Effectiveness, Safety, and Health-Related Quality of Life of Chronic Migraine Patients Treated with Onabotulinum Toxin A

Abstract

The present study aims to describe the efficacy and safety of onabotulinum toxin A (BonT-A) with evaluation of treatment satisfaction and impact on quality of life in chronic migraine (CM) patients in real life. Methods: This study was conducted in CM patients who were treated with BoNT-A with 12 months of follow-up. Data about outcome, adverse events, and patients' pre-and post-treatment status including health-related quality of life data were analyzed. Health-related quality of life scores were measured at baseline and months 6 and 12 after the beginning of BoNT-A administration. Results: Of 42 enrolled patients, 30 were included in the analysis. At 12 months, all patients showed a reduction in number of headaches and analgesic use per month and none reported adverse events. After BoNT-A supplementation, health-related quality-of-life scores improved significantly. There was a direct association between healthrelated quality of life with reduction of headache days at the end of study. Conclusion: This study confirms that BoNT-A treatment is effective on CM and improves the functional well-being and quality of life of patients.

OnabotulinumtoxinA Treatment in Chronic Migraine: Investigation of Its Effects on Disability, Headache and Neck Pain Intensity

“…Results of a population-based study indicated that pain intensity, disability and headache frequency were correlated with quality of life scores ( p < 0.001) [ 61 ]. Beckman et al reported that decreased headache days after ONA treatment were correlated with increased quality of life in chronic migraine patients [ 39 ]. It seems that the decrease in the intensity of headache and neck pain, migraine and neck disability, and the number of days with headaches may increase the quality of life of the patients.…”

“…The disability and pain experienced can affect daily work, family and social life, causing patients to try to find solutions to their problems [ 29 ]. The literature studies have shown reductions in migraine-related pain intensity and monthly migraine headache days and improvements in disability and quality of life outcomes with ONA treatment [ 37 , 38 , 39 ]. However, it is seen that there are no results after ONA treatment related to neck pain and disability in patients with CM and NP.…”