Effectiveness of Topical Anesthetics in Pain Management for Dermal Injuries: A Systematic Review

Navarro-Rodriguez, Juan Manuel; Suárez-Serrano, Carmen; Martín-Valero, Rocío; Marcén-Román, Yolanda; de-la-Casa-Almeida, María

doi:10.3390/jcm10112522

Cited by 5 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, any new drugs that reduce pain intensity during injection will augment dental and oral health compliance [ 56 ]. All the present topical anesthesia cannot relieve the pain entirely [ 57 ], and patients complain of mild to moderate pain [ 58 ]. These problems have led to the need for newer and more effective drugs.…”

Section: Discussionmentioning

confidence: 99%

Anesthetic Effect of 2% Amitriptyline Versus 2% Lidocaine: A Comparative Evaluation

Patel¹,

Urolagin²,

Haq³

et al. 2023

Cureus

View full text Add to dashboard Cite

Introduction A common dental problem is the fear of pain during needle prick for giving local anesthesia (LA). The needle prick pain during dental procedures often varies with sex and age. Perception of pain depends on various factors, which can be psychological and biological. This perception of pain may change the behavior of patients toward dental treatments. Traditionally, lidocaine gel formulation was utilized before the parenteral dosage form. The lidocaine gel formulation is considered the drug of choice for LA in dental surgery. Currently, amitriptyline has been utilized in dental practice because of its beneficial pharmacology. Hence, the present study has been undertaken to compare the anesthetic ability of amitriptyline as an intraoral topical anesthetic agent with lidocaine gel. Methods This study was a comparative clinical study between two medications' anesthetic properties. This study included 120 patients indicated for bilateral orthodontics (the subdivision of dentistry that emphasizes identifying necessary interventions for the malocclusion of teeth) procedures. All the subjects were divided into amitriptyline and lidocaine groups. Both anesthetic gels were applied at separate sites before the injection of LA. The time of the onset of anesthesia was noted and analyzed. Patients were selected on the basis of inclusion and exclusion criteria. Individuals aged 18 to 30 years who were systemically healthy and orthodontically indicated for bilateral premolar extraction were included in this study. Again, patients with a history of neurological disorders and allergies to amitriptyline and lidocaine were excluded from the current study. Results Significant differences emerged between groups at five and 10 minutes, with amitriptyline-induced partial numbness (36.7% and 6.7%). At 40 and 45 minutes, both groups showed varied partial and complete numbness, with amitriptyline leading to partial recovery (23.3% and 73.3% complete numbness, 23.3% partial recovery) and lidocaine resulting in partial recovery (81.7%). When comparing the visual analog scale (VAS) scores, both groups exhibited a similar simultaneous effect at 15 minutes. Nonetheless, amitriptyline displayed significantly lower scores at 25 and 35 minutes (p < 0.001) in comparison to lidocaine. Similar observations were made when controlling for pain intensity. Conclusion It was concluded that amitriptyline holds both anesthetic and analgesic properties. Nevertheless, this study was unable to generalize the study findings because of the small sample size and being a single-center study. However, the VAS scores of anesthetic and analgesic pharmacodynamics properties of amitriptyline were statistically significantly lower than lidocaine, particularly at 25 and 35 minutes. Additionally, amitriptyline-induced anesthetic and analgesic pharmacology, especially pharmacokinetics properties, depends on the location and pattern of pain.

show abstract

Section: Discussionmentioning

confidence: 99%

Anesthetic Effect of 2% Amitriptyline Versus 2% Lidocaine: A Comparative Evaluation

Patel¹,

Urolagin²,

Haq³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…In light of this, lessening or eliminating pain is a crucial aspect of burns management, especially with it being proved that pain can negatively affect mental health and quality of life and also induce a delay on wound healing [ 5 , 10 , 11 , 12 ]. In comparison with infiltration anesthesia and placebos, topical anesthesia offers an effective and safe way to improve the management of pain [ 13 ]. In this respect, local anesthetics with prolonged action have been investigated for pain relief in burns, under different formulations, from liposomes and microspheres to micro-needles and solid drug delivery matrices [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Chitosan Porous Membranes as Potential Therapeutic Systems with Analgesic Effect for Burn Care

Enache¹,

Samoilă²,

Cojocaru³

et al. 2022

Membranes

View full text Add to dashboard Cite

Eliminating or at least lessening the pain is a crucial aspect of burns management, as pain can negatively affect mental health and quality of life, and it can also induce a delay on wound healing. In this context, new amphiphilic chitosan 3D porous membranes were developed and investigated as burns therapeutic systems with analgesic effect for delivery of lidocaine as local anesthetic. The highly porous morphology of the membranes and the structural modifications were evidenced by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis and infrared spectroscopy (FTIR). Improved compression mechanical properties, long-term hydrolytic degradation (28 days) evaluation and high swelling capacities (ranging from 8 to 22.6 g/g) indicate an increased capacity of the prepared membranes to absorb physiological fluids (burns exudate). Lidocaine in vitro release efficiency was favored by the decreased content of cross-linking agent (reaching maximum value of 95.24%) and the kinetic data modeling, indicating that lidocaine release occurs by quasi-Fickian diffusion. In addition to the in vitro evaluation of analgesic effect, lidocaine-loaded chitosan membranes were successfully investigated and proved antibacterial activity against most common pathogens in burns infections: Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus.

show abstract

Anesthetic effect of lidocaine injection for maxillary teeth with or without tetracaine gel as topical agent during dental extraction in sensitive patients

H Al-Mukhtar,

Hamid,

H Deleme

2024

Edorium J Dent

View full text Add to dashboard Cite

Aims: Anxiety and fear from dental injections are common and particularly tense features in dental treatment. The direct sense of pain during the injection technique contributes significantly to this dread. The aim of the study was to assess the anesthetic effectiveness and pain of injectable buffered lidocaine with epinephrine with topical tetracaine gel (1%, 1.5%, and 2%) and placebo gel before injection. Methods: A randomized clinical trial was conducted patients attending the integrated clinics of the dentistry at Mosul University who needed dental surgical treatment. A total of 96 adult patients participated in the study, including 51 males and 45 females. Participants were randomly allocated into four groups, 24 for each one. The injection site was dried with gauze and approximately 0.2 mL of topical anesthetic agent with different concentrations utilized, then after 2 minutes’ local anesthesia, lidocaine with adrenaline with needle gauge 27 was applied for maxillary premolars and molars for infiltration technique and using pain scores as a parameter to assess pain and anxiety sensation. Therefore, the study involves 4 groups. Group A 1%, group B 1.5%, group C 2% tetracaine gel, and group D placebo (ultrasonic gel) as the control group, the data collected and analyzed. Results: From 96 participants (53.13% male and 46.87% female), there was a highly statistically significant difference between groups regarding pain sensation at time of injection, especially group C with 2% concentration of tetracaine in comparison with other groups. Conclusion: Topical anesthetics considerably lessened injection and needle insertion pain as compared to the placebo group, also topical anesthesia has a significant psychological impact on patients’ attitudes toward dental treatment, with most patients demanding topical anesthesia before dental injections in order to reduce their level of anxiety and fear toward dental injections.

show abstract

Effectiveness of Topical Anesthetics in Pain Management for Dermal Injuries: A Systematic Review

Cited by 5 publications

References 28 publications

Anesthetic Effect of 2% Amitriptyline Versus 2% Lidocaine: A Comparative Evaluation

Anesthetic Effect of 2% Amitriptyline Versus 2% Lidocaine: A Comparative Evaluation

Amphiphilic Chitosan Porous Membranes as Potential Therapeutic Systems with Analgesic Effect for Burn Care

Anesthetic effect of lidocaine injection for maxillary teeth with or without tetracaine gel as topical agent during dental extraction in sensitive patients

Contact Info

Product

Resources

About