Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice

Abstract

Silibinin reduces HCC xenograft growth through the inhibition of cell proliferation, cell cycle progression and PTEN/P-Akt and ERK signaling, inducing cell apoptosis, and increasing histone acetylation and SOD-1 expression.

Silibinin Induces Cell Death through Reactive Oxygen Species–Dependent Downregulation of Notch-1/ERK/Akt Signaling in Human Breast Cancer Cells

“…3C). Similar results have been reported from hepatocellular carcinoma (Cui et al, 2009) and human fibrosarcoma (Duan et al, 2011).…”

Increase of Phosphatase and Tensin Homolog by Silymarin to Inhibit Human Pharynx Squamous Cancer

“…It has also been suggested that silibinin, another component of milk thistle extract, significantly increases PTEN expression resulting in a decrease of p-Akt production in hepatic tumor. 24 This action of silymarin is consistent with that observed in cervical cancer cell. 28 However, in the present study, silymarin showed a higher potency than silibinin to induce apoptotic cell death in oral cancer cells.…”

“…23 Also, it has been indicated that silibinin significantly increased PTEN expression and activity that was further associated with reduced p-Akt production in HCC xenograft tissue. 24 However, the anti-cancer effect of silymarin related to PTEN expression is still obscure. The current study investigated the effect of silymarin on oral cancer and investigated the potential mechanism(s) relating to PTEN/PI3K/Akt pathway.…”

Sensitization of rhTRAIL-resistant Triple-negative Breast Carcinoma Through Silibinin Co-Treatment

“…Silibinin decreased survivin expression in laryngeal squamous cell cancer cells and glioma cancer cells; silibinin downregulated c-FLIP expression in human glioma cells (14,15). Silibinin decreased hepatocellular and lung carcinoma xenografts in vivo (16,17). All these are encouraging results that make silibinin a safe and promising candidate for cotreatment with rhTRAIL.…”