2022
DOI: 10.1136/bmjopen-2022-066945
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Effectiveness of two doses of Euvichol-plus oral cholera vaccine in response to the 2017/2018 outbreak: a matched case–control study in Lusaka, Zambia

Abstract: IntroductionZambia experienced a major cholera outbreak in 2017–2018, with more than 5905 cases reported countrywide, predominantly from the peri-urban slums of Lusaka city. The WHO recommends the use of oral cholera vaccines (OCVs) together with traditional control measures, including health promotion, provision of safe water and improving sanitation, in cholera endemic areas and during cholera outbreaks. In response to this outbreak, the Zambian government implemented the OVC campaign and administered the Eu… Show more

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Cited by 16 publications
(16 citation statements)
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“… 6 Almost all evidence of kOCV clinical protection is based on the studies carried out on Shanchol, 7 , 8 , 9 although one observational study explored the protection conferred by a Euvichol-Plus two-dose regimen. 10 …”
Section: Introductionmentioning
confidence: 99%
“… 6 Almost all evidence of kOCV clinical protection is based on the studies carried out on Shanchol, 7 , 8 , 9 although one observational study explored the protection conferred by a Euvichol-Plus two-dose regimen. 10 …”
Section: Introductionmentioning
confidence: 99%
“…The study sites included the four subdistricts of Lusaka (Kanyama, Chawama, Chipata and Matero) where the 2018 OCV campaign was conducted. The combined population for the four subdistricts was 1543 507 (see our previous work on the 2018 Lusaka cholera outbreak and for the details on the study setting) 21–23. The study population included all individuals older than 12 months residing in the study sites.…”
Section: Methodsmentioning
confidence: 99%
“…An oral cholera vaccine has been introduced and rolled out widely to prevent the spread of ongoing epidemics to unaffected areas and prevent epidemics in humanitarian settings. [17][18][19] As a renewed effort to curb the scourge of the disease, the Global Taskforce on Cholera Control developed a global strategy for cholera control in 2017, with a 2030 target for a 90% reduction in cases and deaths, and elimination in 20 countries, and is currently supporting countries including those of Africa to implement the strategy. 20 Several Africanled initiatives to scale up the prevention and control of the disease have been implemented with some success.…”
Section: Introductionmentioning
confidence: 99%