Effects of 17β-hydroxy-7α-methylandrost-5-en-3-one (RMI 12,936) on pregnant rabbits

Saksena, S.K.; Lau, I.F.; Chang, M. C.

doi:10.1016/s0010-7824(79)80039-6

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…RMI 12,936 (17ß-hydroxy-7a-methyl-androst-5-en-3-one) has been reported to possess antifertility activity when administered at any time during gestation in rats (Kendle, 1975(Kendle, , 1976(Kendle, , 1978Saksena, Salmonsen & Lau, 1979b), hamsters (Lau & Saksena, 1979) and rabbits (Saksena, Lau & Chang, 1979a). In the rat, the compound caused an acceleration of egg transport and termination of pregnancy (Kendle, 1975), and was associated with a reduction in serum progesterone concentrations (Kendle, 1976) although no such reduction was found by Saksena et al (1979b), who used a slightly different treatment schedule.…”

Section: Introductionmentioning

confidence: 99%

Effect of RMI 12,936 on early pregnancy in mice

Parthasarathy¹,

Munshi²

1981

Reproduction

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Treatment with RMI 12,936 blocked the mitotic shift from epithelial to stromal cells normally observed in the uterus on Day 4 of pregnancy, and inhibited implantation. While progesterone alone could reverse the change in pattern of cell division in the preparation of the uterus for implantation, both oestradiol and progesterone were necessary to induce implantation and maintain pregnancy. A reduction in the activity of delta 5-3 beta-hydroxysteroid dehydrogenase in the ovaries of RMI 12,936-treated mice suggests that the compound affects luteal synthesis of oestrogen and progesterone in mice.

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