Effects and interactions of gallic acid, eugenol and temperature on thermal inactivation of Salmonella spp. in ground chicken

López-Romero, Julio Cesár; Valenzuela‐Melendres, Martín; Juneja, Vijay K.; García-Dávila, Jimena; Camou, Juan Pedro; Peña-Ramos, Aida; González‐Ríos, Humberto

doi:10.1016/j.foodres.2017.10.055

Cited by 28 publications

(10 citation statements)

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“…It has been shown that in addition to its immunomodulatory effect [59], scopoletin reduces the intracellular survival of Salmonella Typhi within U937 human macrophage cell line [60]. Gallic acid has in addition to its in vitro and in vivo antibacterial effect against Salmonella Typhimurium [61,62], an antioxidant activity. These compounds related properties corroborate the findings of Sokoudjou et al [20] who reported that the ability of the extract of Canarium schweinfurthii to cure salmonellosis in broilers could be explained by its ability to directly kill Salmonella and/or boost the immune system of the host.…”

Section: Discussionmentioning

confidence: 99%

Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

Sokoudjou

Atolanı

Njateng

et al. 2020

BMC Complement Med Ther

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Background Bacteria belonging to the Salmonella genus are major concern for health, as they are widely reported in many cases of food poisoning. The use of antibiotics remains a main stream control strategy for avian salmonellosis as well as typhoid and paratyphoid fevers in humans. Due to the growing awareness about drug resistance and toxicities, the use of antibiotics is being discouraged in many countries whilst advocating potent benign alternatives such as phyto-based medicine. The objective of this work was to isolate, characterise the bioactive compounds of Canarium schweinfurthii; and evaluate their anti-salmonellal activity. Methods The hydro-ethanolic extract of Canarium schweinfurthii was fractionated and tested for their anti-salmonellal activity. The most active fractions (i.e. chloroform and ethyl acetate partition fractions) were then explored for their phytochemical constituents. Fractionation on normal phase silica gel column chromatography and size exclusion chromatography on Sephadex LH-20 led to the isolation of four compounds (maniladiol, scopoletin, ethyl gallate and gallic acid) reported for the first time in Canarium schweinfurthii. Results Result indicated that scopoletin and gallic acid had greater activity than the crude extracts and partition fractions. Among the isolated compounds, scopoletin showed the highest inhibitory activity with a MIC of 16 μg/ml against Salmonella Typhimurium and Salmonella Enteritidis. Conclusions The overall results of this study indicates that the hydro-ethanolic extract as well as some of isolated compounds have interesting anti-salmonellal activities that could be further explored for the development of potent therapy for salmonellosis. Furthermore, the study adds credence to the folkloric applications of the plant.

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Section: Discussionmentioning

confidence: 99%

Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

Sokoudjou

Atolanı

Njateng

et al. 2020

BMC Complement Med Ther

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“…Similarly, a study on chickens displayed a synergistic effect of GA and eugenol in reducing the heat lethality of Salmonella spp. (121).…”

Section: Antimicrobial Properties In Vitromentioning

confidence: 99%

Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

et al. 2020

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Gallic acid (GA) is a naturally occurring polyphenol compound present in fruits, vegetables, and herbal medicines. According to previous studies, GA has many biological properties, including antioxidant, anticancer, anti-inflammatory, and antimicrobial properties. GA and its derivatives have multiple industrial uses, such as food supplements or additives. Additionally, recent studies have shown that GA and its derivatives not only enhance gut microbiome (GM) activities, but also modulate immune responses. Thus, GA has great potential to facilitate natural defense against microbial infections and modulate the immune response. However, the exact mechanisms of GA acts on the GM and immune system remain unclear. In this review, first the physicochemical properties, bioavailability, absorption, and metabolism of GA are introduced, and then we summarize recent findings concerning its roles in gastrointestinal health. Furthermore, the present review attempts to explain how GA influences the GM and modulates the immune response to maintain intestinal health.

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“…The phenolic acids evaluated in this study have been previously noted by other researchers, primarily for their roles as antioxidants, documented use as food preservatives, and antimicrobial potential against Gram-negative bacterial pathogens [ 32 ]. GA, PA and VA specifically have been shown to inhibit the growth of Pseudomonas spp., Listeria monocytogenes , Mannheimia haemolytica , Pasteurella multocida , Escherichia coli and some strains of Salmonella spp., as well as being able to reduce the pathogenicity of other bacteria such as Proteus mirabilis [ 33 , 34 , 35 , 36 ]. However, the effectiveness against ST, specifically, has not been consistently documented, in addition to the mechanisms of action underlying the molecular interactions that precede cell death remaining poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and Antivirulence Impacts of Phenolics on Salmonella Enterica Serovar Typhimurium

et al. 2020

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Salmonella enterica serovar Typhimurium (ST) remains a major infectious agent in the USA, with an increasing antibiotic resistance pattern, which requires the development of novel antimicrobials capable of controlling ST. Polyphenolic compounds found in plant extracts are strong candidates as alternative antimicrobials, particularly phenolic acids such as gallic acid (GA), protocatechuic acid (PA) and vanillic acid (VA). This study evaluates the effectiveness of these compounds in inhibiting ST growth while determining changes to the outer membrane through fluorescent dye uptake and scanning electron microscopy (SEM), in addition to measuring alterations to virulence genes with qRT-PCR. Results showed antimicrobial potential for all compounds, significantly inhibiting the detectable growth of ST. Fluorescent spectrophotometry and microscopy detected an increase in relative fluorescent intensity (RFI) and red-colored bacteria over time, suggesting membrane permeabilization. SEM revealed severe morphological defects at the polar ends of bacteria treated with GA and PA, while VA-treated bacteria were found to be mid-division. Relative gene expression showed significant downregulation in master regulator hilA and invH after GA and PA treatments, while fliC was upregulated in VA. Results suggest that GA, PA and VA have antimicrobial potential that warrants further research into their mechanism of action and the interactions that lead to ST death.

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Effects and interactions of gallic acid, eugenol and temperature on thermal inactivation of Salmonella spp. in ground chicken

Cited by 28 publications

References 28 publications

Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

Antimicrobial and Antivirulence Impacts of Phenolics on Salmonella Enterica Serovar Typhimurium

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