Effectiveness of transbronchial needle aspiration in the diagnosis of exophytic endobronchial lesions and submucosal/peribronchial diseases of the lung

Kacar, Nazan; Tuksavul, Fevziye; Edipoglu, Ozlem; Ermete, Sülün; Güçlü, Salih Zeki

doi:10.1016/j.lungcan.2005.05.018

Cited by 33 publications

(39 citation statements)

References 19 publications

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“…The diagnostic rate for cryobiopsy is the highest rate observed for any single sampling technique in bronchoscopy [7][8][9]. Even where multiple sampling techniques (forceps, needles, brushing and washing) are utilised, the diagnostic yield reaches only 88% [2,8,10,11]. The difference in our results is unlikely to be due to a poor yield in the standard forceps group, as its diagnostic rate is similar to other published studies [7][8][9]10].…”

Section: Discussionsupporting

confidence: 76%

Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial

Hetzel¹,

Eberhardt²,

Herth³

et al. 2011

Eur Respir J

237

182

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Forceps, brushes or needles are currently the standard tools used during flexible bronchoscopy when diagnosing endobronchial malignancies. The new biopsy technique of cryobiopsy appears to provide better diagnostic samples. The aim of this study was to evaluate cryobiopsy over conventional endobronchial sampling.A total of 600 patients in eight centres with suspected endobronchial tumours were included in a prospective, randomised, single-blinded multicentre study. Patients were randomised to either sampling using forceps or the cryoprobe. After obtaining biopsy samples, a blinded histological evaluation was performed. According to the definitive clinical diagnosis, the diagnostic yield for malignancy was evaluated by a Chi-squared test.A total of 593 patients were randomised, of whom 563 had a final diagnosis of cancer. 281 patients were randomised to receive endobronchial biopsies using forceps and 282 had biopsies performed using a flexible cryoprobe. A definitive diagnosis was achieved in 85.1% of patients randomised to conventional forceps biopsy and 95.0% of patients who underwent cryobiopsy (p,0.001). Importantly, there was no difference in the incidence of significant bleeding.Endobronchial cryobiopsy is a safe technique with superior diagnostic yield in comparison with conventional forceps biopsy.

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Section: Discussionsupporting

confidence: 76%

Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial

Hetzel¹,

Eberhardt²,

Herth³

et al. 2011

Eur Respir J

237

182

View full text Add to dashboard Cite

show abstract

“…Therefore, besides conventional transbronchial needle aspiration (TBNA), endobronchial ultrasound and endoesophageal ultrasound, and especially the combination of both, are increasingly used worldwide as the primary diagnostic methods [18,19,20,21]. However, this also means that most of the available material is shifted from being histological to cytological.…”

Section: Aspects Of Tumor Samplingmentioning

confidence: 99%

Preparation of Cell Blocks for Lung Cancer Diagnosis and Prediction: Protocol and Experience of a High-Volume Center

et al. 2014

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Minimally invasive diagnostic techniques are increasingly being used to obtain specimens for pathological diagnosis and prediction. Referring to lung cancer, both endobronchial and endoesophageal ultrasound are used worldwide as diagnostic routine methods. Consequently, an increasing number of pathological samples are cytological and fewer are histological. On the other hand, the requirements for specific and sensitive tumor subtyping complemented by predictive analyses are steadily increasing and are an essential basis for evidence-based treatment decisions. In this article we focus on the cell block method as a helpful tool for diagnostic and predictive analyses in lung cancer and point out its advantages and disadvantages in comparison to conventional cytological and biopsy specimens. Furthermore, we retrospectively analyze the diagnostic results of the cell block method in a high-volume center over 5 years. The main advantages of cell blocks are the availability of established and validated protocols, archiving and the opportunity to have serial sections from the same specimens to provide or repeat molecular analyses. Actually, in case of tumor progression, even additional biomarkers can be tested using the original cell block when re-biopsies are not feasible. The cell block method should be considered as a reliable, complimentary approach to conventional cytological or biopsy procedures, which is helpful to fulfill the increasing requirements of high-quality diagnostics and prediction.

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“…TBNA is a safe and useful method for diagnosis and is considered a valuable diagnostic tool together with conventional diagnostic procedures like forceps biopsy and brushing [20]. It is often used as an alternative technique for endobronchial tumors displaying a tendency to bleed, covered by necrosis, or unable to be diagnosed by forceps biopsy of a crush artifact [21].…”

Section: Discussionmentioning

confidence: 99%

Liquid-Based Thin-Layer Cytology Can Be Routinely Used in Samples Obtained via Fiberoptic Bronchoscope

Kobayashi¹,

Uehara²,

Ota

2010

Acta Cytologica

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Objective: The aim of this study was to evaluate liquid-based preparations (LBP) as a replacement for conventional smears (CS) of bronchial brushing (BB) and transbronchial fine-needle aspiration (TBNA) samples obtained via fiberoptic bronchoscope. Study Design: Bronchial brushing and TBNA samples were obtained from 62 and 33 patients by fiberoptic bronchoscopy, respectively. Liquid-based preparations were prepared from needle rinse after initial CS preparation. We compared cellularity, cell morphology, and background between the LBP and CS slides. Results: Correspondence rates between LBP and CS diagnoses in the above 3 categories were 90.3% in the BB and 97.0% in the TBNA samples. If suspicious cases were regarded as malignant, correspondence rates reached 98.4 and 100%, respectively. Histological diagnoses by LBP were mostly the same as those by CS and by biopsy or operation samples. Morphologically, cells and nuclei were shrunk in the LBP; however, the shrinking was not severe enough to influence cytological diagnoses. Blood background and air-drying, which were observed on many of the CS slides, were not detected on the LBP slides. Conclusion: It is possible to use LBP for routine laboratory processing of BB and TBNA samples as a replacement for CS.

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Effectiveness of transbronchial needle aspiration in the diagnosis of exophytic endobronchial lesions and submucosal/peribronchial diseases of the lung

Cited by 33 publications

References 19 publications

Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial

Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial

Preparation of Cell Blocks for Lung Cancer Diagnosis and Prediction: Protocol and Experience of a High-Volume Center

Liquid-Based Thin-Layer Cytology Can Be Routinely Used in Samples Obtained via Fiberoptic Bronchoscope

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