Effects and Mechanisms of Tea for the Prevention and Management of Diabetes Mellitus and Diabetic Complications: An Updated Review

Meng, Jin-Ming; Cao, Shiyu; Wei, Xinlin; Gan, Ren‐You; Wang, Yuanfeng; Cai, Shumin; Xu, Xiaoyu; Zhang, Pangzhen; Li, Hua-Bin

doi:10.3390/antiox8060170

Cited by 127 publications

(80 citation statements)

References 154 publications

(158 reference statements)

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“…Previous studies have revealed that the consumption of tea is inversely associated with the risk of diabetes mellitus and its complications. Experimental studies have shown that tea has protective effects against diabetes by enhancing insulin action, ameliorating insulin resistance, scavenging free radicals, and decreasing inflammation 30 . Our results indicated that people who were obese (BMI) and had an unfavourable dietary quality had a high risk of prediabetes, and abdominal obesity and obesity (BMI) are significantly associated with an increased risk of diabetes, as they can cause abnormal glucose metabolism 31 .…”

Section: Discussionmentioning

confidence: 99%

Association between Dietary Quality and Prediabetes based on the Diet Balance Index

Qiao

Xiong

et al. 2020

Sci Rep

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Dietary quality is an important factor influencing prediabetes, but few studies have applied the Chinese Diet Balance Index (DBI-16) to evaluate the dietary quality of individuals with prediabetes and explore the associations between dietary quality and prediabetes. In our study, the lower-bound score, higherbound score and diet quality distance, were respectively calculated to assess dietary quality based on each food group. Logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (95%CI) of unfavorable dietary quality leading to prediabetes in every subgroup. The results were shown that individuals with prediabetes had excessive intake in the categories of cereals, salt and inadequate intake in vegetables, fish and diet variety than participants without prediabetes (all p < 0.01). Unfavourable dietary quality was significantly associated with an increased risk of prediabetes (OR: 1.45, 95%CI: 1.29-1.63), especially among the subjects who lived in rural areas (OR: 1.63, 95%CI: 1.25-1.76), those who had abdominal obesity (OR: 1.58, 95%CI: 1.36-1.85), those who smoked (OR: 1.58, 95%CI: 1.30-1.93), those who consumed alcohol (OR: 1.57, 95%CI: 1.28-1.93) and those who did not drink tea (OR: 1.64, 95%CI: 1.42-1.88). In Conclusion, unfavourable dietary quality was significantly associated with an increased risk of prediabetes.Prediabetes and diabetes have become a serious global problem in recent decades, along with the development of the social economy and changes in people's lifestyles. Prediabetes is characterised by glucose levels that do not meet the criteria for diabetes but that are too high to be considered normal 1 . The International Diabetes Federation (IDF) reported that there were approximately 350 million people with prediabetes worldwide and 48.6 million people with prediabetes in China 2 . People with prediabetes have a high risk of developing diabetes, and 70~90% of individuals with prediabetes will eventually develop diabetes 3 .Dietary quality is an important factor influencing prediabetes and diabetes. Healthier dietary intake can reduce the risk of the progression from prediabetes to diabetes by 40~70% 3 . Among people with prediabetes who changed their dietary model, 40.5% achieved normal glucose tolerance, and their fasting plasma glucose level, body mass index (BMI), glycated haemoglobin (HbA1C) level and blood pressure decreased significantly as well 4 . Therefore, several dietary evaluation indexes have been developed around the world in recent years. In China, researchers mainly use the Diet Balance Index-16 (DBI-16) to assess human dietary quality, and the index was updated based on the latest Chinese Dietary Guidelines and the Chinese Balanced Diet Pagoda 5 . The DBI-16 can be used to evaluate the overall dietary quality mainly through three indicators: the lower-bound score (LBS), higher-bound score (HBS), and diet quality distance (DQD). The LBS represents insufficient intake, HBS represents excessive intake and DQD represents the overall imbalance of the...

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Section: Discussionmentioning

confidence: 99%

Association between Dietary Quality and Prediabetes based on the Diet Balance Index

Qiao

Xiong

et al. 2020

Sci Rep

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“…Several studies had confirmed the toxic effects of aflatoxicosis in the different body systems through its direct effect in liberating the reactive oxygen species (ROS) causing cellular damages (Josse, Dumont, Fautre, Robin, & Guillouzo, 2012). Black tea (BTE) was known for its antioxidant effects (Kumar & Rizvi, 2014), it mitigates the aflatoxicosis via several evidences, that is, normalizing the concentrations of total proteins, AST, and ALT (Jha et al., 2013), and lowering the hypercholesterolemia (Troup et al, 2015) and nephropathy (Meng et al., 2019). Likewise, Suryanarayana, Satyanarayana, Balakrishna, Kumar, and Reddy (2007) and Tokaç et al.…”

