“…H 2 has also been shown to stimulate mitochondrial respiration, Q-cycle [ 25 ], and oxidative ATP phosphorylation (OXOPHOS) rate [ 26 ]. Pre-exercise HRW intake or H 2 inhalation has been shown to have an antifatigue effect across different modes of exercise, including endurance [ 27 , 28 , 29 ], strength-endurance drills [ 30 ], cycling anaerobic power output [ 31 ], maximal isokinetic muscle strength [ 32 ], and during prolonged, intermittent sprints [ 33 ]. H 2 administration strategies varied across studies, e.g., in duration of pre-exercise administration (30 min [ 30 ], 8 h [ 32 ], 24 h [ 28 ], 7 days [ 29 , 31 ], 2 weeks [ 33 ], and 4 weeks [ 27 ]) and administration mode (HRW [ 27 , 28 , 30 , 31 , 32 , 33 ], H 2 inhalation [ 29 ]), which complicates the comparison of the study results.…”