults aged ≥50 years

Dawood

Prapasiri

Areerat

et al. 2014

Influenza Resp Viruses

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BackgroundInactivated influenza vaccine (IIV) effectiveness has been evaluated among older adults in high-income countries, but data on IIV effectiveness in low- and middle-income countries remain sparse. We conducted a test-negative case–control analysis to estimate 2010 and 2011 trivalent IIV effectiveness against hospitalization with influenza-associated acute respiratory infection (ARI) among persons aged ≥50 years in rural Thailand.MethodsDuring 2010–2011, active surveillance for ARI hospitalization was conducted in two provinces; patients were tested for influenza viruses by real-time RT-PCR. Vaccination status was obtained from vaccine registries. Case and control patients were patients with nasopharyngeal swabs positive and negative for influenza viruses, respectively. Vaccine effectiveness (VE) was estimated for the 6 months after vaccination began. Logistic regression was used to evaluate the association between case status and vaccination while adjusting for age, province, medical conditions, and time.ResultsDuring 2010–2011, there were 1545 patients with ARI, of whom 279 (18%) were influenza-positive case patients and 1266 (82%) were influenza-negative control patients. Of the 279 case patients, 247 (89%) had influenza A and 32 (11%) had influenza B. Fourteen of 279 (5%) case patients and 108 of 1266 (9%) control patients were vaccinated against influenza. The unadjusted IIV effectiveness against hospitalization with influenza-associated ARI was 43% (95% CI: 0–68%); adjusted VE was 47% (95% CI: 5–71%).ConclusionThe 2010 and 2011 IIVs were moderately effective against hospitalization with influenza-associated ARI among Thais aged ≥50 years, but IIV coverage was low. Additional efforts are warranted in Thailand to improve IIV uptake in this target group.

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“…There were some reports on the clinical effectiveness of the 2010-2011 influenza vaccine in a relatively small population of children (2)(3)(4)(5).…”

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confidence: 99%

Case-Control Study of the Effectiveness of the 2010-2011 Seasonal Influenza Vaccine for Prevention of Laboratory-Confirmed Influenza Virus Infection in the Korean Adult Population

Choi

Noh

Seo

et al. 2013

Clin Vaccine Immunol

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We evaluated the effectiveness of the 2010-2011 seasonal influenza vaccine for preventing laboratory-confirmed influenza in a South Korean population. A retrospective case-control study was conducted among patients who visited selected hospitals from September 2010 to May 2011. A total of 483 laboratory-confirmed influenza patients were included in the analysis as case subjects. For each case patient, two types of control patients were chosen at a ratio of 1:1:1, and 966 control subjects were selected. Vaccine effectiveness (VE) was defined as 100 ؋ (1 ؊ odds ratio for influenza in vaccinated versus nonvaccinated persons). The VE of the 2010-2011 seasonal influenza vaccine was 49.5% to 45.8% for both influenza A and B viruses and 50.8% to 47.2% for influenza A virus, according to the control type. The age-specific adjusted VE was 50.8% to 46.5% among subjects aged 19 to 49 years and 58.7% to 63.3% among those aged 50 to 64 years, according to the control type. Statistically significant VE was not found among those aged >65 years or against influenza B virus. The 2010-2011 seasonal influenza vaccine was effective for preventing laboratory-confirmed influenza, especially for influenza A virus, in a South Korean population. Evidence of the effectiveness of the influenza vaccine in older adults or against influenza B virus was not found.

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Effectiveness of the 2010–2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case–case comparison, case-control study

Abstract: Influenza vaccination was associated with a significant reduction on the risk of confirmed influenza hospitalization, irrespective of age and high-risk conditions.

Cited by 42 publications

References 43 publications

Costs associated with influenza-related hospitalization in the elderly

Costs associated with influenza-related hospitalization in the elderly

Effectiveness of the 2010 and 2011 Southern Hemisphere trivalent inactivated influenza vaccines against hospitalization with influenza‐associated acute respiratory infection among Thai adults aged ≥50 years

Case-Control Study of the Effectiveness of the 2010-2011 Seasonal Influenza Vaccine for Prevention of Laboratory-Confirmed Influenza Virus Infection in the Korean Adult Population

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