The present study aims at evaluating the effects of radiation 900 MHz (Nokia 3310, power 0.96 W/kg, intensity 1.3 × 10 parameters: White blood cells (WBC), Red blood cells (RBC), Hemoglobin (HB), Mean corpuscular volume (MCV), Mean c (MCHC), and Platelet count (PLT), Lymphocyte (LYM), Erythrocyte sedimentation rate (ESR), blood film, and osmotic fragility. Thirty adult male albino mice (25 equal groups; A, B, and C. Group A was used as a control one, group B was exposed to EMR for 1hr day, and Group C was exposed to EMR for 2hr day. The exposure time was three weeks, the results showed a reduced number of red blood cells and h important to observe that the number of WBCs and LYM % increased and therefore reduced the damaging effect. Also, the erythrocyte sedimentation rate was faster than that of the control group. These results were supported by histology of blood cells, where irregularities and deformations in RBCs membranes have occurred. The osmotic fragility test showed a shift towards the low concentration of water after exposure to mobile radiation which indicates changes in could be concluded that mobile radiation has harmful effects on the blood parameters of the exposed mice.