Effects of 12-week inspiratory muscle training with low resistance in patients with multiple sclerosis: A non-randomised, double-blind, controlled trial

Martín-Sánchez, Carlos; Calvo-Arenillas, J.I.; Iglesias, Fausto J. Barbero; Fonseca, E.; Sánchez‐Santos, José Manuel; Martín-Nogueras, A.M.

doi:10.1016/j.msard.2020.102574

Cited by 9 publications

(8 citation statements)

References 29 publications

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“…Low-intensity IMT applied in pwMS increases inspiratory-expiratory strength more than combined RMT. In addition, this training improves respiratory functions and dyspnea more than conventional breathing exercises [45]. The reason for the decrease in dyspnea is the slowing of respiratory rate and decline in carbon dioxide production due to the improvement of respiratoryrelated parameters [51].…”

Section: Rehabilitation Interventions To Improve Respiratory Functionmentioning

confidence: 98%

“…It could be applied in the form of inspiratory muscle training (IMT), expiratory muscle training (EMT), and their combination that has advantages like taking less time, not aggravating symptoms, and easy adaptation [40]. Short and long-term RMT provides positive improvements in respiratory muscle strength, spirometry parameters, cough efficiency, swallowing, fatigue, and dyspnea in pwMS [41][42][43][44][45]. Benefits from RMT are greater in pwMS whose disease severity was lower [46].…”

Section: Rehabilitation Interventions To Improve Respiratory Functionmentioning

confidence: 99%

“…The reason for the decrease in dyspnea is the slowing of respiratory rate and decline in carbon dioxide production due to the improvement of respiratoryrelated parameters [51]. The most practical point of low resistance IMT enhances the respiratory system without causing fatigue [45]. This is valuable in terms of compliance and adherence in RMT.…”

Section: Rehabilitation Interventions To Improve Respiratory Functionmentioning

confidence: 99%

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A Narrative Review of Respiratory Impairment, Assessment, and Rehabilitation in Multiple Sclerosis

Dereli

Kahraman

2022

Dubai Med J

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Background: Respiratory impairment is a problem seen in people with multiple sclerosis (pwMS) from the early stages of the disease but not frequently recognized by clinicians until the later stages. It is seen in different ways, such as respiratory muscle weakness, change in pulmonary volumes, and decrease in cough efficiency. This situation has consequences affecting individuals’ physical fitness, participation in daily life, and quality of life. Summary: This review explains possible respiratory impairment mechanisms, related problems, assessment, and rehabilitation approaches in pwMS. Key Messages: It is recommended a comprehensive assessment of respiratory functions in pwMS regardless of the disease severity and stage. In addition, pulmonary rehabilitation and other exercises can have positive effects on the respiratory functions of pwMS. In future studies, specific training parameters should be determined for pwMS to achieve optimal benefits. There is also a need for studies that apply respiratory muscle training in pwMS who have a high disease severity and limited participation in the activities of daily living.

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Section: Rehabilitation Interventions To Improve Respiratory Functionmentioning

confidence: 98%

Section: Rehabilitation Interventions To Improve Respiratory Functionmentioning

confidence: 99%

Section: Rehabilitation Interventions To Improve Respiratory Functionmentioning

confidence: 99%

See 1 more Smart Citation

A Narrative Review of Respiratory Impairment, Assessment, and Rehabilitation in Multiple Sclerosis

Dereli

Kahraman

2022

Dubai Med J

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“…This training model is implemented in guise of trained expiratory and inspiratory respiratory muscles, and a combination of them [313]. It has been proved that this type of rehabilitating training in MS patients is involving positive adaptations and improvements in respiratory muscle strength, spirometer parameters, cough efficiency, fatigue, and dyspnea [290,[314][315][316][317]. Besides, respiratory training improves the strength and endurance components of respiratory muscles and as a result promote lung functional capacity and performance [318].…”

Section: Pleiotropic Roles Of Physical Exercisementioning

confidence: 99%

Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise

et al. 2022

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Coronavirus disease-2019 (COVID-19) is associated with cytokine storm and is characterized by acute respiratory distress syndrome (ARDS) and pneumonia problems. The respiratory system is a place of inappropriate activation of the immune system in people with multiple sclerosis (MS), and this may cause damage to the lung and worsen both MS and infections.The concerns for patients with multiple sclerosis are because of an enhance risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MS patients pose challenges in this pandemic situation, because of the regulatory defect of autoreactivity of the immune system and neurological and respiratory tract symptoms. In this review, we first indicate respiratory issues associated with both diseases. Then, the main mechanisms inducing lung damages and also impairing the respiratory muscles in individuals with both diseases is discussed. At the end, the leading role of physical exercise on mitigating respiratory issues inducing mechanisms is meticulously evaluated.

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“…Among various types for respiratory muscle training programs, inspiratory muscle training (IMT) with the emphasis on strength and using a resistive threshold device has a moderate effect on improving inspiratory muscle strength in persons with MS. 5,[7][8][9][10] Compared to breathing and maximum exhalation exercises, 12-week IMT resulted in a significantly greater improvement in inspiratory muscle pressure and dyspnea in ambulatory and non-ambulatory persons with MS. 10 A recent study confirmed the benefits of IMT without adverse effects in non-ambulatory persons with advanced MS (PwAMS), defined as the Expanded Disability Status Scale (EDSS) ≥6.5. 11 Despite the research evidence, IMT has not been routinely integrated into the rehabilitation management in PwMS.…”

Section: Introductionmentioning

confidence: 99%

Predictors of positive outcomes following resistive inspiratory muscle training in non-ambulatory persons with advanced multiple sclerosis

Huang

Doyle

Burnham

et al. 2022

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Background Inspiratory muscle training (IMT) using a threshold device improves inspiratory muscle strength. What factors influence the IMT outcome has not been examined. Objective To identify predictors of the positive outcome following IMT in persons with advanced multiple sclerosis (PwAMS). Methods Inclusion criteria were non-ambulatory PwAMS, Expanded Disability Status Scale (EDSS) ≥6.5, age >18 years, no acute medical conditions, current non-smokers, and ability to consent. Participants ( n = 38) performed daily inspiratory exercises using a resistive threshold device for 10 weeks. Baseline measurements included age, sex, body mass index, year post multiple sclerosis diagnosis, comorbidities, EDSS, Modified Fatigue Impact Scale-5, and oral Symbol Digit Modality Test. The percentage of completed prescribed exercise trials (Trials%) during the 10-week intervention was calculated. Age- and sex-adjusted predicted values of maximum inspiratory pressure (MIP%pred) and maximum expiratory pressure (MEP%pred) were obtained before and after the 10-week intervention. Backward multivariable regression analyses for the primary outcome (MIP%pred) were conducted. Results After controlling for the initial MIP%pred, perceived fatigue at the baseline and Trial% were significant and independent predictors of MIP%pred after IMT. Conclusion Less fatigue at the baseline and higher adherence to the prescribed exercise repetitions were positive predictors of the positive outcome following IMT in PwAMS.

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Effects of 12-week inspiratory muscle training with low resistance in patients with multiple sclerosis: A non-randomised, double-blind, controlled trial

Cited by 9 publications

References 29 publications

A Narrative Review of Respiratory Impairment, Assessment, and Rehabilitation in Multiple Sclerosis

A Narrative Review of Respiratory Impairment, Assessment, and Rehabilitation in Multiple Sclerosis

Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise

Predictors of positive outcomes following resistive inspiratory muscle training in non-ambulatory persons with advanced multiple sclerosis

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