Effects of 10.6-μm laser moxibustion and electroacupuncture at ST36 in a 5-Fu-induced diarrhea rat model

Cheng, Hongbo; Zhao, Ling; Ju, Ziyong; Wang, Fan; Qin, Meng; Mao, Huijuan; Shen, Xueyong

doi:10.1007/s00520-020-05788-0

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…At various time points in the experiment, tissue samples of the heart, lung, liver, kidney, and jejunum were removed; the concentration of TBARSs, GSSG, GSH, GPx, GR, and CAT in various tissues was detected as described by Hafez et al (2021), and changes in water content in various tissues were measured as previously described (Nong et al, 2021; Zhao et al, 2021). Changes in plasma creatine kinase (CK-MB), arterial partial pressure of oxygen (PaO 2 ), alanine aminotransferase (ALT), diamine oxidase (DAO), and creatinine (Cr) were measured to determine the level of organ function as described by Cheng et al (2021).…”

Section: Methodsmentioning

confidence: 99%

Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats

Liu,

Fu,

Jiang

et al. 2023

Pharmacognosy Magazine

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Background After hypovolemic shock caused by severe burns, lipid peroxidation is an important factor in tissue edema and multiorgan dysfunction syndrome (MODS). Many studies have shown that valproic acid (VPA) inhibits lipid peroxidation and reduces tissue and organ injury. Objectives This study investigated whether the VPA treatment of scalded rats reduced tissue edema by inhibiting lipid peroxidation, thereby improving organ function and survival rate. Materials and Methods A total of 60 male Sprague-Dawley rats (weighing: 280–300 g) with a 50% total body surface area (TBSA) full-thickness dermal burn were randomly assigned to the following 3 groups (with 20 rats per group): (I) the no infusion resuscitation (NR) group; (II) the sodium lactate Ringer’s solution (LR) group; and (III) the sodium valproate Ringer’s solution (VR) group. After scalding, the following hemodynamic parameters were measured: Copper2+-Zinc2+-superoxide dismutase (Cu2+-Zn2+-SOD) activity, thiobarbituric acid reactive substances (TBARSs), oxidized glutathione (GSSG), reduced glutathione (GSH), and antioxidant enzyme activities. Organ function parameters and water content were also measured. Another 60 male Sprague-Dawley rats were used to observe the 24-h survival rate of the rats using the same scald model and fluid resuscitation. Results VPA significantly increased the mean arterial pressure (MAP) and cardiac output (CO), and significantly decreased the pulmonary vascular permeability index (PVPI) and extravascular lung water index (ELWI). VPA also increased plasma Cu2+-Zn2+-SOD activity and decreased the plasma TBARS level. VPA reduced the TBARS level and GSSG in various tissues and increased the concentration of GSH. VPA decreased glutathione peroxidase (GPx) and catalase (CAT) activity, but significantly increased glutathione reductase (GR) activity in various tissues. VPA significantly improved organ functions and decreased water content. VPA significantly improved the survival rate, and the 24-h survival rate of the VR group was double that of the LR group. Conclusion Resuscitation with VPA reduced tissue edema, protected visceral functions, and improved the survival rate of rats with severe burn shock (BS) by alleviating lipid peroxidation.

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Section: Methodsmentioning

confidence: 99%

Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats

Liu,

Fu,

Jiang

et al. 2023

Pharmacognosy Magazine

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“…270 Additionally, EA of "ST36" reduced damage to the intestinal barrier function caused by 5-Fu and decreased diarrhea. 271 EA has been demonstrated to alleviate fatigue in breast cancer patients undergoing aromatase inhibitor therapy. 272,291 In a clinical trial involving 300 participants, EA significantly reduced fatigue.…”

Section: Clinical Applications Of Electro-acupuncture In Cancer Therapymentioning

confidence: 99%

“…EA was found to be effective in treating vomiting, 269,290 although its duration of effect was limited 270 . Additionally, EA of “ST36” reduced damage to the intestinal barrier function caused by 5‐Fu and decreased diarrhea 271 …”

Section: Electro‐acupuncture In Cancer Therapymentioning

confidence: 99%

Mechanism and application of acupuncture and electro‐acupuncture associated with cancer therapy

Yang,

Li,

Yang

et al. 2024

MedComm – Oncology

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The rapid progress in cancer treatment, along with the increase in cure and control rates, has led to the gradual acceptance of cancer as a chronic disease. Cancer treatment is comprehensive and long‐term. However, cancer symptoms and treatment side effects can hinder patients' quality of life and adherence to treatment, ultimately impacrefting their long‐term survival. Acupuncture (AC) and electro‐acupuncture (EA) have been widely used to treat various diseases. AC and EA have demonstrated their ability to relieve symptoms and side effects related to cancer treatment. The review provides a brief overview of the historical lineage and basic principles of AC treatment, as well as a detailed exploration of the mechanisms and clinical applications of AC and EA to relieve cancer symptoms and treatment side effects. AC and EA can play a therapeutic role by regulating systems of nervous, endocrine, immune and so on. Clinical studies have demonstrated that AC and EA can effectively relieve pain, postoperative ileus, and other symptoms. The safety of AC and EA has been tested worldwide. Furthermore, we discuss the challenges and future research directions for AC and EA in the field of cancer treatment.

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“…5-Fluorouracil (5-FU) is one of the most effective drugs for chemotherapy in colorectal cancer patients (Fu et al, 2019). However, its use is associated with diarrhea (Cheng et al, 2020). In a recent study, 24-week supplementation with L. rhamnosus GG in colorectal cancer patients who received 5-FU, the frequency of diarrhea was significantly decreased (Osterlund et al, 2007).…”

Section: Probiotics and Colon Cancer In Human Studiesmentioning

confidence: 99%

An Update on the Effects of Probiotics on Gastrointestinal Cancers

Davoodvandi¹,

Fallahi²,

Tamtaji³

et al. 2021

Front. Pharmacol.

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Because of their increasing prevalence, gastrointestinal (GI) cancers are regarded as an important global health challenge. Microorganisms residing in the human GI tract, termed gut microbiota, encompass a large number of living organisms. The role of the gut in the regulation of the gut-mediated immune responses, metabolism, absorption of micro- and macro-nutrients and essential vitamins, and short-chain fatty acid production, and resistance to pathogens has been extensively investigated. In the past few decades, it has been shown that microbiota imbalance is associated with the susceptibility to various chronic disorders, such as obesity, irritable bowel syndrome, inflammatory bowel disease, asthma, rheumatoid arthritis, psychiatric disorders, and various types of cancer. Emerging evidence has shown that oral administration of various strains of probiotics can protect against cancer development. Furthermore, clinical investigations suggest that probiotic administration in cancer patients decreases the incidence of postoperative inflammation. The present review addresses the efficacy and underlying mechanisms of action of probiotics against GI cancers. The safety of the most commercial probiotic strains has been confirmed, and therefore these strains can be used as adjuvant or neo-adjuvant treatments for cancer prevention and improving the efficacy of therapeutic strategies. Nevertheless, well-designed clinical studies are still needed for a better understanding of the properties and mechanisms of action of probiotic strains in mitigating GI cancer development.

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Effects of 10.6-μm laser moxibustion and electroacupuncture at ST36 in a 5-Fu-induced diarrhea rat model

Cited by 6 publications

References 45 publications

Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats

Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats

Mechanism and application of acupuncture and electro‐acupuncture associated with cancer therapy

An Update on the Effects of Probiotics on Gastrointestinal Cancers

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