Background: Hemorrhoid is the anal disease and causes major morbidity and economic burden. Surgical treatment causes major complications. Injection Sclerotherapy is widely used in the treatment of hemorrhoids. So the present study was carried out to find the comparative effectiveness of Injection Sclerotherapy using Polidocanol for the management of second and third degree hemorrhoids. Methods: A total of 50 patients reported to the surgical outpatient department of Government Medical College, Dungarpur with second and third degree hemorrhoids were included in this study. The patients were divided into two groups ie. Second and third degree hemorrhoids (n=25). Injection polidocanol was used for the Sclerotherapy with three doses at an interval of 3 weeks. Results: In the present study most of the patients were in the age range of 51-60 year and male preponderance was high. In second degree hemorrhoids patients 96% displayed satisfactory relief as compared to third degree hemorrhoids patients only 72% elicited satisfactory outcome. Conclusion: Thus injection Sclerotherapy using Polidocanol elicits good results with less complications and low cost. Further, the results have shown that this method is effective in second degree hemorrhoids as that of the third degree hemorrhoids.