EFFECTS OF 17α-Hydroxy-6α-Methylprogesterone ACETATE (DEPO-PROVERA) ON URINARY GONADOTROPHINS AND OESTROGENS IN MAN

Abstract

Weekly injections of 17α-hydroxy-6α-methylprogesterone acetate to three patients with gonadal dysgenesis exhibiting high urinary gonadotrophins and one girl with marked enlargement of breasts and high urinary oestrogens, led to suppression of both urinary gonadotrophins and oestrogens in two patients and of oestrogens alone in the third case. There was no significant effect on the urinary 17-ketosteroids or 17-hydroxycorticosteroids.

Effects of Long-term Use of Depo-medroxyprogesterone Acetate on Lipid Metabolism in Nepalese Women

“…injection every 3 months. The contraceptive appears to be a potent inhibitor of gonadotrophins [2, 3]. …”

Testosterone and Its Analogs as a Male Contraceptive

“…have been used for therapeutic approaches in sexual disorders such as hypogonadism and development of contraceptive dose, etc. [3,4,[12][13][14][15].…”

“…DMPA is administered as a single 150 mg intramuscular (i.m.) injection every 3 months and appears to be a potent inhibitor of gonadotropins [15]. The spermatogenesis was rapidly and completely suppressed after the administration of 500 mg TU in tea seed oil every 6 weeks in combination with 250 mg DMPA every 12 weeks in Indonesian men [37].…”

Antifertility Agents

“…Antigonadotropic agents were unsuccessfully employed (83), as were antispermatogenic compounds (84), despite early encouraging reports (85,86). The use of a long-acting progestogen in the male has been suggested (87). Despite theoretically useful approaches to fertility control with antibodies, comprehensive reviews have failed to indicate any practical development of the long-sought contraceptive vaccine, although this area is being increasingly explored by A. Tyler and others (88,89).…”