Effectiveness of traditional Chinese medicine in treating gastrointestinal dysfunction in patients with acute stroke: a systematic review and meta-analysis of 16 randomized controlled trials

Wang, Yanxin; Wang, Luting; Huang, Zhongcheng; Li, Tian-Lun; Ouyang, Xiao-fang

doi:10.21037/apm-21-2915

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Therefore, those with CVA with phlegm-heat-infused lung type often have recurrent cough, especially at night, and are often accompanied by real hot symptoms such as thick sputum, red face and lips, thirst, yellow urine, and constipation [ 19 ]. Based on our years of clinical experience, we combined the etiology and pathogenesis of CVA and established the treatment rules, focusing on clearing the lung and resolving phlegm, lowering qi, relieving cough, and calming asthma, and applied the self-prepared Rational Lung and Asthma Determining Tang to treat the evidence of phlegm and heat in the lung of CVA [ 20 ]. Self-designed Ruling Lung and Asthma Tang is derived from the combination of Self-designed Ruling Lung and Asthma Tang and Self-designed Ruling Lung and Asthma Tang [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Study on the Effect of Self-Made Lifei Dingchuan Decoction Combined with Western Medicine on Cough Variant Asthma

Huang

et al. 2022

Computational and Mathematical Methods in Medicine

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Aims. To observe the clinical efficacy of self-made Lifei Dingchuan decoction combined with western medicine in the treatment of cough variant asthma (phlegm-heat accumulation in the lung syndrome). Materials and Methods. The clinical data of 90 patients with cough variant asthma who were hospitalized in the Department of Respiratory Medicine of our hospital from January 2020 to April 2022 were selected as the research objects, and they were equally divided into the observation group and the reference group according to different treatment methods, 45 cases in each group. The group was treated with traditional montelukast sodium chewable tablet and salmeterol fluticasone mixed powder inhalation, and the observation group was treated with self-made Lifei Dingchuan decoction on the basis of the control group, saturation, pH, partial pressure of oxygen in arterial blood, partial pressure of carbon dioxide, length of stay, and hospitalization costs. Results. After the patients underwent self-made Lifei Dingchuan decoction, there were significant differences between the observation group and the reference group in terms of heart rate, respiratory rate, blood oxygen saturation, pH value, arterial blood oxygen partial pressure, carbon dioxide partial pressure, and within the group. There was a statistical difference ( P < 0.05 ). The adverse reactions in patients with cough variant asthma after treatment showed that the red throat, shortness of breath, chest tightness, and dry mouth in the observation group were significantly different from those in the control group ( P < 0.05 ). After investigation, follow-up, and statistics, the hospitalization time, hospitalization cost, asthma exacerbation control time, effective rate, and recurrence rate were compared between the two groups, and the differences between the two groups were statistically significant ( P < 0.05 ). Conclusion. The study on the clinical efficacy and low hospitalization cost of the self-prepared lung and asthma-restorative soup in patients with cough variant asthma significantly improved the patients’ arterial oxygen saturation, acid-base value, arterial partial pressure of oxygen, and partial pressure of carbon dioxide and effectively controlled the heart rate and respiratory rate with high safety, which is worth further promotion.

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Section: Discussionmentioning

confidence: 99%

Study on the Effect of Self-Made Lifei Dingchuan Decoction Combined with Western Medicine on Cough Variant Asthma

Huang

et al. 2022

Computational and Mathematical Methods in Medicine

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Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis

Zhai¹,

Su²,

Ma³

et al. 2023

Biomedicine & Pharmacotherapy

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Interventional strategies for ischemic stroke based on the modulation of the gut microbiota

Wang

Liu

2023

Front. Neurosci.

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The microbiota-gut-brain axis connects the brain and the gut in a bidirectional manner. The organism’s homeostasis is disrupted during an ischemic stroke (IS). Cerebral ischemia affects the intestinal flora and microbiota metabolites. Microbiome dysbiosis, on the other hand, exacerbates the severity of IS outcomes by inducing systemic inflammation. Some studies have recently provided novel insights into the pathogenesis, efficacy, prognosis, and treatment-related adverse events of the gut microbiome in IS. In this review, we discussed the view that the gut microbiome is of clinical value in personalized therapeutic regimens for IS. Based on recent non-clinical and clinical studies on stroke, we discussed new therapeutic strategies that might be developed by modulating gut bacterial flora. These strategies include dietary intervention, fecal microbiota transplantation, probiotics, antibiotics, traditional Chinese medication, and gut-derived stem cell transplantation. Although the gut microbiota-targeted intervention is optimistic, some issues need to be addressed before clinical translation. These issues include a deeper understanding of the potential underlying mechanisms, conducting larger longitudinal cohort studies on the gut microbiome and host responses with multiple layers of data, developing standardized protocols for conducting and reporting clinical analyses, and performing a clinical assessment of multiple large-scale IS cohorts. In this review, we presented certain opportunities and challenges that might be considered for developing effective strategies by manipulating the gut microbiome to improve the treatment and prevention of ischemic stroke.

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Effectiveness of traditional Chinese medicine in treating gastrointestinal dysfunction in patients with acute stroke: a systematic review and meta-analysis of 16 randomized controlled trials

Cited by 3 publications

References 8 publications

Study on the Effect of Self-Made Lifei Dingchuan Decoction Combined with Western Medicine on Cough Variant Asthma

Study on the Effect of Self-Made Lifei Dingchuan Decoction Combined with Western Medicine on Cough Variant Asthma

Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis

Interventional strategies for ischemic stroke based on the modulation of the gut microbiota

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