Effects and mechanism of action of Huang-Lian-Jie-Du-Tang in atopic dermatitis-like skin dysfunction in vivo and in vitro

Fan, Huijie; Zhao, Xiaoshan; Tan, Zhenghuai; Liu, Bin; Xu, Hui; Wu, Yuting; Xie, Lingpeng; Bi, Ye; Lai, Yigui; Liang, Hongfeng; Zhou, Yingchun

doi:10.1016/j.jep.2019.111937

Cited by 27 publications

(15 citation statements)

References 49 publications

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“…In 2,4-dinitrochlorobenzene-induced atopic dermatitis mice, HLJDD down-regulated serum expression levels of IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, interferongamma and TNF-α, normalised the splenic CD4 + /CD8 + T-lymphocyte ratio, and inactivated MAPKs (including p38, extracellular regulated protein kinases (ERK), and c-Jun N-terminal kinase (JNK)), IκB-α, and NF-κB (p65). Moreover, HLJDD inhibited LPS-induced differentiation of RAW264.7 cells, reduced LPS binding to the RAW264.7 cell membrane, as well as decreased ERK, p38, JNK, IκB-α, and p65 phosphorylation levels in the MAPKs/NF-κB pathway and inhibited p65 nuclear translocation [115]. Further, a study revealed that HLJDD had a positive effect in rat gingivitis induced by LPS.…”

Section: Anti-inflammatory and Anti-allergymentioning

confidence: 90%

“…5. Collagen-induced arthritis rats Regulating fatty acid oxidation and arachidonic acid metabolism [19] LPS-stimulated RAW 264.7 macrophages Suppressing the production of inflammatory mediators via inactivation of NF-κB and MAPKs, and degradation of IκBα [108] Cecal ligation and puncture-induced septic model rats Enhancing cholinergic anti-inflammatory pathway Inhibiting HMGB-1/TLR4/NF-κB signaling pathway [4] Cecal ligation and puncture-induced septic model rats Suppressing the production of proinflammatory cytokines Reversing the shift from Th1 to Th2 response and promote Th1/Th2 balance toward Th1 predominance Iinhibiting Th17 activation [112] 2,4-dinitrochlorobenzene-induced atopic dermatitis mice LPS-stimulated RAW 264.7 macrophages Inhibiting MAPKs/NF-κB pathway [115] LPS-induced gingivitis rats Inhibiting AMPK and ERK1/2 pathway [116] LPS-induced acute kidney injury mice Inhibiting NF-κB and MAPK activation Activating Akt/HO-1 pathway Ameliorating disturbances in oxidative stress and energy metabolism [26] Anti-allergy Antigen-induced RBL-2H3 cells Suppressing allergic mediators via inactivation of MAPKs and Lyn pathway [108] Modulation of blood lipid ApoE(-/-) mice Primary bone marrow-derived macrophage Foam cells…”

Section: Anti-tumormentioning

confidence: 99%

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Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

Zhang

Zhu

2019

Chin Med

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Huang-Lian Jie-Du decoction (HLJDD), a famous traditional Chinese prescription constituted by Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri and Fructus Gradeniae, has notable characteristics of dissipating heat and detoxification, interfering with tumors, hepatic diseases, metabolic disorders, inflammatory or allergic processes, cerebral diseases and microbial infections. Based on the wide clinical applications, accumulating investigations about HLJDD focused on several aspects: (1) chemical analysis to explore the underlying substrates responsible for the therapeutic effects; (2) further determination of pharmacological actions and the possible mechanisms of the whole prescription and of those representative ingredients to provide scientific evidence for traditional clinical applications and to demonstrate the intriguing molecular targets for specific pathological processes; (3) pharmacokinetic feature studies of single or all components of HLJDD to reveal the chemical basis and synergistic actions contributing to the pharmacological and clinically therapeutic effects. In this review, we summarized the main achievements of phytochemical, pharmacological and pharmacokinetic profiles of HLJDD and its herbal or pharmacologically active chemicals, as well as our understanding which further reveals the significance of HLJDD clinically.

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Section: Anti-inflammatory and Anti-allergymentioning

confidence: 90%

Section: Anti-tumormentioning

confidence: 99%

Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

Zhang

Zhu

2019

Chin Med

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“…The regulation of Th2 differentiation was studied by measuring the extent of IL-4-, FcεR-, and p-NF-κB p65-positive reactions in the immunohistochemical analysis (Figure 5). TSLP overexpression results in allergic inflammation as well as Th2-skewed conditions after a series of processes involving IL-4, FcεR, and p-NF-κB p65 [27][28][29][30][31]. Immunohistochemistry results showed that IL-4-, FcεR-, and p-NF-κB p65-positive reactions in the LBE, PEAT, and 3HbT groups were higher than those in the Ctrl group, and those in the 3HbT group were lower than those in the LBE and PEAT groups (p < 0.05).…”

