Effects of 1.8 GHz radiofrequency radiation on protein expression in human lens epithelial cells

Zhang, Y; Yao, Ke; Yu, Yibo; Ni, Shuang; Zhang, L; Wang, W; Lai, Kairan

doi:10.1177/0960327112472353

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…Nonetheless, this discrepancy is exciting and warrants further investigation. [56,110,111,112] 22 13 (59.1%) 9 (40.9%) 0.119 Human Leukocytes, human blood neutrophils, human white blood cells [55,69,75,85,113,114,115,116,117,118,119] [171,181,182,183,184,185,186,187,188,189,190] 38 30 (78.9%) 8 (21.1%) 1.779e-04…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of in vitro exposures to weak radiofrequency radiation exposure from mobile phones (1990–2015)

Halgamuge

Skafidas

Davis

2020

Environmental Research

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Section: Resultsmentioning

confidence: 99%

A meta-analysis of in vitro exposures to weak radiofrequency radiation exposure from mobile phones (1990–2015)

Halgamuge

Skafidas

Davis

2020

Environmental Research

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“…The latter is exemplified by CYP21A2, which is necessary for the mineralocorticoid and glucocorticoid production in the adrenal glands, and whose deficiency leads to most cases of congenital adrenal hyperplasia (Miller and Auchus, 2011). Recently several pathogenic variants of CYP21A2 have been linked to autosomal dominant congenital cataracts (Berry et al, 2022), and earlier CYP21A2 was detected in cultures of human lens epithelial cells (Zhang et al, 2013). Collectively, these findings suggested that CYP21A2 could be important for biosynthesis of aldosterone and cortisol in the lens.…”

Section: Steroidogenic P450smentioning

confidence: 99%

“…Conversely, a different group found that 19,20-EDP and 17,18-EEQ suppressed laser-induced CNV in mice ( Yanai et al, 2014 ) and that animals overexpressing CYP2C8 in endothelial cells and fed the DHA+EPA-enriched diet had markedly attenuated neovascular lesions ( Hasegawa et al, 2017 ). Apparently, the individual effects of 19,20-EDP, 14,15-EET, and 17,18-EEQ on ocular neovascularization need to be investigated to resolve the conflicting data on the CYP2C8 ocular significance.…”

Section: Introductionmentioning

confidence: 99%

Challenges and Opportunities in P450 Research on the Eye

Pikuleva

2023

Drug Metab Dispos

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Of the 57 cytochrome P450 enzymes found in humans, at least 30 have ocular tissues as an expression site. Yet knowledge of the roles of these P450s in the eye is limited, in part because only very few P450 laboratories expanded their research interests to studies of the eye. Hence the goal of this review is to bring attention of the P450 community to the eye and encourage more ocular studies. This review is also intended to be educational for eye researchers and encourage their collaborations with P450 experts. The review starts with a description of the eye, a fascinating sensory organ, and is followed by sections on ocular P450 localizations, specifics of drug delivery to the eye, and individual P450s, which are grouped and presented based on their substrate preferences. In sections describing individual P450s, available eye-relevant information is summarized and concluded by the suggestions on the opportunities in ocular studies of the discussed enzymes. Potential challenges are addressed as well. The conclusion section outlines several practical suggestions on how to initiate eye-related research. SIGNIFICANCE STATEMENT This review focuses on the cytochrome P450 enzymes in the eye to encourage their ocular investigations and collaborations between P450 and eye researchers.

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“…Due to healthy cells also being affected by SRP72 depletion, a drug inhibition of SRP72 is unlikely to be a useful strategy for radiotherapy treatment, but SRP72 levels can be a biomarker for radiosensitivity. Interestingly, an independent study reported that SRP68 expression decreased significantly, suggesting it as a biomarker, in human lens epithelial cells exposed to radiofrequency radiation ( Zhang et al, 2013 ).…”

Section: Srp and Diseasesmentioning

confidence: 99%

Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components

Faoro

Ataide

2021

Front. Mol. Biosci.

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The signal recognition particle (SRP) is a ribonucleoprotein complex fundamental for co-translational delivery of proteins to their proper membrane localization and secretory pathways. Literature of the past two decades has suggested new roles for individual SRP components, 7SL RNA and proteins SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72, outside the SRP cycle. These noncanonical functions interconnect SRP with a multitude of cellular and molecular pathways, including virus-host interactions, stress response, transcriptional regulation and modulation of apoptosis in autoimmune diseases. Uncovered novel properties of the SRP components present a new perspective for the mammalian SRP as a biological modulator of multiple cellular processes. As a consequence of these findings, SRP components have been correlated with a growing list of diseases, such as cancer progression, myopathies and bone marrow genetic diseases, suggesting a potential for development of SRP-target therapies of each individual component. For the first time, here we present the current knowledge on the SRP noncanonical functions and raise the need of a deeper understanding of the molecular interactions between SRP and accessory cellular components. We examine diseases associated with SRP components and discuss the development and feasibility of therapeutics targeting individual SRP noncanonical functions.

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Effects of 1.8 GHz radiofrequency radiation on protein expression in human lens epithelial cells

Abstract: The shotgun proteomics technique can be applied to screen the proteins with differential expression between hLECs exposed to 1.8 GHz RF and hLECs sham-exposed to 1.8 GHz RF, and three protein biomarkers associated with RF radiation were validated by Western blot assay.

Cited by 6 publications

References 25 publications

A meta-analysis of in vitro exposures to weak radiofrequency radiation exposure from mobile phones (1990–2015)

A meta-analysis of in vitro exposures to weak radiofrequency radiation exposure from mobile phones (1990–2015)

Challenges and Opportunities in P450 Research on the Eye

Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components

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