Effects of 4-phenylbutyric acid on the development of diabetic retinopathy in diabetic rats: regulation of endoplasmic reticulum stress-oxidative activation

Abdel-Ghaffar, Amany; El-Hossary, Ghada Ghanem; Mahmoud, Atef Mohamed Sayed; El-Shazly, Amany H.; Hassanin, Olfat A.; Saleh, Anisa; Mansour, Sahar; Metwally, Fatma Gouda; Hanafy, Laila K.; Karam, Sawsan H.; Darweesh, Neveen; Ata, Ahmed Mostafa

doi:10.1080/13813455.2021.1888302

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…ERINSX10, Waltham, Massachusetts, USA), and the results were used to calculate homeostasis model assessment-insulin resistance (HOMA-IR) according to Abdel-Ghaffar. 41…”

Section: Methodsmentioning

confidence: 99%

“…ERINSX10, Waltham, Massachusetts, USA), and the results were used to calculate homeostasis model assessment-insulin resistance (HOMA-IR) according to Abdel-Ghaffar. 41 Histopathological and immunohistochemistry (IHC) assessment. Adipose, liver, and kidney tissue samples were dissected and fixed in neutral buffered formalin for 72 hours.…”

Section: Validation Of Molecular and Biochemical Signatures On The T2...mentioning

confidence: 99%

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Rosavin improves insulin resistance and alleviates hepatic and kidney damage via modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals

Ali,

Al-Amodi,

Hamady

et al. 2024

RSC Med. Chem.

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“…ERINSX10, Waltham, Massachusetts, USA), and the results were used to calculate homeostasis model assessment-insulin resistance (HOMA-IR) according to Abdel-Ghaffar. 41…”

Section: Methodsmentioning

confidence: 99%

Section: Validation Of Molecular and Biochemical Signatures On The T2...mentioning

confidence: 99%

Rosavin improves insulin resistance and alleviates hepatic and kidney damage via modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals

Ali,

Al-Amodi,

Hamady

et al. 2024

RSC Med. Chem.

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show abstract

“…Administration of 4-PBA could decrease retinal neuron death in the outer nuclear layer and ganglion cell layer by attenuating ER stress in these cells in diabetic models. 253 Sulforaphane is widely discovered in cruciferous plants and is a strong antioxidant and activator of nrf2. 254 Sulforaphane inhibits ER stress via the AMPK pathway, and it can also reduce inflammation, apoptosis, and OS in retinal cells.…”

Section: Involvement Of Er Stress In Primary Open-angle Glaucomamentioning

confidence: 99%

Endoplasmic reticulum stress: molecular mechanism and therapeutic targets

Chen,

Shi,

et al. 2023

Sig Transduct Target Ther

158

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The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated degradation, protein chaperons, and autophagy. ER stress is activated when proteostasis is broken with an accumulation of misfolded and unfolded proteins in the ER. ER stress activates an adaptive unfolded protein response to restore proteostasis by initiating protein kinase R-like ER kinase, activating transcription factor 6, and inositol requiring enzyme 1. ER stress is multifaceted, and acts on aspects at the epigenetic level, including transcription and protein processing. Accumulated data indicates its key role in protein homeostasis and other diverse functions involved in various ocular diseases, such as glaucoma, diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, achromatopsia, cataracts, ocular tumors, ocular surface diseases, and myopia. This review summarizes the molecular mechanisms underlying the aforementioned ocular diseases from an ER stress perspective. Drugs (chemicals, neurotrophic factors, and nanoparticles), gene therapy, and stem cell therapy are used to treat ocular diseases by alleviating ER stress. We delineate the advancement of therapy targeting ER stress to provide new treatment strategies for ocular diseases.

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Evaluating the potential of tauroursodeoxycholic acid as add-on therapy in amelioration of streptozotocin-induced diabetic kidney disease

Sankrityayan

Shelke

Kale

et al. 2023

European Journal of Pharmacology

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Effects of 4-phenylbutyric acid on the development of diabetic retinopathy in diabetic rats: regulation of endoplasmic reticulum stress-oxidative activation

Cited by 4 publications

References 54 publications

Rosavin improves insulin resistance and alleviates hepatic and kidney damage via modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals

Rosavin improves insulin resistance and alleviates hepatic and kidney damage via modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals

Endoplasmic reticulum stress: molecular mechanism and therapeutic targets

Evaluating the potential of tauroursodeoxycholic acid as add-on therapy in amelioration of streptozotocin-induced diabetic kidney disease

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