Effects and mechanism of platelet-rich plasma on military drill injury: a review

Xu, Pengcheng; Xuan, Ming

doi:10.1186/s40779-020-00285-1

Cited by 12 publications

(10 citation statements)

References 73 publications

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“…Bioelectrical impedance analysis-guided fluid resuscitation in post-traumatic open abdomen patients managed to achieve a higher primary fascial closure rate and fewer complications compared to traditional resuscitation strategy [50]. In the military setting, Xu et al [51] reviewed the literature on the role of platelet-rich plasma (PRP) on military drill injury, as well as discussed the pros and cons and surrounding controversies of PRP therapy. While there seems to be existing limitations to the use of PRP, the minimally-invasive nature of the treatment and its potential benefits make it an attractive option in the therapeutic armamentarium.…”

Section: Advances In Wound Healingmentioning

confidence: 99%

Pushing the frontiers of military medical excellence: updates, progress and future needs

Seah

Wang

2022

Military Med Res

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Since its establishment in 2014, MilitaryMedicalResearch has come a long way in becoming a premier journal for scientific articles from various different specialties, with a special emphasis on topics with military relevance. The field of military medicine may be obscure, and may not be readily encountered by the typical clinician on a day-to-day basis. This journal aims not only to pursue excellence in military research, but also keep current with the latest advancements on general medical topics from each and every specialty. This editorial serves to recap and synthesize the existing progress, updates and future needs of military medical excellence, discussing foremostly the unique traits of literature published in this journal, and subsequently presenting the discourse regarding wartime and peacetime medicine, the role of the military in a public health emergency, as well as wound healing and organ regeneration. Special attention have been devoted to military topics to shed light on the effects of Chemical, Biological, Radiological and Explosive (CBRE) warfare, environmental medicine and military psychiatry, topics which rarely have a chance to be discussed elsewhere. The interconnectedness between military combat and soldier physical and mental well-being is intricate, and has been distorted by pandemics such as coronavirus disease 2019 (COVID-19). This journal has come a long way since its first article was published, steadily contributing to the existing knowledge pool on general medical topics with a military slant. Only with continuous research and sharing, can we build upon the work of the scientific community, with hopes for the betterment of patient care.

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Section: Advances In Wound Healingmentioning

confidence: 99%

Pushing the frontiers of military medical excellence: updates, progress and future needs

Seah

Wang

2022

Military Med Res

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“…21 Upon activation, these platelets release an array of growth factors and cytokines. 22 Remarkably, PRP inherently serves as a growth factor carrier, negating the need for external mediums. 2 Bones, naturally endowed with a potent regenerative capacity, utilize cellular components, growth factors, and elements of the extracellular matrix for restoratio.…”

Section: Growth Factor Dynamics Of Prp In Osteogenesismentioning

confidence: 99%

Platelet-rich plasma in orthopedics: Bridging innovation and clinical applications for bone repair

Zhu,

Li,

Qin

et al. 2024

J Orthop Surg (Hong Kong)

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In the burgeoning domain of orthopedic therapeutic research, Platelet-Rich Plasma (PRP) has firmly established its position, transforming paradigms ranging from tissue regeneration to the management of chondral lesions. This review delves into PRP’s recent integrations with cutting-edge interventions such as 3D-printed scaffolds, its role in bone and cartilage defect management, and its enhanced efficacy when combined with molecules like Kartogenin (KGN) for fibrocartilage zone repair. Significant attention is paid to tissue engineering for meniscal interventions, where a combination of KGN, PRP, and bone marrow-derived mesenchymal stem cells are under exploration. Within the sphere of osteochondral regenerative therapy, the synergy of PRP with Bone Marrow Aspirate Concentrate (BMAC) represents a noteworthy leap towards cartilage regeneration. The innovative incorporation of PRP with biomaterials like hydroxyapatite and graphene oxide further underscores its versatility in supporting structural integrity and ensuring sustained growth factor release. However, while PRP’s autologous and nontoxic nature makes it an inherently safe option, concerns arising from its preparation methods, particularly with bovine thrombin, necessitate caution. As of 2023, despite the burgeoning promise of PRP in bone healing, the quest for its standardization, optimization, and substantiation through rigorous clinical trials continues. This comprehensive review elucidates the contemporary applications, challenges, and future trajectories of PRP in orthopedics, aiming to spotlight areas primed for further research and exploration.

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“…Therefore, a new therapeutic tool, platelet-rich plasma (PRP) technology, has been developed because of the presence of large amounts of GFs in platelets, which can be used for DU repair. PRP is a platelet concentrate obtained by centrifugation of a patient's fresh peripheral blood [ 259 ]. Wei et al loaded PRP into an ODex, antimicrobial peptide-modified hyaluronic acid (HA-AMP) hydrogel and confirmed that the hydrogel can promote the proliferation and migration of L929 fibroblasts through CCK-8 assays, live/dead fluorescent staining and scratch tests.…”

Section: Bioactivators For Dusmentioning

confidence: 99%

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Wei

et al. 2023

Biomater Res

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Diabetic ulcers (DUs) are one of the most serious complications of diabetes mellitus. The application of a functional dressing is a crucial step in DU treatment and is associated with the patient's recovery and prognosis. However, traditional dressings with a simple structure and a single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer dressings and hydrogels to solve the therapeutic bottleneck of DU treatment. Hydrogels are a class of gels with a three-dimensional network structure that have good moisturizing properties and permeability and promote autolytic debridement and material exchange. Moreover, hydrogels mimic the natural environment of the extracellular matrix, providing suitable surroundings for cell proliferation. Thus, hydrogels with different mechanical strengths and biological properties have been extensively explored as DU dressing platforms. In this review, we define different types of hydrogels and elaborate the mechanisms by which they repair DUs. Moreover, we summarize the pathological process of DUs and review various additives used for their treatment. Finally, we examine the limitations and obstacles that exist in the development of the clinically relevant applications of these appealing technologies. Graphical Abstract This review defines different types of hydrogels and carefully elaborate the mechanisms by which they repair diabetic ulcers (DUs), summarizes the pathological process of DUs, and reviews various bioactivators used for their treatment.

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Effects and mechanism of platelet-rich plasma on military drill injury: a review

Cited by 12 publications

References 73 publications

Pushing the frontiers of military medical excellence: updates, progress and future needs

Pushing the frontiers of military medical excellence: updates, progress and future needs

Platelet-rich plasma in orthopedics: Bridging innovation and clinical applications for bone repair

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

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