Effectiveness of topical autologous serum treatment in neurotrophic keratopathy

Guadilla, A.M.; Balado, P.; Baeza, A.; Merino, María Luísa García

doi:10.1016/j.oftale.2013.09.017

Cited by 15 publications

(8 citation statements)

References 17 publications

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“…The use of autologous serum eye drops, topical non‐gelified platelet‐rich plasma (PRP), and umbilical cord serum eye drops have been proposed in several open‐label studies that reported a high corneal healing rate in patients with NK (Matsumoto et al, ; Geremicca et al, ; Guadilla et al, ). It has been shown that these agents contain several growth factors, neuromediators, and vitamins that may improve ocular surface healing (Matsumoto et al, ).…”

Section: Role Of Corneal Innervation In the Maintenance Of A Healthy mentioning

confidence: 99%

Understanding the Pathogenesis of Neurotrophic Keratitis: The Role of Corneal Nerves

Mastropasqua

Massaro-Giordano

Nubile

et al. 2016

Journal Cellular Physiology

121

111

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Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by trigeminal nerve damage, which leads to loss of corneal sensitivity, corneal epithelium breakdown, and poor healing. Though extremely uncommon, NK is increasingly recognized for its characteristics as a distinct and well-defined clinical entity rather than a rare complication of various diseases that can disrupt trigeminal innervation. Indeed, the defining feature of NK is loss of corneal sensitivity, and its clinical findings do not correlate with the wide range of systemic or ocular conditions that underlie trigeminal nerve damage. Despite increasing awareness of NK as a distinct condition, its management continues to be challenged by the lack of treatments that target nerve regeneration. This review focuses on the role of corneal nerves in maintaining ocular surface homeostasis, the consequences (such as alterations in neuromediators and corneal cell morphology/function) of impaired innervation, and advances in NK diagnosis and management. Novel therapeutic strategies should aim to improve corneal innervation in order support corneal renewal and healing. J. Cell. Physiol. 232: 717-724, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Role Of Corneal Innervation In the Maintenance Of A Healthy mentioning

confidence: 99%

Understanding the Pathogenesis of Neurotrophic Keratitis: The Role of Corneal Nerves

Mastropasqua

Massaro-Giordano

Nubile

et al. 2016

Journal Cellular Physiology

121

111

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“…This treatment has been around for decades, used to relieve symptoms and promote re-epithelialization in a variety of ocular surface conditions including chemical burns and dry eye disease in patients with Sjögren's syndrome [59,60]. Several retrospective serum tear studies of limited sample size have demonstrated an improvement in epithelial defects in early stages of NK with accompanying visual acuity improvement, and minimal to mild corneal sensation returns measured by CB esthesiometry and modified Belmonte esthesiometer [58,[61][62][63][64]. An observational study of 22 eyes of all stages of NK found favorable changes in the corneal nerves via the in vivo confocal microscopy, healing of the epithelial defect for 91% of patients within 12 weeks, and improvement in BCVA in 71% of patients [63].…”

Section: Serum Tearsmentioning

confidence: 99%

Corneal Neurotization and Novel Medical Therapies for Neurotrophic Keratopathy

Rosenblatt

Sears

Park

et al. 2020

Curr Ophthalmol Rep

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Purpose of Review Neurotrophic keratopathy (NK) is a degenerative corneal disease characterized by decreased corneal sensibility and impaired corneal healing. In this article, we review surgical techniques for corneal neurotization (CN) and novel medical therapies for the treatment of NK. Recent Findings In recent decades, there has been a paradigm shift in the treatment strategies for NK. New minimally invasive direct and indirect CN approaches have demonstrated efficacy at improving best-corrected visual acuity and central corneal sensation while decreasing surgical morbidity. In addition, several targeted medical therapies, such as recombinant human nerve growth factor (rhNGF), regenerating agents (RGTA), and nicergoline, have shown promise in improving corneal epithelial healing. Of these options, cenegermin (Oxervate®, Dompé), a topical biologic medication, has emerged as an approved medical treatment for moderate to severe NK. Summary NK is a challenging condition caused by alterations in corneal nerves, leading to impairment in sensory and trophic function with subsequent breakdown of the cornea. Conventional therapy for NK depends on the severity of disease and focuses primarily on protecting the ocular surface. In recent years, numerous CN techniques and novel medical treatments have been developed that aim to restore proper corneal innervation and promote ocular surface healing. Further studies are needed to better understand the long-term efficacy of these treatment options, their target populations, and the potential synergistic efficacy of combined medical and surgical treatments.

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“…Further therapeutic options for severe NK cases are minimally invasive procedures, e.g., tarsorraphy, induction of ptosis by botulinum toxin A, amniotic membrane transplantation (AMT) or surgical interventions, such as conjunctival flap cover surgery and corneal grafting. 5 , 6 , 7 , 8 , 9 Recent research on NK has been focused on novel medical treatment strategies promoting wound healing and restoring corneal sensitivity and visual acuity. 3…”

Section: Introductionmentioning

confidence: 99%