Background: Research indicates that certain demographic groups, including girls, often experience lower-than-average levels of mental well-being. Therefore, it appears that one approach to enhancing mental health is by teaching resilience skills. Objectives: This study aimed to investigate the effects of resilience training on the mental health dimensions of sixth-grade female students in Qaynat city during the academic year 2021 - 2022. Methods: The study employed an experimental design with a control group, conducting pre- and post-tests. The statistical population comprised female sixth-grade students from an elementary school in Qaynat City. Thirty female students exhibiting high scores on measures of depression, anxiety, and stress were selected and randomly divided into two experimental groups, with 15 participants in each group. The experimental group underwent resilience training consisting of 8 sessions. The desired variables were measured using Lovibond and Lovibond's Depression, Anxiety, and Stress Scale (DASS). The data were analyzed using SPSS 25 software through independent samples t-tests and paired t-tests. Results: The findings revealed that the resilience training intervention significantly reduced symptoms of depression (F = 11.542), anxiety (F = 13.67), and stress (F = 6.01) in the experimental group (P = 0.001). Conclusions: The results suggest that participation in a resilience training program can improve students' mental health. Therefore, implementing such intervention programs in the form of workshops and establishing counseling and support groups may be beneficial for enhancing students' mental well-being.