Effects of 1 day of inactivity on insulin action in healthy men and women: interaction with energy intake

Stephens, Brooke R.; Granados, Kirsten; Zderic, Theodore W.; Hamilton, Marc T.; Braun, Barry

doi:10.1016/j.metabol.2010.08.014

Cited by 193 publications

(190 citation statements)

References 31 publications

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“…Hence, it may be that something else is driving the associations, although we adjusted for years of education and occupational physical activity. Experimental studies have shown that prolonged sitting leads to metabolic abnormalities via suppressed action of muscle lipoprotein lipase and insulin, supporting a unique "inactivity physiology" paradigm (37)(38)(39) and hence, we believe that sedentary behaviors may (also) influence health via pathways that are independent of social class.…”

Section: Sitting Time and Adult Cardiorespiratory And Muscular Fitnessmentioning

confidence: 55%

Differential cross-sectional associations of work- and leisure-time sitting, with cardiorespiratory and muscular fitness among working adults

Saidj¹,

Jørgensen²,

Jacobsen³

et al. 2014

Scand J Work Environ Health

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Section: Sitting Time and Adult Cardiorespiratory And Muscular Fitnessmentioning

confidence: 55%

Differential cross-sectional associations of work- and leisure-time sitting, with cardiorespiratory and muscular fitness among working adults

Saidj¹,

Jørgensen²,

Jacobsen³

et al. 2014

Scand J Work Environ Health

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“…Administrative or office work involves sedentary behavior characterized by too much sitting while academic work may require movements to lecture buildings. Too much acute and chronic uninterrupted sitting is associated with impaired cardiometabolic risks independently of physical activity [26] due to low energy expenditure, reduced insulin action [27] and reduced skeletal muscle lipoprotein lipase activity [28]. In this regard, sedentary behaviours could potentially be targeted independently from physical activity and dietary intake interventions to reduce MS in the workplace.…”

Section: Discussionmentioning

confidence: 99%

Disparities in the Prevalence of Metabolic Syndrome (MS) and its Components Among University Employees by Age, Gender and Occupation

Cheserek

Shen

et al. 2014

JCDR

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Background: Metabolic Syndrome (MS), a known risk factor for Cardiovascular Disease (CVD) and type II diabetes is an emerging epidemic in China. Studies carried out on the general population indicate a varied clustering of cardiovascular risks in many parts of the country. However, there is limited data on its prevalence in the working population. Workplace can serve as an important place for prevention, control and management of CVD risks. The aim of this study was to investigate the prevalence of MS and its components among University workers, and determine how the prevalence varied according to sex and occupation.Methods: This was a cross-sectional study of 2,428 University employees (22-60 years) who received an annual clinical examination at the University hospital. Anthropometric measurements, blood pressure, Fasting Plasma Glucose (FPG), and lipid profiles were measured. MS was defined according to the National Cholesterol Education Program Adult Treatment panel III modified criteria.Results: Overall prevalence of MS was 6.1%, higher in males (5.1%) than females (1.1%), and increased with age. The most prevalent MS components in all workers were hypertension (37.9%) and hypertryglyceridemia (20.8%), corresponding rates in males were 28.3% and 16.1% while females had a prevalence of 9.6% and 4.7%. After adjustment for age, administrative work was associated (p<0.05) with increased hypertension (odds ratio (OR) =1.474; 95% confidence interval (CI), 1.146-1.896) and hyperglycemia (OR=1.469; 95% CI, 1.082-1.993) in male workers, and with hypertension (OR=1.492; 95% CI, 1.071-2.080) in females. However, prevalence of hypertryglyceridemia was lower (OR=0.390; 95% CI, 0.204-0.746) in female administrators compared to those in academics. Obesity, MS and reduced High Density Lipoprotein (HDL) cholesterol prevalence was not different (p>0.05) between the two occupations in both sexes. Conclusions:Prevalence of MS and its com ponents was higher in male workers than in females, increased with age, and were more common in administrative workers. The findings support the need for gender and occupation specific health interventions to prevent CVDs and type II diabetes in the workplace.

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“…Recently, experimental studies that have broken up prolonged sitting with short periods of light-or moderateintensity activity have shown a reduction in postprandial glucose and insulin concentrations in both healthy and overweight adults (8)(9)(10)(11). These studies suggest that important health-related metabolic processes occur when individuals transition from sitting to movement (light and moderate intensity).…”

mentioning

confidence: 99%

Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study

et al. 2015

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OBJECTIVETo determine whether breaking up prolonged sitting with short bouts of standing or walking improves postprandial markers of cardiometabolic health in women at high risk of type 2 diabetes. RESEARCH DESIGN AND METHODSTwenty-two overweight/obese, dysglycemic, postmenopausal women (mean 6 SD age 66.6 6 4.7 years) each participated in two of the following treatments: prolonged, unbroken sitting (7.5 h) or prolonged sitting broken up with either standing or walking at a self-perceived light intensity (for 5 min every 30 min). Both allocation and treatment order were randomized. The incremental area under the curves (iAUCs) for glucose, insulin, nonesterified fatty acids (NEFA), and triglycerides were calculated for each treatment condition (mean 6 SEM). The following day, all participants underwent the 7.5-h sitting protocol. RESULTSCompared with a prolonged bout of sitting (iAUC 5.3 6 0.8 mmol/L · h), both standing (3.5 6 0.8 mmol/L · h) and walking (3.8 6 0.7 mmol/L · h) significantly reduced the glucose iAUC (both P < 0.05). When compared with prolonged sitting (548.2 6 71.8 mU/L · h), insulin was also reduced for both activity conditions (standing, 437.2 6 73.5 mU/L · h; walking, 347.9 6 78.7 mU/L · h; both P < 0.05). Both standing (21.0 6 0.2 mmol/L · h) and walking (20.8 6 0.2 mmol/L · h) attenuated the suppression of NEFA compared with prolonged sitting (21.5 6 0.2 mmol/L · h) (both P < 0.05). There was no significant effect on triglyceride iAUC. The effects on glucose (standing and walking) and insulin (walking only) persisted into the following day. CONCLUSIONSBreaking up prolonged sitting with 5-min bouts of standing or walking at a selfperceived light intensity reduced postprandial glucose, insulin, and NEFA responses in women at high risk of type 2 diabetes. This simple, behavioral approach could inform future public health interventions aimed at improving the metabolic profile of postmenopausal, dysglycemic women.

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Effects of 1 day of inactivity on insulin action in healthy men and women: interaction with energy intake

Cited by 193 publications

References 31 publications

Differential cross-sectional associations of work- and leisure-time sitting, with cardiorespiratory and muscular fitness among working adults

Differential cross-sectional associations of work- and leisure-time sitting, with cardiorespiratory and muscular fitness among working adults

Disparities in the Prevalence of Metabolic Syndrome (MS) and its Components Among University Employees by Age, Gender and Occupation

Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study

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