Section: Discussionmentioning

confidence: 99%

Black tea and curcumin synergistically mitigate the hepatotoxicity and nephropathic changes induced by chronic exposure to aflatoxin‐B1 in Sprague–Dawley rats

et al. 2020

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The study aimed to clarify the characteristics of black tea (BTE) and/or curcumin (CMN) against aflatoxin‐B1 (AFB1). Forty eight adult male Sprague–Dawley rats were divided into eight groups. G1 was non‐treated control. G2, G3, and G4 were olive oil, BTE, and CMN, respectively. G5 was olive oil‐dissolved AFB1 (25 µg/kg b.w). G6, G7, and G8 were AFB1 along with BTE (2%), CMN (200 mg/kg b.w.), and BTE plus CMN, respectively. All treatments were orally given for consecutive 90 days. After treatment period, rats were sacrificed. Serobiochemical analysis and histopathology showed hepatorenal dysfunction in response to AFB1. Glutathione‐antioxidants were significantly decreased versus increased lipid peroxides (p < .05–.001). AFB1 significantly increased the expression of the antitumor p53, but decreased that of antiapoptotic Bcl2 in liver or kidney tissue, either (p < .05). BTE or CMN ameliorated those changes induced by AFB1 in both liver and kidney with highly pronounced improvement when combined BTE/CMN was used. Practical applications Black tea (BTE) and curcumin (CMN) were known for their antioxidant effects, and several studies reported their independent effects against different toxicities including aflatoxicosis. The current study clarifies the ameliorative characteristics of both agents; BTE and/or CMN, against the toxicity resulted from the chronic exposure to aflatoxin‐B1 (AFB1) (25 µg/kg b.w. for consecutive 90 days). The dose of either agents, BTE or CMN, was 200 mg/kg b.w. along with AFB1. The pathologic changes, serobiochemical parameters, oxidative stress, histological changes, and the molecular disruption, induced by AFB1 in both liver and kidney were obviously and significantly ameliorated after BTE and/or CMN treatments in variable potencies where both agents showed the most effective antitoxic capacities.

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“…This indicates a protective effect of EGCG on pancreatic cell function. Meng et al showed that EGCG can inhibit inflammation by reducing reactive oxygen species and downregulating the production of inducible nitric oxide synthetase (iNOS) [56]. Furthermore, EGCG increases glucose tolerance [57] and decrease HbA1c levels in STZ-induced diabetes in rats, contributing to further prevention of diabetic complications [58].…”

Section: Protective Effects Of Egcg On Pancreatic and Hepatic Cell Fumentioning

confidence: 99%

The Effect of Nano-Epigallocatechin-Gallate on Oxidative Stress and Matrix Metalloproteinases in Experimental Diabetes Mellitus

et al. 2020

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Background: The antioxidant properties of epigallocatechin-gallate (EGCG), a green tea compound, have been already studied in various diseases. Improving the bioavailability of EGCG by nanoformulation may contribute to a more effective treatment of diabetes mellitus (DM) metabolic consequences and vascular complications. The aim of this study was to test the comparative effect of liposomal EGCG with EGCG solution in experimental DM induced by streptozotocin (STZ) in rats. Method: 28 Wistar-Bratislava rats were randomly divided into four groups (7 animals/group): group 1—control group, with intraperitoneal (i.p.) administration of 1 mL saline solution (C); group 2—STZ administration by i.p. route (60 mg/100 g body weight, bw) (STZ); group 3—STZ administration as before + i.p. administration of EGCG solution (EGCG), 2.5 mg/100 g b.w. as pretreatment; group 4—STZ administration as before + i.p. administration of liposomal EGCG, 2.5 mg/100 g b.w. (L-EGCG). The comparative effects of EGCG and L-EGCG were studied on: (i) oxidative stress parameters such as malondialdehyde (MDA), indirect nitric oxide (NOx) synthesis, and total oxidative status (TOS); (ii) antioxidant status assessed by total antioxidant capacity of plasma (TAC), thiols, and catalase; (iii) matrix-metalloproteinase-2 (MMP-2) and -9 (MMP-9). Results: L-EGCG has a better efficiency regarding the improvement of oxidative stress parameters (highly statistically significant with p-values < 0.001 for MDA, NOx, and TOS) and for antioxidant capacity of plasma (highly significant p < 0.001 for thiols and significant for catalase and TAC with p < 0.05). MMP-2 and -9 were also significantly reduced in the L-EGCG-treated group compared with the EGCG group (p < 0.001). Conclusions: the liposomal nanoformulation of EGCG may serve as an adjuvant therapy in DM due to its unique modulatory effect on oxidative stress/antioxidant biomarkers and MMP-2 and -9.

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Effects and Mechanisms of Tea for the Prevention and Management of Diabetes Mellitus and Diabetic Complications: An Updated Review

Cited by 127 publications

References 154 publications

Association between Dietary Quality and Prediabetes based on the Diet Balance Index

Association between Dietary Quality and Prediabetes based on the Diet Balance Index

Black tea and curcumin synergistically mitigate the hepatotoxicity and nephropathic changes induced by chronic exposure to aflatoxin‐B1 in Sprague–Dawley rats

The Effect of Nano-Epigallocatechin-Gallate on Oxidative Stress and Matrix Metalloproteinases in Experimental Diabetes Mellitus

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