Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion

Zoeller, Robert F.; Stout, Jeffrey R.; OʼKroy, J. A.; Torok, D. J.; Mielke, Michelle M.

doi:10.1007/s00726-006-0399-6

Cited by 79 publications

(106 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We also did not find any relationship 22 between the magnitude of increase in muscle carnosine concentration and the change in time--trial 23 performance. To our knowledge, this study is the first to document the lack of effect of beta--24 supplementation on an actual endurance exercise performance test as previous studies utilised 1 incremental exercise tests (Stout et al, 2007;Zoeller et al, 2007) and high--intensity efforts at the 2 end of a prolonged cycling protocol (Van Thienen et al, 2009). 3 A key finding in this study is the largest ever--reported relative increase in muscle carnosine 4 concentration following beta--alanine supplementation.…”

Section: Discussion 18mentioning

confidence: 53%

Doubling of Muscle Carnosine Concentration Does Not Improve Laboratory 1-Hr Cycling Time-Trial Performance

Chung¹,

Baguet²,

Bex³

et al. 2014

International Journal of Sport Nutrition and Exercise Metabolism

View full text Add to dashboard Cite

1Muscle carnosine loading through chronic oral beta--alanine supplementation has been shown to be 2 effective for short--duration, high--intensity exercise. This randomised, placebo controlled study 3 explored whether the ergogenic effect of beta--alanine supplementation is also present for longer 4 duration exercise. Subjects (27 well--trained cyclists/triathletes) were supplemented with either 5 beta--alanine or placebo (6.4 g/day) for six weeks. Time to completion and physiological variables for 6 a 1--h cycling time--trial were compared between pre--and post--supplementation. Muscle carnosine 7 concentration was also assessed via proton magnetic resonance spectroscopy before and after 8 supplementation. Following beta--alanine supplementation, muscle carnosine concentration was 9 increased by 143 ± 151% (mean ± SD; p < 0.001) in the gastrocnemius and 161 ± 56% (p < 0.001) in 10 the soleus. Post--supplementation time trial performance was significantly slower in the placebo 11 group (60.6 ± 4.4 to 63.0 ± 5.4 min; p < 0.01) and trended towards a slower performance following 12 beta--alanine supplementation (59.8 ± 2.8 to 61.7 ± 3.0 min; p = 0.069). We found an increase in 13 lactate/proton concentration ratio following beta--alanine supplementation during the time--trial 14 (209.0 ± 44.0 (beta--alanine) vs. 161.9 ± 54.4 (placebo); p < 0.05), indicating that a similar lactate 15 concentration was accompanied by a lower degree of systemic acidosis, even though this acidosis 16 was quite moderate (pH ranging from 7.30--7.40). In conclusion, chronic beta--alanine 17 supplementation in well--trained cyclists had a very pronounced effect on muscle carnosine 18 concentration and a moderate attenuating effect on the acidosis associated with lactate 19accumulation, yet without affecting 1--h time--trial performance under laboratory conditions. 20

show abstract

Section: Discussion 18mentioning

confidence: 53%

Doubling of Muscle Carnosine Concentration Does Not Improve Laboratory 1-Hr Cycling Time-Trial Performance

Chung¹,

Baguet²,

Bex³

et al. 2014

International Journal of Sport Nutrition and Exercise Metabolism

View full text Add to dashboard Cite

show abstract

“…It is important to emphasize that most investigations involving BA supplementation have enrolled physically active individuals, rather than well-trained athletes (Hill et al 2007;Stout et al 2007;Zoeller et al 2007;Smith et al 2009). Despite the methodologic constraints inherent in studies involving athletes (e.g., reduced sample size, competition schedule constraints, inability to perform invasive assessments), they are important to substantiate the efficacy of nutritional aids in sports.…”

