Effectiveness of the healing rate of sickle wounds with musa acuminata colla genome AA extract gel on rattus novergicus

Abstract

Background: Wounds occur due to the damage of the body's network caused by several factors. To prevent severe bleeding or complications, it requires treatment that can assist in the healing process. One of the treatments is the use of natural substances containing flavonoids. Flavonoids can be naturally found in plants, one of which is in Musa Acuminata Colla genom AA. The gel preparation of Musa Acuminata Colla genom AA extract has the advantage of easy application, practicality, and maintaining skin hydration. Purpose: To determine the effect of Musa Acuminata Colla genom AA content on the speed of healing incision wounds. Method: Experimental with completely randomized design. Musa Acuminata Colla genome AA extract was processed through maceration with 70% ethanol. The formula contains methyl paraben, propyl paraben, propylene glycol, HPMC with varying concentrations: F1 (10%), F2 (20%), and F3 (40%). Evaluation of the physical properties of the preparation includes organoleptic examination, drying time, macroscopic examination, and data analysis using Welch One Way ANOVA and Howell's Post Hoc Games. Results: The results of the Welch One Way ANOVA showed that the experimental group had a significant effect on days 3, 5, and 7 after injury. The results of the Howell Post Hoc Games showed a significant difference between the control and experimental groups on the same day. Conclusion: Musa Acuminata Colla Extract AA genome 40% has the effect of increasing the re-epithelialization process on wound healing, and its effectiveness is almost equivalent to Loematuell branded wound care tools.