Effectiveness, Tolerability, and Safety of Ectoine-Containing Mouthwash Versus Those of a Calcium Phosphate Mouthwash for the Treatment of Chemotherapy-Induced Oral Mucositis: A Prospective, Active-Controlled, Non-interventional Study

Dao, Van Anh; Bilstein, Andreas; Overhagen, Sabrina; Gergely, Lajos; Baráth, Zoltán; Mösges, Ralph

doi:10.1007/s40487-018-0060-z

Cited by 19 publications

(14 citation statements)

References 36 publications

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“…† Furthermore, in the cytoplasm of living cells, the stabilisation of biomolecules, the type of radiation damage, repair efficiency and biological relevance of a lesion depend on a multitude of factors. This is especially relevant in medical or cosmetic applications 17,[24][25][26] and when an uptake of ectoine by mammalian cells takes place, which was reported for human keratinocytes. 18 On the other hand, Beblo-Vranesevic et al 28 found a decrease in the cellular survival rate in two different microorganisms (H. marinus and A. fulgidus) upon irradiation with UV-C (254 nm) and the external addition of ectoine (0.5 mol L À1 ).…”

Section: Paper Pccpmentioning

confidence: 99%

“…Due to its versatile properties, ectoine is currently used in a multitude of biotechnological, cosmetic and medical applications. 2,3,[22][23][24][25] Most prominently, it is used in sunscreens, despite evidence from recent studies concerning its influence on UV irradiation of biological targets, showing Janus-faced behaviour. 17,20,[26][27][28] Bünger et al irradiated human keratinocytes with UV-A (340-400 nm).…”

Section: Introductionmentioning

confidence: 99%

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Ectoine interaction with DNA: influence on ultraviolet radiation damage

Hahn

Smales

Seitz

et al. 2020

Phys. Chem. Chem. Phys.

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Section: Paper Pccpmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ectoine interaction with DNA: influence on ultraviolet radiation damage

Hahn

Smales

Seitz

et al. 2020

Phys. Chem. Chem. Phys.

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“…Promising findings from clinical trials were reviewed by Casale and colleagues [ 23 ] who attributed topical applied ectoine effectiveness in upper airway inflammations such as acute pharyngitis/laryngitis [ 24 , 25 ], rhinosinusitis, rhinitis sicca, and acute bronchitis [ 26 ]. In addition, several trials showed efficacy of ectoine in various diseases with barrier dysfunctions such as rhinitis sicca [ 27 ], chemotherapy-induced mucositis [ 28 ], lung inflammation caused by environmental pollutants [ 29 ], prevention of upper respiratory infections [ 30 ], and atopic dermatitis [ 31 ]. Moreover, studies on allergic rhinoconjunctivitis [ 27 , 32 , 33 ] and dry eye syndrome [ 34 , 35 ] have been published.…”

Section: Introductionmentioning

confidence: 99%

Ectoine in the Treatment of Irritations and Inflammations of the Eye Surface

Bilstein¹,

Heinrich

Rybachuk

et al. 2021

BioMed Research International

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The ocular surface is facing various unspecific stress factors resulting in irritation and inflammation of the epithelia, causing discomfort to the patients. Ectoine is a bacteria-derived extremolyte with the ability to protect proteins and biological membranes from damage caused by extreme environmental conditions like heat, UV-light, high osmolarity, or dryness. Evidence from preclinical and clinical studies attest its effectiveness in treating several epithelium-associated inflammatory diseases, including the eye surface. In this review, we analysed 16 recent clinical trials investigating ectoine eye drops in patients with allergic conjunctivitis or with other unspecific ocular inflammations caused by e.g. ophthalmic surgery. Findings from these studies were reviewed in context with other published work on ectoine. In summary, patients with irritations and unspecific inflammations of the ocular surface have been treated successfully with ectoine-containing eye drops. In these patients, significant improvement was observed in ocular symptoms of allergic rhinoconjunctivitis, postoperative secondary dry eye syndrome, or ocular reepithelisation after surgery. Using ectoine as an add-on therapy to antihistamines, in allergy patients accelerated symptom relief by days, and its use as an add-on to antibiotics resulted in faster wound closure. Ectoine is a natural substance with an excellent tolerability and safety profile thus representing a helpful alternative for patients with inflammatory irritation of the ocular surface, who wish to avoid local reactions and side effects associated with pharmacological therapies or wish to increase the efficacy of standard treatment regimen.

