Effects of 28 days silicon dioxide aerosol exposure on respiratory parameters, blood biochemical variables and lung histopathology in rats

Deb, Utsab; Lomash, Vinay; Raghuvanshi, Suchita; Pant, S. C.; Vijayaraghavan, R.

doi:10.1016/j.etap.2012.07.009

Cited by 8 publications

(7 citation statements)

References 20 publications

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“…Cement factory workers are also exposed to a mixture of components, including Ca, Si, and Al, which have been linked to respiratory function deficits [ 49 ]. Silicon dioxide, an ubiquitous substance in cement factories, can be inhaled and become embedded deep into the alveolar sacs to start an inflammatory reaction releasing chemokine [ 50 ]. Such persistent chronic irritation caused by cement could induce inflammatory responses, which have been repeatedly associated with reduced lung function [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study

et al. 2014

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BackgroundExposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to respiratory effects remains under-investigated. We evaluated the effects of traffic-related PM2.5 and its elemental components on lung function in two highly exposed groups of healthy adults in Beijing, China.MethodsThe Beijing Truck Driver Air Pollution Study (BTDAS) included 60 truck drivers and 60 office workers evaluated in 2008. On two days separated by 1-2 weeks, we measured lung function at the end of the work day, personal PM2.5, and nine elemental components of PM2.5 during eight hours of work, i.e., elemental carbon (EC), potassium (K), sulfur (S), iron (Fe), silicon (Si), aluminum (Al), zinc (Zn), calcium (Ca), and titanium (Ti). We used covariate-adjusted mixed-effects models including PM2.5 as a covariate to estimate the percentage change in lung function associated with an inter-quartile range (IQR) exposure increase.ResultsThe two groups had high and overlapping exposure distributions with mean personal PM2.5 of 94.6 μg/m3 (IQR: 48.5-126.6) in office workers and 126.8 μg/m3 (IQR: 73.9-160.5) in truck drivers. The distributions of the nine elements showed group-specific profiles and generally higher levels in truck drivers. In all subjects combined, forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) did not significantly correlate with PM2.5. However, FEV1 showed negative associations with concentrations of four elements: Si (-3.07%, 95% CI: -5.00; -1.11, IQR: 1.54), Al (-2.88%, 95% CI: -4.91; -0.81, IQR: 0.86), Ca (-1.86%, 95% CI: -2.95; -0.76, IQR: 1.33), and Ti (-2.58%, 95% CI: -4.44; -0.68, IQR: 0.03), and FVC showed negative associations with concentrations of three elements: Si (-3.23%, 95% CI: -5.61; -0.79), Al (-3.26%, 95% CI: -5.73; -0.72), and Ca (-1.86%, 95% CI: -3.23; -0.47). In stratified analysis, Si, Al, Ca, and Ti showed associations with lung function only among truck drivers, and no significant association among office workers.ConclusionSelected elemental components of PM2.5 showed effects on lung function that were not found in analyses of particle levels alone.Electronic supplementary materialThe online version of this article (doi:10.1186/s12989-014-0051-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study

et al. 2014

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“…Administration of silica or asbestos to the lungs has also been shown to illicit persistent fibrosis like changes [18,[26][27][28]. However, as with FITC, there are histopathological features that are missing with respect to the histopathological features seen in patients with IPF.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Use of animal models in IPF research

Carrington

Jordan

Pitchford

et al. 2018

Pulmonary Pharmacology & Therapeutics

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Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with a poor prognosis and limited treatment options. Many compounds have shown efficacy in preclinical models of this condition, but only pirfenidone and nintedanib have been approved for clinical use. It is widely accepted that the current animal models of IPF need to be improved and in this review we have critically evaluated the current state of play of preclinical models of IPF and discuss the challenges facing this field. The popular model of a single intratracheal (I.T.) administration of bleomycin could be adapted to provide a more progressive fibrosis as is thought to occur in humans. Furthermore, currently the majority of new drugs are investigated in preclinical models of IPF are dosed using a prophylactic dosing regimen, whereas patients are almost always treated after the fibrosis is well established. Using a therapeutic dosing regimen in preclinical models would be a better way to establish potential efficacy of new drugs. The most popular endpoints examined in pre-clinical models of IPF are histological scoring and lung collagen content. However in IPF patients imaging and lung function tests are more commonly used as end points. We propose that examining more clinically relevant endpoints in pre-clinical models could also provide give a better indication of a compound's potential efficacy on endpoints measured in patients.

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“…Several human studies have reported decreased lung function (Al‐Neaimi et al, ; Meo et al, ; Mwaiselage et al, ; Zeleke et al, ; Nordby et al, ) and increased lung cancer risk (Koh et al, ; Rachiotis et al, ) in cement factory workers. Silicon dioxide (SiO 2 ), a ubiquitous substance, can be inhaled and get embedded deep into the alveolar sacs to start an inflammation reaction releasing chemokine (Deb et al, ). The persistent chronic irritation caused by cement could induce repeated cycles of cell death, cell proliferation, and other inflammatory responses, which may ultimately result in cancer (Rachiotis et al, ).…”

Section: Discussionmentioning

confidence: 99%

Altered methylation in tandem repeat element and elemental component levels in inhalable air particles

Hou

Zhang

Zheng

et al. 2013

Environ and Mol Mutagen

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Exposure to particulate matter (PM) has been associated with lung cancer risk in epidemiology investigations. Elemental components of PM have been suggested to have critical roles in PM toxicity, but the molecular mechanisms underlying their association with cancer risks remain poorly understood. DNA methylation has emerged as a promising biomarker for environmental-related diseases, including lung cancer. In this study, we evaluated the effects of PM elemental components on methylation of three tandem repeats in a highly-exposed population in Beijing, China. The Beijing Truck Driver Air Pollution Study was conducted shortly before the 2008 Beijing Olympic Games (June 15-July 27, 2008) and included 60 truck drivers and 60 office workers. On two days separated by 1-2 weeks, we measured blood DNA methylation of SATα, NBL2, D4Z4, and personal exposure to eight elemental components in PM2.5, including aluminum (Al), silicon (Si), sulfur (S), potassium (K), calcium (Ca) titanium (Ti), iron (Fe), and zinc (Zn). We estimated the associations of individual elemental component with each tandem repeat methylation in generalized estimating equations (GEE) models adjusted for PM2.5 mass and other covariates. Out of the eight examined elements, NBL2 methylation was positively associated with concentrations of Si (0.121, 95%CI: 0.030; 0.212, FDR=0.047) and Ca (0.065, 95%CI: 0.014; 0.115, FDR=0.047) in truck drivers. In office workers, SATα methylation was positively associated with concentrations of S (0.115, 95%CI: 0.034; 0.196, FDR=0.042). PM-associated differences in blood tandem-repeat methylation may help detect biological effects of the exposure and identify individuals who may eventually experience higher lung cancer risk.

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Effects of 28 days silicon dioxide aerosol exposure on respiratory parameters, blood biochemical variables and lung histopathology in rats

Cited by 8 publications

References 20 publications

Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study

Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study

Use of animal models in IPF research

Altered methylation in tandem repeat element and elemental component levels in inhalable air particles

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