Effects of 1,8-Dihydroxyanthraquinone on Different Segments of Rabbit Gastrointestinal Tract

Eickholt, Theodore H.; Courville, Nolan D.; Danna, Lawrence J.; Verzwyvelt, Lynn J.; Waguespack, Gerald P.

doi:10.1002/jps.2600581035

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“…The fact that isolated colonic tissue from in vivo sennoside-pretreated rats gave less significant val ues of reduced contractility may be a conse quence of the isolation procedure and the following registration of spontaneous con tractility without further drug addition. Re duced motility patterns after sennoside treatment of rats in vivo could be demon strated by continuous recording techniques [7]In intestinal preparations of rabbits a gen eral decrease of the amplitude, frequency and interval of contractions has been docu mented after addition of 1,8-dihydroxyanthraquinone similar to our results with rhein-Na [5].…”

Section: Discussionsupporting

confidence: 77%

In vitro Effects of Anthraquinones on Rat Intestine and Uterus

Odenthal¹,

Ziegler²

1988

Pharmacology

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Isolated uterus and colon segments were taken from sennoside-pretreated female rats. They indicate a possible decrease in spontaneous contractility of both organ segments. Addition of rhein-Na, as one of the probable active metabolites of sennosides, into the bath medium of isolated colon and ileum segments of untreated rats showed a reduction in contractility at concentrations of more than 10^–5 and 10^–4 mol/l, respectively. Though rhein-Na in concentrations of more than 10^–4 mol/l impaired acetylcholine-mediated contractures of isolated colon, the antagonism was obviously partial and noncompetitive. Isolated uteri from previously estrogen-treated rats did not show a change in the contractile behaviour up to concentrations of 10^–4 mol/l rhein-Na, whereas higher concentrations induced an increase in contractions. The importance of this finding is not clear.

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Section: Discussionsupporting

confidence: 77%