Effectiveness of zebrafish models in understanding human diseases—A review of models

Adhish, Mazumder; Manjubala, I.

doi:10.1016/j.heliyon.2023.e14557

Cited by 59 publications

(23 citation statements)

References 123 publications

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“…The study of various behavioural models has shown that coping style determines, to a large degree, the reaction of the neuroendocrine system to stress, therefore influencing several aspects of the stress response such as activation of the sympathetic nervous system (SNS) and hypothalamic-pituitary-interrenal/adrenal (HPI/HPA) axis, both systems affecting the immune system ( Wilson et al, 2019 ). In this context, zebrafish has emerged as a promising model for the study of behaviour and personality due to high genetic and physiological homology with humans along with two well-defined personality patterns (proactive/bold and reactive/shy) and the same modulatory neurotransmitters found in the mammalian brain (e.g., serotonergic, and dopaminergic systems) ( Adhish and Manjubala, 2023 ; Xie et al, 2022 ; Gould et al, 2021 ). Therefore, assessing the effects of SSRIs on zebrafish personality may be very helpful in understanding the potential effects of these antidepressants on human personality, which is clinically and environmentally relevant.…”

Section: Translational Research: Fish As a Proxy For Individual Disea...mentioning

confidence: 99%

“…This can be studied in organisms like zebrafish ( Danio rerio ) that display two well-defined and distinct personality patterns. An additional advantage of using this species is its high genetic homology and significant conservation of monoaminergic systems with humans ( Adhish and Manjubala, 2023 ; Xie et al, 2022 ; Gould et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Identifying knowledge gaps in understanding the effects of selective serotonin reuptake inhibitors (SSRIs) on fish behaviour

et al. 2023

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Section: Translational Research: Fish As a Proxy For Individual Disea...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identifying knowledge gaps in understanding the effects of selective serotonin reuptake inhibitors (SSRIs) on fish behaviour

et al. 2023

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“…This model is excellent for extrapolating results to humans, owing to its high genetic compatibility. Seventy percent of the genes that code for proteins in humans are related to genes found in zebrafish, and 84% of the genes associated with human diseases have homologs in this animal [ 15 ]. Humans and wildlife share common environments and food chains, and the physiological and molecular pathways altered in response to toxic chemicals are often highly conserved among vertebrates [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Ecotoxicological Effects of TiO2 P25 Nanoparticles Aqueous Suspensions on Zebrafish (Danio rerio) Eleutheroembryos

Ortiz-Román,

Casiano-Muñiz,

Román-Velázquez

2024

Nanomaterials

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Among nanoparticles (NPs), titanium dioxide is one of the most highly manufactured worldwide and widely used in multiple products for both industrial use and personal care products. This increases the probability of release into aquatic environments, potentially affecting these ecosystems. The present study aimed to evaluate TiO2 P25 NP toxicity in zebrafish embryos and eleutheroembryos by evaluating LC50, hatching rate, embryo development, and chemical analysis of the TiO2 concentration accumulated in eleutheroembryo tissues. Zebrafish embryos ~2 h post-fertilization (hpf) were exposed to 75, 100, 150, 200, and 250 mg/L TiO2 P25 NPs for 48 and 96 h. A total of 40–60 embryos were placed in each Petri dish for the respective treatments. Three replicates were used for each treatment group. Ti4+ concentrations were determined by inductively coupled plasma optical emission spectrometry (ICP-OES), and a conversion factor was used to calculate the TiO2 concentrations in the tissues. The highest calculated concentrations of TiO2 in zebrafish larvae were 1.0199 mg/L after 48 h and 1.2679 mg/L after 96 h of exposure. The toxicological results indicated that these NPs did not have a significant effect on the mortality and hatching of zebrafish embryos but did have an effect on their development. LC20 and LC30 were determined experimentally, and LC50 and LC80 were estimated using four different methods. Up to 11% of embryos also presented physical malformations. These effects can be detrimental to a species and affect ecosystems. Physical malformations were observed in all treatments, indicating teratogenic effects.

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“…These include its small size, ability to produce a large number of eggs, external fertilization, fast development, transparent embryos for easy observation, and easy maintenance in laboratory settings [ 13 , 14 ]. It is worth mentioning that zebrafish and humans share many similarities since both are vertebrates [ 15 ]. The sequencing of the zebrafish genome was completed in 2009, and it was found that it has 87% similarity to the human genome.…”

Section: Introductionmentioning

confidence: 99%

Developmental Toxicity of PEDOT:PSS in Zebrafish: Effects on Morphology, Cardiac Function, and Intestinal Health

Yang,

Gou,

et al. 2024

Toxics

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Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a conductive polymer commonly used in various technological applications. However, its impact on aquatic ecosystems remains largely unexplored. In this study, we investigated the toxicity effects of PEDOT:PSS on zebrafish. We first determined the lethal concentration (LC50) of PEDOT:PSS in zebrafish and then exposed AB-type zebrafish embryos to different concentrations of PEDOT:PSS for 120 h. Our investigation elucidated the toxicity effects of zebrafish development, including morphological assessments, heart rate measurements, behavioral analysis, transcriptome profiling, and histopathological analysis. We discovered that PEDOT:PSS exhibited detrimental effects on the early developmental stages of zebrafish, exacerbating the oxidative stress level, suppressing zebrafish activity, impairing cardiac development, and causing intestinal cell damage. This study adds a new dimension to the developmental toxicity of PEDOT:PSS in zebrafish. Our findings contribute to our understanding of the ecological repercussions of PEDOT:PSS and highlight the importance of responsible development and application of novel materials in our rapidly evolving technological landscape.

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Effectiveness of zebrafish models in understanding human diseases—A review of models

Cited by 59 publications

References 123 publications

Identifying knowledge gaps in understanding the effects of selective serotonin reuptake inhibitors (SSRIs) on fish behaviour

Identifying knowledge gaps in understanding the effects of selective serotonin reuptake inhibitors (SSRIs) on fish behaviour

Ecotoxicological Effects of TiO2 P25 Nanoparticles Aqueous Suspensions on Zebrafish (Danio rerio) Eleutheroembryos

Developmental Toxicity of PEDOT:PSS in Zebrafish: Effects on Morphology, Cardiac Function, and Intestinal Health

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