Section: Regulation Of Th2 Differentiationmentioning

confidence: 99%

Effect of Coptischinensis, Glycyrrhiza uralensis, and Fermented Glycine max Extract as Proactive Therapy for Atopic Dermatitis

et al. 2021

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The aim of this study was to investigate the effect of the Coptis chinensis, Glycyrrhiza uralensis, and fermented Glycine max (3Hb) extract on lipid barrier recovery and the alleviation of atopic dermatitis (AD). The 3Hb extract was administered to lipid barrier-eliminated mice (3HbT) for 5 days. Subsequently, the effect of the 3Hb extract on general skin features and the regulation of filaggrin, inflammatory response, Th2 differentiation, and the skin micro-environment for defense, was evaluated. In the 3HbT, filaggrin was effectively recovered. The clinical skin score was significantly lower in the 3HbT compared with control groups. In addition, significant decreases in pH and TEWL as well as in the levels of kallikrein 7, PAR-2, TSLP, IL-4, Fc ε receptor, and phosphate-NF-κB p65 were observed in the 3HbT, compared with the other control groups. Further, compared with control groups, the 3HbT showed a significant increase in those of claudin, cathelicidin, TLR, and NHE-1. Our results indicated that the 3Hb extract effectively recovered filaggrin. Through the recovery of filaggrin, inflammation and the Th2 differentiation process can be regulated, and microenvironments for defense can be recovered. Therefore, we confirmed the potential of the 3Hb extract for use in the proactive therapy of AD.

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“…In dextran sulphate sodium-induced mice ulcerative colitis (UC), HLJD decoction alleviates the UC symptoms and decreases inflammatory cytokines in colons [11]. HLJD decoction mitigates mice atopic dermatitis induced by 2,4-dinitrochlorobenzene [12] and decreases nitric oxide and various cytokines release in LPS-stimulated RAW264.7 cells [13]. Taken together, HLJD decoction shows its effects in various inflammatory conditions.…”

Section: Introductionmentioning

confidence: 98%

Efficacy and Safety of Modified Huang-Lian-Jie-Du Decoction Cream on Cancer Patients with Skin Side Effects Caused by EGFR Inhibition

et al. 2021

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(1) Background: The epidermal growth factor inhibitors (EGFRIs)/tyrosine kinase inhibitors (TKIs) are effective for cancer target therapy, but acneiform rashes or so-called inflammatory papulopustular exanthemas are common (50% to 90%). The conventional therapy for EGFRIs/TKIs-induced skin toxicity is steroids and antibacterial drugs, but it is still ineffective for some patients, and EGFRIs/TKIs dose reduction/interruption may be needed. In this study, a modified Chinese herbal medicine, Huang-Lian-Jie-Du decoction cream with Yin-Cold (YC) medicine characteristic, was investigated for the effect on patients suffering EGFRIs/TKIs-induced skin toxicity. (2) Methods: The modified Huang-Lian-Jie-Du (mHLJD) decoction cream was made from 10 herbal medicines, including 4 major medicines (Huanglian, Huangqin, Huangbo, and Zhizi) in traditional HLJD decoction. Patients with EGFRIs/TKIs-induced skin toxicity were enrolled. Patients were excluded if they also used other cream for skin toxicity. Skin conditions were monitored by follow up every 2 weeks. The patients’ characteristics, the skin toxicities, treatment response, and adverse events were recorded and analyzed until skin problems resolved or the study ended. (3) Results: The mHLJD decoction cream and its sub-packages were stored at 4 °C before use. Thirty-four patients who had grade 1–3 skin toxicities after receiving EGFRIs/TKIs were enrolled. Seven patients withdrew or were excluded. Finally, data from 27 patients were analyzed. The mean grade of rash acneiform was significantly decreased from 2.19 (ranged 1 to 3) to 0.88 (ranged 0 to 2) after mHLJD decoction cream treatment for 4 weeks and to 0.55 (ranged 0 to 2) after mHLJD decoction cream treatment for 8 weeks. Additionally, the mean grade of dry skin was also significantly decreased from 1.57 (ranged 1 to 2) to 0.71 (ranged 0 to 1) after mHLJD decoction cream treatment for 4 weeks. The changes of skin toxicity were significant, with no obvious adverse events. (4) Conclusions: In summary, the mHLJD decoction cream provides benefits for alleviation of EGFRIs/TKIs-induced skin rash acneiform and dry skin. Additionally, no obvious side effects were found in patients using mHLJD decoction cream.

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Effects and mechanism of action of Huang-Lian-Jie-Du-Tang in atopic dermatitis-like skin dysfunction in vivo and in vitro

Cited by 27 publications

References 49 publications

Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

Effect of Coptischinensis, Glycyrrhiza uralensis, and Fermented Glycine max Extract as Proactive Therapy for Atopic Dermatitis

Efficacy and Safety of Modified Huang-Lian-Jie-Du Decoction Cream on Cancer Patients with Skin Side Effects Caused by EGFR Inhibition

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