2019
DOI: 10.14710/jbtr.v5i2.4802
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Effectivity Of Annona Muricata and Artemisinin Combined Therapy on Brain CXCL10 expression (Study in Swiss Mice During Severe Plasmodium Berghei ANKA Infection)

Abstract: Background: Malaria, caused by Plasmodium sp infection, is a major global cause of morbidity and mortality. Most experimental cerebral malaria (ECM) studies show increase number of Th1 cells and CTLs in the brain, due to increase chemokine expression, including CXCL10, a potent chemokine involved in cerebral malaria (CM). Recent studies show that CXCL10 provokes apoptosis of human brain micro-endothelial cells and in vitro neuroglia cells.Objective: To determine whether combination of Annona muricata-leaf-extr… Show more

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“…This synergistic AME-ACT therapy emerges as a superior intervention strategy compared to AME alone. 15 Moreover, the absence of CXCL10 is linked to the accumulation of CXCR3+ CD4+ T-follicular helper cells in the spleen, which are crucial for antibody production, thereby aiding in the control of PbA infection. 16 CXCL10 neutralization or the use of CXCL10 knockout mice has been shown to mitigate brain microvascular inflammation, enhance parasite control, and confer protection against experimental cerebral malaria (ECM) during PbA infection.…”
Section: Introductionmentioning
confidence: 99%
“…This synergistic AME-ACT therapy emerges as a superior intervention strategy compared to AME alone. 15 Moreover, the absence of CXCL10 is linked to the accumulation of CXCR3+ CD4+ T-follicular helper cells in the spleen, which are crucial for antibody production, thereby aiding in the control of PbA infection. 16 CXCL10 neutralization or the use of CXCL10 knockout mice has been shown to mitigate brain microvascular inflammation, enhance parasite control, and confer protection against experimental cerebral malaria (ECM) during PbA infection.…”
Section: Introductionmentioning
confidence: 99%