Effects and contributory factors of sulfur-fumigation on the efficacy and safety of medicinal herbs evaluated by meta-analysis

Liu, H.; Wang, Siyu; Zhu, Jin-Hao; Kong, Ming; Zhou, Shanshan; Li, Songlin; Zhu, He

doi:10.1016/j.jep.2022.115250

Cited by 10 publications

(1 citation statement)

References 32 publications

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“…Besides, CR is often fumigated with sulfur by profit-seeking herbalists and wholesalers for long-term preservation and maintaining its vivid color. The process of sulfur fumigation can have an impact on the quality, biological activity, pharmacokinetics, and safety of the herbs [17][18][19][20][21]. Researchers have used fingerprint and stoichiometric techniques to distinguish sulfur-fumigated and non-sulfur-fumigated TCMs [22][23][24][25], providing a reference for identifying sulfurfumigated CR.…”

Section: Introductionmentioning

confidence: 99%

Identification of Codonopsis Radix from different sources by integrating high‐performance liquid chromatography fingerprinting with chemometric approaches and Lobetyolin determination

Liu,

Wang

et al. 2024

Separation Science Plus

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Codonopsis Radix (CR) is often used as both a medicine and a food ingredient. However, identifying CR can be difficult due to various factors such as variety, sulfur fumigation, and storage time. Consequently, a comprehensive strategy based on fingerprinting and chemometric approaches was developed to distinguish different CRs. First, the fingerprints of CR were acquired by high‐performance liquid chromatography (HPLC). Secondly, various chemical pattern recognition methods were employed to identify CR. Additionally, 14 and 16 major compounds were identified as marker compounds to differentiate between different varieties and sulfur‐fumigated samples, respectively. Furthermore, the amount of Lobetyolin present in different samples was determined, showing that the content of Lobetyolin varied significantly across the samples. Codonopsis pilosula Nannf. var. modesta (Nannf.) L.T.Shen had the highest content of Lobetyolin, followed by Codonopsis tangshen Oliv., and Codonopsis pilosula (Franch.) Nannf. In addition, the content of Lobetyolin was highest when it was non‐sulfur‐fumigated and stored for 0 years. Conclusively, HPLC fingerprint in conjunction with chemical pattern recognition and component content determination, can be employed to differentiate different varieties and sulfur‐fumigated CR. Additionally, it is a reliable, comprehensive, simple, and rapid method for the identification of CR.

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