Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproduction and oogenesis in zebrafish (Brachydanio rerio)

Wannemacher, Robert W.; Rebstock, Anne‐Sophie; Kulzer, Erwin; Schrenk, Dieter; Bock, Karl Walter

doi:10.1016/0045-6535(92)90059-z

Cited by 62 publications

(29 citation statements)

References 23 publications

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“…Moreover, a decrease in fecundity was also previously observed in DDT-intoxicated brook trout (Salvelinus fontinalis) (Macek, 1968) and on zebrafish intoxicated with 2,3,7,8-TCDD (Wannemacher et al, 1992).…”

Section: Fertility and Reproductive Successsupporting

confidence: 56%

Effects of Polychlorinated Biphenyls on Liver Ultrastructure, Hepatic Monooxygenases, and Reproductive Success in the Barbel

Hugla

Thomé

1999

Ecotoxicology and Environmental Safety

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Section: Fertility and Reproductive Successsupporting

confidence: 56%

Effects of Polychlorinated Biphenyls on Liver Ultrastructure, Hepatic Monooxygenases, and Reproductive Success in the Barbel

Hugla

Thomé

1999

Ecotoxicology and Environmental Safety

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“…These deformities closely resemble the “blue sac syndrome” that has been described in several fish species, including rainbow trout ( Oncorhynchus mykiss ), zebrafish ( Danio rerio ), medaka ( Oryzias latipes ), and killifish ( Fundulus heteroclitus ), exposed to certain halogenated aromatic compounds that are agonists for the aryl hydrocarbon receptor (AHR) (Chen and Cooper 1999; Elonen et al 1998; Helder 1981; Toomey et al 2001; Walker and Peterson 1991; Wannemacher et al 1992). These compounds include coplanar polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD), collectively referred to here as planar halogenated aromatic hydrocarbons (pHAHs).…”

mentioning

confidence: 65%

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors inFundulus heteroclitus

Wassenberg¹,

Giulio²

2004

Environ Health Perspect

188

175

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Widespread contamination of aquatic systems with polycyclic aromatic hydrocarbons (PAHs) has led to concern about effects of PAHs on aquatic life. Some PAHs have been shown to cause deformities in early life stages of fish that resemble those elicited by planar halogenated aromatic hydrocarbons (pHAHs) that are agonists for the aryl hydrocarbon receptor (AHR). Previous studies have suggested that activity of cytochrome P4501A, a member of the AHR gene battery, is important to the toxicity of pHAHs, and inhibition of CYP1A can reduce the early-life-stage toxicity of pHAHs. In light of the effects of CYP1A inhibition on pHAH-derived toxicity, we explored the impact of both model and environmentally relevant CYP1A inhibitors on PAH-derived embryotoxicity. We exposed Fundulus heteroclitus embryos to two PAH-type AHR agonists, β-naphthoflavone and benzo(a)pyrene, and one pHAH-type AHR agonist, 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126), alone and in combination with several CYP1A inhibitors. In agreement with previous studies, coexposure of embryos to PCB-126 with the AHR antagonist and CYP1A inhibitor α-naphthoflavone decreased frequency and severity of deformities compared with embryos exposed to PCB-126 alone. In contrast, embryos coexposed to the PAHs with each of the CYP1A inhibitors tested were deformed with increased severity and frequency compared with embryos dosed with PAH alone. The mechanism by which inhibition of CYP1A increased embryotoxicity of the PAHs tested is not understood, but these results may be helpful in elucidating mechanisms by which PAHs are embryotoxic. Additionally, these results call into question additive models of PAH embryotoxicity for environmental PAH mixtures that contain both AHR agonists and CYP1A inhibitors.

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“…Henry et al (1997) were the first to characterize TCDD developmental toxicity in larval zebrafish, and Elonen et al (1998) reported similar findings. Reproductive toxicity of TCDD is also similar in adult zebrafish compared with other fish species (King-Heiden et al, 2005, 2006, 2009; Wannemacher et al, 1992). Due to the extensive genetic characterization and rigorous examination of embryonic and larval development in zebrafish, this model is ideal for investigating the cellular and molecular basis of TCDD developmental and reproductive toxicity.…”

Section: Zebrafish As a Model For Assessing Tcdd Reproductive And Devmentioning

confidence: 78%

“…Most research on TCDD reproductive toxicity in zebrafish has evaluated effects on female reproduction and demonstrated that ovarian development and egg release is impaired. In adults, dietary exposure to acutely toxic levels of TCDD induce overt toxicity associated with dose-dependent reductions in egg production and a complete suppression of spawning activity, corresponding with arrested gonad development and oocyte atresia (Wannemacher et al, 1992). Exposure to sublethal concentrations of TCDD also impairs female reproduction.…”

Section: Using Zebrafish To Understand Tcdd-induced Reproductive Toximentioning

confidence: 99%

Reproductive and developmental toxicity of dioxin in fish

King‐Heiden

Mehta

Xiong

et al. 2012

Molecular and Cellular Endocrinology

146

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin) is a global environmental contaminant and the prototypical ligand for investigating aryl hydrocarbon receptor (AHR)-mediated toxicity. Environmental exposure to TCDD results in developmental and reproductive toxicity in fish, birds and mammals. To resolve the ecotoxicological relevance and human health risks posed by exposure to dioxin-like AHR agonists, a vertebrate model is needed that allows for toxicity studies at various levels of biological organization, assesses adverse reproductive and developmental effects and establishes appropriate integrative correlations between different levels of effects. Here we describe the reproductive and developmental toxicity of TCDD in feral fish species and summarize how using the zebrafish model to investigate TCDD toxicity has enabled us to characterize the AHR signaling in fish and to better understand how dioxin-like chemicals induce toxicity. We propose that such studies can be used to predict the risks that AHR ligands pose to feral fish populations and provide a platform for integrating risk assessments for both ecologically relevant organisms and humans.

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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproduction and oogenesis in zebrafish (Brachydanio rerio)

Cited by 62 publications

References 23 publications

Effects of Polychlorinated Biphenyls on Liver Ultrastructure, Hepatic Monooxygenases, and Reproductive Success in the Barbel

Effects of Polychlorinated Biphenyls on Liver Ultrastructure, Hepatic Monooxygenases, and Reproductive Success in the Barbel

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors inFundulus heteroclitus

Reproductive and developmental toxicity of dioxin in fish

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