1975
DOI: 10.1002/tera.1420120207
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Effects in mice of high and low environmental temperature on the maternal and fetal toxicity of 2‐sec‐butyl‐4,6‐dinitrophenol (dinoseb) and on disposition of [14C]‐dinoseb

Abstract: Swiss-Webster female mice were treated with 2-sec-butyl-4,6-dinitrophenol (dinoseb) and maintained in an increased environmental temperature (32 degrees C) for 24 h or a decreased temperature (0-6 degrees C) for 1.5-4 h. In two experiemtns animals maintained at low temperature were kept wet during the cold exposure, to enhance the reduction in body temperature, by rinsing them with water at approximately 30 min intervals. Results from nonpregnant females indicated that increased temperature lowered the LD50 fo… Show more

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Cited by 13 publications
(8 citation statements)
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“…Prenatal i.p. and s.c. doses of dinoseb induced growth retardation, embryolethality and/or teratogenicity at or over the maternally toxic dose levels (10-20 mg/kg bw/day) in SwissWebster mice (Gibson, 1973;Preache & Gibson, 1975a;Preache & Gibson, 1975b). Prenatal i.p.…”
Section: Discussionmentioning
confidence: 97%
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“…Prenatal i.p. and s.c. doses of dinoseb induced growth retardation, embryolethality and/or teratogenicity at or over the maternally toxic dose levels (10-20 mg/kg bw/day) in SwissWebster mice (Gibson, 1973;Preache & Gibson, 1975a;Preache & Gibson, 1975b). Prenatal i.p.…”
Section: Discussionmentioning
confidence: 97%
“…Therefore, it is likely that the proximate toxicant for maternal toxicity was dinoseb itself. Swiss-Webster mice were treated with dinoseb on GDs 9-11 and maintained at an increased environmental temperature (32 °C) for 24 h or a decreased temperature (0-6 °C) for 1.5-4 h (Preache & Gibson, 1975b). Exposure to 32 °C enhanced adverse effects of dinoseb; it increased maternal mortality, decreased fetal body weight and increased the incidence of fetal anomalies at 7.5 mg/kg bw/day.…”
Section: Intraperitoneal Studies In Micementioning
confidence: 99%
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“…The effects in mice of high and low environmental tem perature on the maternal and fetal toxicity of dinoseb and on the disposition of dinoseb were studied by Preache and Gibson (1975). SwissWebster female mice dosed with dinoseb were maintained at an increased environmental temperature (32°C) for 24 h or a decreased temperature (0-6°C) for 1.5-4 h. Increased temperature lowered the LD 50 for single injections of dinoseb and reduced temperature had no effect on the LD 50.…”
Section: Other Social or Psychological Factorsmentioning
confidence: 99%