Effectiveness of Vitamin B₁₂in Combined System Disease

Effect of Vitamin B12 on Neuropathy in Pernicious Anaemia Treated with Folic Acid

“…Our observations confirmed the experiences of Berk et al (1948), Hall and Campbell (1948), Hall et al (1949, Mollin (1949), andUngley (1949), who found vitamin B12 effective in the treatment of neurological complications of pernicious anaemia. Summary A case of severe psychoneuropathy in the course of folicacid treatment of pernicious anaemia is reported.…”

Vitamin B12 in Pernicious Anaemia

“…Our findings amplify earlier reports on the effect of vitamin B12 given parenterally in pernicious anaemia (West, 1948;Ungley, 1948aUngley, , 1948bUngley, , 1949Hall and Campbell, 1948;Spies, Stone, Kartus, and Aramburu, 1948;Berk, Denny-Brown, Finland, and Castle, 1948;Bethell, Meyers, and Neligh, 1948 ;Spies, Suarez, Garcia Lopez, Milanes, Stone, Lopez Toca, Aramburu, and Kartus, 1949;West and Reisner, 1949 160 ,ug. Conclusions are based on the means of a number of responses at each dose level. Reticulocyte responses were compared with the "expected " response to liver extract according to Isaacs and Friedman (1938), but a better yardstick was the increase of red blood cells in 15 days.…”

Vitamin B12 in Megaloblastic Anaemia of Pregnancy and Tropical Nutritional Macrocytic Anaemia

“…-Weiden, S., and Moore, A. (1949 The value of vitamin B2 in Addisonian pernicious anaemia, subacute combined degeneration, nutritional macrocytic anaemia, and tropical macrocytic anaemia has been thoroughly acknowledged (West, 1948;Berk et al, 1948, ;Ungley, 1948a;Campbell, 1948a, 1948b;Spies et al, 1948aSpies et al, , 1948b1949;Patel, 1948Patel, , 1950Das Gupta, 1950). Reports of its use in megaloblastic (" pernicious ") anaemia of pregnancy, however, are contradictory.…”