Effects and safety of perfluorohexyloctane on the eye surface and corneal endothelium

Orobia, A.J. Mateo; Blasco-Martínez, Alejandro; Rodríguez-Ausín, P.; Júlvez, Luis Pablo; Villahoz, N. Güemes; Sanz, Eduardo del Prado; Palacián, M. Satué; Benítez-del-Castillo, J.M.

doi:10.1016/j.oftale.2020.05.015

Cited by 1 publication

(2 citation statements)

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“…was standardized to avoid any environmental variation along the procedures. As F6H8 does not induce corneal punctate ( 14 ), fluorescein corneal staining was considered not necessary. This way, the observed effects of F6H8 were not masked or affected by fluorescein or its excipients.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, in mild to moderate DED patients F6H8 transiently increases tear film thickness 10 min after its application ( 13 ). A more recent study showed that topical treatment with F6H8 does not induce changes in corneal endothelium and significantly reduce corneal staining in DED patients, supporting its effectiveness and safety ( 14 ).…”

Section: Introductionmentioning

confidence: 95%

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Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and Pain

et al. 2021

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Perfluorohexyloctane (F6H8) eyedrops have been recently introduced in Europe as a product to treat dry eye disease, based on its ability to reduce tear film instability in Meibomian gland dysfunction and evaporative dry eye disease, although its mechanism of action is still unknown. In the present pilot study, we evaluated the effects of the ocular instillation of a single drop of commercial F6H8 eyedrops in 20 healthy humans (9 women/11 men), measuring: (a) Corneal surface temperature (CST) from infrared video images; (b) tear volume using phenol red threads; (c) blinking frequency; and (d) ocular surface sensations (cold, dryness, pricking, foreign body, burning, itching, gritty, eye fatigue, watering eyes, and light-evoked discomfort sensations; scored using 10 cm Visual Analog Scales), before and 5–60 min after F6H8 or saline treatment. CST decreased and tearing and blinking frequency increased significantly after F6H8 but not after saline solution. When applied unilaterally, CST decreased only in the F6H8-treated eye. No sensations were evoked after F6H8 or saline. The corneal surface temperature reduction produced by topical F6H8 does not evoke conscious ocular sensations but is sufficient to increase the activity of corneal cold thermoreceptors, leading to an increased reflex lacrimation and blinking that may relieve dry eye condition thus reducing ocular discomfort and pain.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%