Introduction: Heat cured acrylic resin is one of the most widely used denture bases. Patients need to keep the removable denture clean so they don’t adversely affect the patients. Natural ingredients such as soursop leaves (Anonna muricata L.) are known with its benefits so they can be used as a denture cleanser. This research aimed to study the transversal strength of heat cured acrylic resin in immersion of extract Anonna muricata L. effervescent with various concentrations (25%, 35% and 45%). Methods: 24 samples of heat cured acrylic with size of 65mm x 10mm x 2,5mm randomly divided in 4 groups. The control group, the 25%, the 35%, and the 45% immersed in 15 minutes 3 time a day for 10 days. The transversal strength measured by Universal Machine Test (Shimadzu) and analyzed by Kruskal-Wallis. Results: The average transversal strength of the control group showed 118,59 MPa, 25% group showed 114.35 MPa, 35% group showed 117.28 MPa, and 45% showed 111,32 MPa. Based on Kruskal-Wallis, there are no significant differences with a significant value p>0,05 (p=0,886). Conclusion: The highest tranversal strength was found in control group whilst the lowest transversal strength found in group of 45% concentrations. Immersion of heat cured acrylic resin in 25%, 35% and 45% concentration of extract Anonna muricata L. effervescent did not affect the transversal strength of the material.