In order to explore the effect of cryogenic treatment on creep resistance of Cu-11.74Al-0.38Ni alloy at room temperature, the room temperature creep deformation of Cu-11.74Al-0.38Ni alloy before and after cryogenic treatment at different applied load and time were measured by nanoindention technique, and the products were also characterized by optical microscope. The results show that cryogenic treatment can refine the grains, and reduce creep deformation of the alloy, which can improve the creep resistant properties of Cu-11.74Al-0.38Ni alloy effectively.