Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats

Chen, Xing-Dong; Wei, Jing-Xiang; Wang, Hai-Yan; Peng, Yu-Yuan; Tang, Can; Ding, Yang; Li, Sen; Long, Zai-Yun; Lu, Xiu-Min; Wang, Yong-Tang

doi:10.1016/j.neuropharm.2023.109728

Neuropharmacology

2023

DOI: 10.1016/j.neuropharm.2023.109728

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Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats

Xing-Dong Chen,

Jing-Xiang Wei,

Hai-Yan Wang

et al.

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2024

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Cited by 4 publications

References 63 publications

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Single‐Nucleus RNA Sequencing Reveals That Gabra6⁺ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI

Fei,

Zhang,

Dou

et al. 2024

Advanced Science

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Shockwave‐induced traumatic brain injury (TBI) results in the onset of post‐traumatic stress disorder (PTSD), triggered either by the TBI itself or other stressors. However, the interplay and underlying mechanisms of how these factors synergistically induce PTSD remain inadequately elucidated. Here, mice in the TBI (induced by biological shock tube blast injury) and PTSD (induced by single prolonged stress method) groups both displayed symptoms of PTSD behaviors, with the TBI+PTSD (composite model) group exhibiting more severe manifestations. The result of snRNA‐seq demonstrated a noticeable increase in the population of Gabra6+ neurons in the prefrontal cortex region of mice in the TBI+PTSD group. Knocking down cortical Gabra6 mitigated PTSD‐related behavioral outcomes. Mechanistically, the Smad3/4 complex activation led to the upregulation of Gabra6 expression in cortical neurons. Interaction of Gabra6 with Homer1 activated downstream cAMP signaling pathways. Homer1KO‐Nestin mice show reduced susceptibility to PTSD. Subsequently, the efficacy of monoclonal antibody intervention at the 218 site of Gabra6 in ameliorating PTSD development is verified. This study suggests that TBI and stressors act as independent components in PTSD development, with Gabra6+ neurons pivotal in synergistically facilitating PTSD formation. Strategies geared toward minimizing exposure to singular or combined stressors may effectively diminish the risk of developing PTSD.

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Single‐Nucleus RNA Sequencing Reveals That Gabra6⁺ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI

Fei,

Zhang,

Dou

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

Medicinal cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway

Shen,

Wang,

et al. 2024

Behavioural Brain Research

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H2S improves hippocampal synaptic plasticity in SPS rats via PI3K/AKT signaling pathway

Yu,

Zhang,

Wang

et al. 2024

Brain Research

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Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats

Cited by 4 publications

References 63 publications

Single‐Nucleus RNA Sequencing Reveals That Gabra6⁺ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI

Single‐Nucleus RNA Sequencing Reveals That Gabra6⁺ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI

Medicinal cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway

H2S improves hippocampal synaptic plasticity in SPS rats via PI3K/AKT signaling pathway

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Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats

Cited by 4 publications

References 63 publications

Single‐Nucleus RNA Sequencing Reveals That Gabra6+ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI

Single‐Nucleus RNA Sequencing Reveals That Gabra6+ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI

Medicinal cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway

H2S improves hippocampal synaptic plasticity in SPS rats via PI3K/AKT signaling pathway

Contact Info

Product

Resources

About

Single‐Nucleus RNA Sequencing Reveals That Gabra6⁺ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI

Single‐Nucleus RNA Sequencing Reveals That Gabra6⁺ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI