Effectiveness of Weekly Teriparatide Injection in Postmenopausal Patients with Hip Fractures

Lee, Sang Yeob; Seo, Min-Seok; Yoo, Jun‐Il

doi:10.4055/cios22280

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Fractures are also directly related with increased social expenses, as they can result in extended absences, substantial use of medical resources, and long-term impairment 2 . Age, gender, menopause, underweight, obesity, smoking, excessive alcohol use, and lack of physical activity are well-known risk factors associated with an increase in fractures [3][4][5][6][7][8][9][10][11] . Weight loss has been linked to osteoporosis and sarcopenia, and weight gain has been demonstrated to help maintain bone density 12,13 .…”

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confidence: 99%

Underweight and risk of fractures in adults over 40 years using the nationwide claims database

Park

Han

et al. 2023

Sci Rep

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We aimed to investigate how underweight affects the incidence of fractures, as well as the influence of cumulative, longitudinal periods of low body mass index (BMI) and changes in body weight on fracture development. Data on adults aged 40-year and over who had three health screenings between January 1, 2007, and December 31, 2009 were used to determine the incidence of new fractures. The hazard ratios (HRs) for new fractures depending on BMI, total cumulative number of underweight, and weight change over time were calculated using Cox proportional hazard analysis. In this study, 15,955 (2.8%) of the 561,779 adults were diagnosed with fractures more than once over three health examinations. The fully adjusted HR for fractures in underweight individuals was 1.173 (95% Confidence interval [CI] 1.093–1.259). Underweight individuals diagnosed only once, twice, or three times had an adjusted HR of 1.227 (95%CI 1.130–1.332), 1.174 (95%CI 1.045–1.319), and 1.255 (95%CI 1.143–1.379), respectively. Although the adjusted HR was higher in adults who consistently had underweight (HR; 1.250 [95%CI 1.146–1.363]), those with underweight had an increased risk of fractures regardless of weight change (HR; 1.171 [95%CI 1.045–1.312], and 1.203[95%CI 1.075–1.346]). Underweight is a risk factor for fractures in adults over the age of 40 years, even if they returned to normal weight.

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confidence: 99%

Underweight and risk of fractures in adults over 40 years using the nationwide claims database

Park

Han

et al. 2023

Sci Rep

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Risk of fracture according to temporal changes of low body weight changes in adults over 40 years: a nationwide population-based cohort study

et al. 2023

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Background Low body weight is associated with an increased risk of fractures. However, the effect of temporal changes in the low body weight status on the risk of fracture remains unknown. This study aimed to evaluate the relationships between temporal changes in low body weight status and the risk of fractures in adults over the age of 40 years. Methods This study included data on adults over 40 years old who underwent two biannual consecutive general health examinations between January 1, 2007 and December 31, 2009 extracted from the National Health Insurance Database, a large nationwide population database. Fracture cases in this cohort were monitored from the time of the last health examination to the end of the designated follow-up period (from January 1, 2010 to December 31, 2018) or the participant's death. Fractures were defined as any fracture resulting in hospitalization or outpatient treatment claim after the date of general health screening. The study population was then separated into four groups based on the temporal changes in low body weight status as follows: low body weight to low body weight (L-to-L), low body weight to non-low body weight (L-to-N), non-low body weight to low body weight (N-to-L), and non-low body weight to non-low body weight (N-to-N). The hazard ratios (HRs) for new fractures, depending on weight changes over time, were calculated using Cox proportional hazard analysis. Results Adults in the L-to-L, N-to-L, and L-to-N groups had a substantially increased risk of fractures after multivariate adjustment (HR, 1.165; 95% confidence interval [CI], 1.113–1.218; HR, 1.193; 95% CI, 1.131–1.259; and HR, 1.114; 95% CI, 1.050–1.183, respectively). Although the adjusted HR was greater in participants who changed into having a low body weight, followed by those with consistently low body weight, those with low body weight remained to have an elevated risk of fracture independent of weight fluctuation. Elderly men (aged over 65 years), high blood pressure, and chronic kidney disease were significantly associated with an increase in fractures (p < 0.05). Conclusion Individuals aged over 40 years with low body weight, even after regaining normal weight, had an increased risk of fracture. Moreover, having a low body weight after having a normal body weight increased the risk of fractures the most, followed by those with consistently low body weight.

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Association between the use of proton pump inhibitors and osteoporosis/fracture: nested case-control studies using a national health screening cohort

Youk,

Lee,

Lee

et al. 2024

Preprint

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Proton pump inhibitors (PPIs) are widely used to treat acid-related disorders. However, PPI use may be associated with an increased risk of osteoporosis and fractures. Therefore, this study aimed to investigate the association between PPI use and the risk of osteoporosis and fractures using national data. Two nested case-control studies were conducted using nationwide population cohort data. The first study included patients with osteoporosis and controls while the second included patients with fractures and controls. Associations between PPI use and the risk of osteoporosis and fractures were analyzed using propensity score overlap-weighted odds ratios (ORs). The results showed that current PPI use was associated with a higher risk of osteoporosis than non-use (overlap-weighted OR = 37.4, 95% confidence interval: 33.3–42.1, P < 0.001). This association was stronger with a longer duration of PPI use. Similar associations were observed for distal radius, hip, and spinal fractures in the patient group. However, no significant associations were observed between PPI use and fractures in the PPI-treated group. Here, PPI use was associated with a higher risk of osteoporosis and fractures, particularly with a longer duration of use. Therefore, clinicians should consider the potential risks associated with PPIs when prescribing them to patients with acid-related disorders.

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Effectiveness of Weekly Teriparatide Injection in Postmenopausal Patients with Hip Fractures

Cited by 4 publications

References 28 publications

Underweight and risk of fractures in adults over 40 years using the nationwide claims database

Underweight and risk of fractures in adults over 40 years using the nationwide claims database

Risk of fracture according to temporal changes of low body weight changes in adults over 40 years: a nationwide population-based cohort study

Association between the use of proton pump inhibitors and osteoporosis/fracture: nested case-control studies using a national health screening cohort

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