Effectiveness of the supraomohyoid neck dissection in clinically N0 neck patients with squamous cell carcinoma of buccal mucosa and gingivobuccal sulcus

Rahamthulla, S A K Uroof; Priya, P Vani; Hussain, Showket; Nasyam, Fazil Arshad; Akifuddin, Syed; Srinivas, Velpula Sasidhar

doi:10.4103/2231-0762.155740

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…It plays a significant part in tumorigenesis and progression. This includes tumor growth, migration, invasion and tumor metastasis [15,29,30]. MMP-12 is recommended as a diagnostic biomarker for OSCC due to its significant sensitivity and specificity [15].…”

Section: Discussionmentioning

confidence: 99%

Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma

et al. 2021

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Background Oral squamous cell carcinoma is a global threat and accounts for approximately 90% of malignant oral lesions. The emergence of oral carcinoma is linked to precancerous lesions, which act as precursors of the disease. Matrix metalloproteinases appear to play a significant role in the pathogenesis of both precancerous conditions and oral malignancies due to their participation in remodeling of the extracellular matrix. Methodology This is an analytical study conducted at Dow University of Health Sciences, Pakistan. Unstimulated saliva samples were collected from healthy, oral submucous fibrosis and oral squamous cell carcinoma patients. The level of MMP-12 was estimated using enzyme-linked immunosorbent assay. One-way Analysis of variance was run to determine if MMP-12 levels differ between the three groups, which was preceded by post hoc Tuckey test. MMP-12 cut off values were determined using Receiver operating characteristic curve. Results A significant difference in salivary MMP-12 expression was observed in OSF and OSCC (p < 0.001). The expression of salivary MMP-12 was higher in OSF and OSCC patients as compared to the healthy group (p < 0.001). The mean MMP-12 expression in OSCC appeared higher than in OSF cases (p < 0.05). MMP-12 value of $$\ge$$ ≥ 4.05 ng/ml and $$\ge$$ ≥ 4.20 ng/ml is predictive of OSF and OSCC respectively, with 100% sensitivity and specificity (p < 0.001). Conclusion Increased expression of MMP-12 appears as the healthy patient advances to OSF and OSCC. The study results also demonstrate higher MMP-12 expression in OSCC patients as compared to OSF. Therefore, the estimation of salivary MMP-12 serves as a valuable non-invasive early diagnostic tool in diagnosing oral submucous fibrosis and oral squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma

et al. 2021

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“…Histologically, squamous type OSCC is the most prevalent cancer of oral cavity causing about 85–90% cancer burden in Pakistani population 11. The pursuit of a biomarker for the timely and precise detection of OSCC is ever increasing.…”

Section: Discussionmentioning

confidence: 99%

Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma

et al. 2019

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Objective: To estimate the serum levels of matrix metalloproteinases in oral squamous cell carcinoma patients and in healthy subjects. Methods: In this observational study, biopsy diagnosed oral squamous cell carcinoma patients (n= 38) were recruited from Mayo Hospital, Lahore during 2016 to 2017. Age and gender matched Controls (n= 38) were also included. Venous blood sample of each participant was drawn, serum separated and the levels of matrix metalloproteinases were measured by multiplex ELISA. Results: Serum levels of MMP-1, -8, -10, -12 and -13 in OSCC patients showed statistically significant increase as compared to control group (p < 0.01). The MMP-12 predicted the presence of OSCC with highest AUC of 0.836 (95% CI [0.733 to 0.911]) for sensitivity and specificity of 80% and 78.9%, respectively for a cut-off value of 16.13 pg/ml. Conclusions: MMP-12 has been found to have significant sensitivity and specificity to qualify as a diagnostic biomarker. How to cite this:Choudhry N, Sarmad S, Waheed NA, Gondal AJ. Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma. Pak J Med Sci. 2019;35(1):252-256. doi: https://doi.org/doi.org/10.12669/pjms.35.1.68 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…It plays a signi cant part in tumorigenesis and progression. This includes tumour growth, migration, invasion and tumour metastasis [12,25,26]. MMP-12 is recommended as a diagnostic biomarker for OSCC due to its signi cant sensitivity and speci city [12].…”

Section: Sample Collectionmentioning

confidence: 99%

Estimation of Salivary Matrix Metalloproteinases- 12 (MMP- 12) Levels Among Patients Presenting With Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma

Saleem

Shaikh

Zaman

et al. 2021

Preprint

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Background:Oral squamous cell carcinoma is a global threat and accounts for approximately 90% of malignant oral lesions. The emergence of oral carcinoma is linked to precancerous lesions which act as precursors of the disease. Matrix metalloproteinases appear to play a significant role in the pathogenesis of both precancerous conditions and oral malignancies due to their participation in the remodelling of the extracellular matrix.Methodology:This is an analytical study conducted at Dow University of Health Sciences, Karachi, Pakistan. Unstimulated saliva samples were collected from healthy, oral submucous fibrosis and oral squamous cell carcinoma patients. The level of MMP-12 was estimated using enzyme-linked immunosorbent assay (ELISA). One-way analysis of variance (ANOVA) was run to determine if MMP-12 levels differ between cases and controls which was preceded by posthoc Tuckey test.ResultsA significant difference in salivary MMP-12 expression was observed in OSF and OSCC. The expression of salivary MMP-12 was higher in cases compared to controls. The mean MMP-12 expression in OSCC was found higher than in OSF cases.ConclusionMMP-12 expression increases as the healthy patient advances to OSF and OSCC. The study results also demonstrate higher MMP-12 expression in OSCC patients as compared to OSF. Therefore, estimation of salivary MMP-12 serves as a useful non-invasive early diagnostic tool in the diagnosis of oral submucous fibrosis and oral squamous cell carcinoma.

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Effectiveness of the supraomohyoid neck dissection in clinically N0 neck patients with squamous cell carcinoma of buccal mucosa and gingivobuccal sulcus

Cited by 3 publications

References 16 publications

Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma

Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma

Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma

Estimation of Salivary Matrix Metalloproteinases- 12 (MMP- 12) Levels Among Patients Presenting With Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma

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