Effects of 5-hydroxytryptamine, LSD and related compounds on electrical activities evokedin vitro in thin sections from the superior colliculus

Kawai, Nobufumi; Yamamoto, Chosaburo

doi:10.1016/0028-3908(69)90060-4

Cited by 50 publications

(14 citation statements)

References 15 publications

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“…Stimulation may also occur (Boakes, Bradley, Briggs & Dray, 1970), and this is most frequently seen in regions with a small tryptaminergic input , whereas inhibition is predominant at sites with a large supply of tryptaminergic fibres such as the lateral geniculate (Curtis & Davis, 1962) or the superior colliculi ). An inhibitory effect of 5-HT applied in vitro during superfusion of isolated 526 5-HIAA AND 5-HT IN SUPERIOR COLLICULI slices of guinea-pig colliculi was found by Kawai & Yamamoto (1969); they recorded the post-synaptic field potential elicited by electrical stimulation of the optic tract.…”

Section: Discussionmentioning

confidence: 99%

Increase by visual stimuli in turnover of 5‐hydroxytryptamine in the superior colliculi of the rabbit.

Fukui¹,

Vogt²

1976

The Journal of Physiology

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SUMMARY1. Irregular light flashes were played on to one eye of dark adapted rabbits for periods of 20-80 min. The concentration of 5-hydroxyindol-3-ylacetic acid (5-HIAA) and of 5-hydroxytryptamine (5-HT) were estimated in left and right superior colliculi, thalami and hippocampi.2. In rabbits exposed to such visual stimuli for 30-60 min, there was an increase in the 5-HIAA content of the colliculus contralateral to the stimulated retina which averaged 17 % (P = 0-02), but no rise was seen if the exposure was shortened to 20

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Section: Discussionmentioning

confidence: 99%

Increase by visual stimuli in turnover of 5‐hydroxytryptamine in the superior colliculi of the rabbit.

Fukui¹,

Vogt²

1976

The Journal of Physiology

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“…As noted in the section above, the refinement of the uncrossed retinocollicular projection is activity-dependent and can be disrupted by blockade of RGC activity in one or both eyes with TTX (Fawcett et al, 1984;O'Leary et al, 1986;Thompson and Holt, 1989) or by application of n-methyl-D-aspartic acid (NMDA) antagonists directly to the SC . Serotonin profoundly depresses the activity of visual SC neurons in the superficial laminae (Kawai and Yamamoto, 1969;Straschill and Perwein, 1971;Huang et al, 1993). This action occurs chiefly, but not exclusively, by inhibition of excitatory retinocollicular synaptic transmission (Mooney et al, 1994) and is most likely mediated by increased potassium conductance and/or decreased calcium influx at the axon terminals (Penington and Kelly, 1990).…”

Section: Putative Mechanisms Of 5-ht Influence On Axon Arborsmentioning

confidence: 99%

Neonatally elevated serotonin levels alter terminal arbors of individual retinal ganglion cells in superior colliculus of hamsters

Crnko-Hoppenjans¹,

Mooney²,

Rhoades³

2001

J of Comparative Neurology

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Previous studies from this laboratory showed that sprouting of serotoninergic (5-HT) axons in the hamster's superior colliculus (SC), induced by a single subcutaneous injection of 5,7-dihydroxytryptamine (5,7-DHT) at birth (postnatal day 0 [P-0]), resulted in an increased terminal distribution of the uncrossed retinocollicular projection that was not associated with any changes in the number or distribution of ipsilaterally projecting retinal ganglion cells. The present study was undertaken to determine what effect this manipulation had on the terminal arbors of such axons. Retinocollicular axons of normal and 5,7-DHT-treated animals were anterogradely labeled with small intraretinal injections of the lipophilic dye 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) on P-16. After tissue processing on P-19, single retinocollicular axon arbors were reconstructed by using confocal microscopy. Quantitative analysis indicated that arbors from 5,7-DHT-treated hamsters had significantly greater total fiber lengths, areas, and volumes than those from normal animals. There were no differences between axons from the two groups in number of branch points, distribution of relative branch lengths, and numbers of bouton-like swellings. These results support the hypothesis that increased SC concentrations of 5-HT alter development of the uncrossed retinocollicular pathway such that a greater territory is covered by individual terminal arbors but that the number of synaptic contacts per arbor remains constant. This may explain, at least in part, the abnormally widespread distribution of the aggregate ipsilateral projection.

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“…Since the net effect of 5-HT application in the superficial SC laminae is a reduction of neuronal responsivity, it is reasonable to suggest that inhibition of transmitter release and hyperpolarization of SC cells may dominate in the SGS. Limited data from the in vitro experiments of Kawai and Yamamoto (1969) suggest that the presynaptic effects of 5-HT may be most important in modulating collicular responsivity. They tested only a small number of cells, but showed that application of 5-HT to slices of guinea pig SC suppressed spiking of SC cells evoked by optic tract stimulation, but that it had no effect on either spontaneous or glutamate-evoked action potentials.…”

Section: Synaptic Organization Of the Serotoninergic Inputmentioning

confidence: 99%

“…Functional studies have demonstrated that 5-HT has profound effects on the excitability of most superficial layer SC neurons. In a very early in vitro study that tested only a small number of cells, Kawai and Yamamoto (1969) showed that application of 5-HT to slices of guinea pig SC suppressed spiking of SC cells evoked by optic tract stimulation. Straschill and Perwein (1971) have been reported recently for superficial layer SC neurons in hamster by Huang and Mooney (1991).…”

Section: Introductionmentioning

confidence: 99%

Synaptic organization of the serotoninergic input to the superficial gray layer of the hamster's superior colliculus

Arce¹,

Bennett‐Clarke²,

Mooney³

et al. 1992

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Immunocytochemistry with an antibody directed against a serotonin (5-HT)-bovine serum albumin (BSA) conjugate was combined with electron microscopy and serial section analysis to examine the synaptic organization of the serotoninergic projection to the stratum griseum superficiale (SGS) of the hamster's superior colliculus (SC). Most of the 5-HT-immunoreactive swellings in the hamster's SC did not make conventional synaptic contacts. Examination of 250 such swellings in single thin sections revealed only 11 synapses. Assessment of an additional 50 swellings followed through serial sections showed that only 6% (N = 3) of these varicosities made conventional synaptic contacts. All the synapses made by serotoninergic axons were with the dendrites of SC neurons. These results demonstrate that the inhibitory effects of 5-HT on SC neurons in hamster are mainly mediated by the nonsynaptic release of this indoleamine.

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Effects of 5-hydroxytryptamine, LSD and related compounds on electrical activities evokedin vitro in thin sections from the superior colliculus

Cited by 50 publications

References 15 publications

Increase by visual stimuli in turnover of 5‐hydroxytryptamine in the superior colliculi of the rabbit.

Increase by visual stimuli in turnover of 5‐hydroxytryptamine in the superior colliculi of the rabbit.

Neonatally elevated serotonin levels alter terminal arbors of individual retinal ganglion cells in superior colliculus of hamsters

Synaptic organization of the serotoninergic input to the superficial gray layer of the hamster's superior colliculus

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