Section: Discussionmentioning

confidence: 99%

The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance

Painelli

Roschel

Jesus

et al. 2013

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

We investigated the effect of beta-alanine (BA) alone (study A) and in combination with sodium bicarbonate (SB) (study B) on 100- and 200-m swimming performance. In study A, 16 swimmers were assigned to receive either BA (3.2 g·day−1 for 1 week and 6.4 g·day−1 for 4 weeks) or placebo (PL; dextrose). At baseline and after 5 weeks of supplementation, 100- and 200-m races were completed. In study B, 14 were assigned to receive either BA (3.2 g·day−1 for 1 week and 6.4 g·day−1 for 3 weeks) or PL. Time trials were performed once before and twice after supplementation (with PL and SB), in a crossover fashion, providing 4 conditions: PL-PL, PL-SB, BA-PL, and BA-SB. In study A, BA supplementation improved 100- and 200-m time-trial performance by 2.1% (p = 0.029) and 2.0% (p = 0.0008), respectively. In study B, 200-m time-trial performance improved in all conditions, compared with presupplementation, except the PL-PL condition (PL-SB, +2.3%; BA-PL, +1.5%; BA-SB, +2.13% (p < 0.05)). BA-SB was not different from BA-PL (p = 0.21), but the probability of a positive effect was 78.5%. In the 100-m time-trial, only a within-group effect for SB was observed in the PL-SB (p = 0.022) and BA-SB (p = 0.051) conditions. However, 6 of 7 athletes swam faster after BA supplementation. The probability of BA having a positive effect was 65.2%; when SB was added to BA, the probability was 71.8%. BA and SB supplementation improved 100- and 200-m swimming performance. The coingestion of BA and SB induced a further nonsignificant improvement in performance.

show abstract

“…The effect of exercise performance improvement by L-ornithine hydrochloride ingestion may not be expected in the case of the present relatively brief, high-intensity exercise. Many previous studies have reported the effects of amino acid ingestion on improving performance, but a variety of exercise types were used (de Araujo et al, 2006;Norton and Layman, 2006;Zoeller et al, 2007;Smith et al, 2008). Namely, there are studies which used short duration, high-intensity exercise and studies which used long term, moderate-intensity exercise.…”

Section: Discussionmentioning

confidence: 99%

The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise

et al. 2010

View full text Add to dashboard Cite

Objectives: L-ornithine has an important role in ammonia metabolism via the urea cycle. This study aimed to examine the effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise. Subjects/Methods: In all, 14 healthy young adults (age: 22.2 ± 1.0 years, height: 173.5 ± 4.6 cm, body mass: 72.5 ± 12.5 kg) who trained regularly conducted incremental exhaustive ergometer bicycle exercises after L-ornithine hydrochloride supplementation (0.1 g/kg, body mass) and placebo conditions with a cross-over design. The exercise time (sec) of the incremental ergometer exercise, exercise intensity at exhaustion (watt), maximal oxygen uptake (ml per kg per min), maximal heart rate (beats per min) and the following serum parameters were measured before ingestion, 1 h after ingestion, just after exhaustion and 15 min after exhaustion: ornithine, ammonia, urea, lactic acid and glutamate. All indices on maximal aerobic capacity showed insignificant differences between both the conditions. Results: Plasma ammonia concentrations just after exhaustion and at 15 min after exhaustion were significantly more with ornithine ingestion than with placebo. Plasma glutamate concentrations were significantly higher after exhaustion with ornithine ingestion than with placebo. Conclusions: It was suggested that, although the ingestion of L-ornithine hydrochloride before the exercise cannot be expected to improve performance, it does increase the ability to buffer ammonia, both during and after exercise.

show abstract

Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion

Cited by 79 publications

References 20 publications

Doubling of Muscle Carnosine Concentration Does Not Improve Laboratory 1-Hr Cycling Time-Trial Performance

Doubling of Muscle Carnosine Concentration Does Not Improve Laboratory 1-Hr Cycling Time-Trial Performance

The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance

The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise

Contact Info

Product

Resources

About