Effects of 3-acetylpyridine on metabolism of nicotinic acid in rats

Guggenheim, K.; Diamant, E. J.

doi:10.1042/bj0690056

Cited by 6 publications

(2 citation statements)

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“…The inability of nicotinamide to overcome the toxic effect of 3-acetylpyridine in mosquito larvae was also similar to that of other higher organisms and insects. The toxic effect of 3-acetylpyridine could not be reversed by nicotinic acid in the dog and the rat (McDaniel et al 1955;Guggenheim & Diamant, 1958) but was reversible in mice and chick embryos (Woolley, 1952). The addition ofnicotinic acidto silkworms treated with 3-acetylpyridine reduced their mortality, but the weight of the recovered worms did not reach 30 % of that of the controls (Shyamala & Bhat, 1958).…”

Section: Discussionmentioning

confidence: 99%

“…The two-sided effect of 3-acetylpyridine, which acted both as a vitamin and an antivitamin for the dog and the rat, has been explained by the conversion of the analogue into nicotinic acid (McDaniel et at. 1955;Guggenheim & Diamant, 1958). When the dosage of 3-acetylpyridine exceeded the animal's capacity for detoxification, the excess of the analogue acted as an antagonist.…”

Section: Discussionmentioning

confidence: 99%

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Antimetabolites in the nutrition of Aedes aegypti L. larvae nicotinic acid analogues

Akov¹,

Guggenheim²

1963

Biochemical Journal

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Nicotinic acid antagonists have been employed in studies of insect nutrition (Shyamala & Bhat, 1958; Levinson & Bergmann, 1959), insect tissue cultures (Sanborn & Haskell, 1960), and insect development (Blaustein & Schneiderman, 1960). The effects obtained have usually been attributed to vitamin deficiencies. However, there is little direct evidence that antimetabolites affect insects in the same manner as they do higher animals. Few quantitative studies on the antivitamin-vitamin relationship, with insects as experimental animnals, are available. The purpose of the present study was to investigate the effect of five better-known nicotinic acid analogues on Aede8 aegypti L. larvae, grown on a chemically defined diet. The specificity of the nicotinic acid requirement of various organisms has been extensively studied. Dietary nicotinic acid can be replaced by tryptophan, many nicotinamide derivatives, and even some nicotinic acid analogues (Hundley, 1954). Small doses of 3-acetylpyridine had a vitamin-like activity for the dog and the rat (McDaniel, Hundley & Sebrell, 1955; Guggenheim & Diamant, 1958). The nicotinamide-3-acetylpyridine relationship was, therefore, studied in mosquito larvae, given a basic casein diet, on which the exact nicotinamide requirements were determined.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%