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“…In the last decade, the bacteria-derived extremolyte ectoine has attracted considerable medical interest. Evidence for the inflammatory-reducing effect of ectoine from preclinical studies [ 9 – 15 ] has heralded its application in the treatment of dermatitis, allergic rhinitis, sinusitis, mucositis, and lung inflammation [ 16 – 22 ]. Ectoine acts via a mechanism shared among extremolytes known as “preferential exclusion” [ 23 ], which means that it is preferentially excluded from the water–protein interface.…”

Section: Introductionmentioning

confidence: 99%

Ectoine lozenges in the treatment of acute viral pharyngitis: a prospective, active-controlled clinical study

Dao¹,

Overhagen

Bilstein

et al. 2019

Eur Arch Otorhinolaryngol

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PurposeAcute pharyngitis is an uncomfortable disorder mostly caused by viruses and for which antibiotics are unwarranted. This study compared lozenges containing ectoine, a natural extremolyte, with hyaluronic acid lozenges and hypertonic saline gargle for symptomatic treatment of acute viral pharyngitis.MethodsThis prospective, controlled clinical study, recruited 90 patients with moderate-to-severe pharyngitis symptoms who chose to use either ectoine (n = 35), hyaluronic acid (n = 35), or saline gargle (n = 20). Patients applied their 7-day treatment from the inclusion visit (V1) until the end-of-study visit (V2). Patients’ pharyngitis symptoms, general health, general treatment effectiveness and tolerability, and patient compliance were assessed by investigators and patients.ResultsThe sum score for three primary symptoms (pain on swallowing, urge to cough, and hoarseness) decreased by 79.5% (ectoine), 72.2% (hyaluronic acid), and 44.8% (saline gargle). Both lozenges were significantly superior to saline gargle (P < 0.05). Regarding general health improvement, ectoine was significantly superior to saline gargle (72.5% vs. 45.2%, P < 0.05), but hyaluronic acid (63.3%) was not. At V2, 65.7% of patients receiving ectoine reported “very good” general health vs. 48.6% of those receiving hyaluronic acid and 20.0% using saline gargle. Ectoine was significantly superior (P < 0.05) to both hyaluronic acid and saline gargle in terms of tolerability and patient compliance. No patients taking ectoine reported unpleasant sensations while applying their treatment, whereas almost half of patients using hyaluronic acid lozenges and saline gargle did.ConclusionTreatment with ectoine lozenges significantly relieves moderate-to-severe symptoms of acute viral pharyngitis and is more effective and tolerable than treatments with hyaluronic acid lozenges and hypertonic saline gargle.Electronic supplementary materialThe online version of this article (10.1007/s00405-019-05324-9) contains supplementary material, which is available to authorized users.

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Effectiveness, Tolerability, and Safety of Ectoine-Containing Mouthwash Versus Those of a Calcium Phosphate Mouthwash for the Treatment of Chemotherapy-Induced Oral Mucositis: A Prospective, Active-Controlled, Non-interventional Study

Abstract: Introduction: Oral mucositis is a frequent complication of cancer chemotherapy and radiotherapy. Ectoine is a natural extremolyte that can stabilize biological membranes and

Cited by 19 publications

References 36 publications

Ectoine interaction with DNA: influence on ultraviolet radiation damage

Ectoine interaction with DNA: influence on ultraviolet radiation damage

Ectoine in the Treatment of Irritations and Inflammations of the Eye Surface

Ectoine lozenges in the treatment of acute viral pharyngitis: a prospective, active-controlled clinical study

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