Effects of 72-h of exercise abstinence on affect and body dissatisfaction in healthy female regular exercisers

Niven, Ailsa; Rendell, Emily; Chisholm, Lindsey

doi:10.1080/02640410802027378

Cited by 8 publications

(4 citation statements)

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“…As suggested by a study carried out in female rats, the loss of sensitivity to opioids under exercise conditions may actually be fully reversed when the animals do not have access to RWs anymore (Smith and Lyle, 2006). This potential anhedonic-like behaviour induced by a brief period of exercise deprivation (observed in our WT animals) has also been reported by healthy women (who exercise at least four times per week) during a 72 h exercise abstinence (Niven et al, 2008).…”

Section: Discussionmentioning

confidence: 56%

Treatment of depressive‐like behaviour in Huntington's disease mice by chronic sertraline and exercise

Renoir

Pang

Zajac

et al. 2012

British J Pharmacology

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BACKGROUND AND PURPOSEDepression is the most common psychiatric disorder in Huntington's disease (HD) patients. Women are more prone to develop depression and such susceptibility might be related to 5-hydroxytryptaminergic (serotonergic) dysregulation. EXPERIMENTAL APPROACHWe performed tests of depression-related behaviours on female R6/1 HD mice that had been chronically treated with sertraline or provided with running-wheels. Functional assessments of 5-HT1A and 5-HT2A receptors were performed by measuring behavioural and physiological responses following administration of specific agonists, in combination with analysis of hippocampal gene expression. Finally we assessed the effect of exercise on hippocampal cell proliferation. KEY RESULTSFemale HD mice recorded increased immobility time in the forced-swimming test, reduced saccharin preference and a hyperthermic response to stress compared with wild-type animals. These alterations were improved by chronic sertraline treatment. Wheel-running also resulted in similar improvements with the exception of saccharin preference but failed to correct the hippocampal cell proliferation deficits displayed by HD mice. The benefits of sertraline treatment and exercise involved altered 5-HT1A autoreceptor function, as demonstrated by modulation of the exaggerated 8-OH-DPAT-induced hypothermia exhibited by female HD mice. On the other hand, sertraline treatment was unable to restore the reduced 5-HT1A and 5-HT2 heteroceptor function observed in HD animals. CONCLUSIONS AND IMPLICATIONSWe report for the first time a crucial role for 5-HT1A autoreceptor function in mediating the sex-specific depressive-like phenotype of female R6/1 HD mice. Our data further support a differential effect of chronic sertraline treatment and exercise on hippocampal cell proliferation despite common behavioural benefits.Abbreviations 5-CT, 5-carboxamidotryptamine; 5-HTT, 5-HT transporter; AUC, area under curve; BDNF, brain-derived neurotrophic factor; BrdU, 5-bromo-2′-deoxyuridine; FST, forced-swimming test; GR, glucocorticoid receptor; HD, Huntington's disease; HPA, hypothalamic-pituitary-adrenal; RW, running-wheel; SH, standard-housed; SSRIs, selective 5-HT re-uptake inhibitors; TST, tail-suspension test; WT, wild-type BJP British Journal of Pharmacology DOI:10.1111DOI:10. /j.1476DOI:10. -5381.2011 British Journal of Pharmacology (2012) IntroductionHuntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of CAG repeats in exon 1 of the huntingtin gene (The Huntington's Disease Collaborative Research Group, 1993). Clinical diagnosis of HD is determined on the basis of motor symptoms; however, the pre-motor stages of the disease are commonly associated with psychiatric manifestations including depression (Paulsen et al., 2005;Duff et al., 2007;Julien et al., 2007;Marshall et al., 2007). Depression is one of the most prevalent causes of disability worldwide and is diagnosed in women more frequently than in men (Fava and Kendler, 2000;Kornstein e...

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Section: Discussionmentioning

confidence: 56%

Treatment of depressive‐like behaviour in Huntington's disease mice by chronic sertraline and exercise

Renoir

Pang

Zajac

et al. 2012

British J Pharmacology

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“…While a significant number of studies (n = 11) investigated these negative effects as potential withdrawal symptoms within an addiction framework, the remainder did not. Notable theoretical perspectives included interpreting these effects in light of potential biological determinants (e.g., Antunes et al, 2016;Glass et al, 2004;Kop et al, 2008;Poole et al, 2011;Weinstein et al, 2007;Zeller et al, 2011), or as negative non-addiction-related health outcomes resulting from not exercising (Ablin et al, 2013;Berlin et al, 2006;Niven et al, 2008). Across all behaviors examined in the present review, only negative abstinence effects from exercise have been interpreted from a biological perspective.…”

Section: Sr(all)mentioning

confidence: 99%

Short-term abstinence effects across potential behavioral addictions: A systematic review

Fernandez

Kuss

Griffiths

2020

Clinical Psychology Review

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“…In a study of longer‐term impacts, Guszkowska and Sionek () showed a significant stable change in mood profile as a result of a 12‐week‐long aerobic training program. Niven, Rendell, and Chisholm () showed that a 72‐hr exercise abstinence period resulted in mood deterioration and body dissatisfaction in regularly active women.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Effects of 45‐minute Aerobic Training and Cognitive Task Solving on Transient Mood States in a Female Student Sample

Stolarska

Stolarski

Matthews

2019

Applied Psych Health & Well

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Background: The beneficial effects of moderate-intensity physical exercise on mood are well established. Students in higher education are a group vulnerable to stress who may benefit from aerobic exercise classes. The present study broadens existing findings by testing the impact on mood of a 45-minute-long aerobic training session, conducted in a naturalistic setting. Method: A three-dimensional mood assessment that distinguished hedonic tone (pleasantness of mood) from energetic and tense arousal dimensions was used for assessment of pre-and posttraining mood in a sample of women (n = 120) taking part in a 45-minute aerobic training. A control group (n = 120) performed cognitive tasks. Results: Physical but not cognitive activity elevated mood on all three dimensions, but the effect size was largest for energetic arousal. It was also found that mood improvements in terms of energy and tension change were strongest for individuals initially low in hedonic tone. Conclusions: The finding supports the hypothesis that successful completion of an exercise session in a naturalistic setting may enhance mood in female students. At a practical level, the study suggests that exercise classes may help students cope with the mood impairments resulting from demanding cognitive activities, leading to potential educational benefits.

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Effects of 72-h of exercise abstinence on affect and body dissatisfaction in healthy female regular exercisers

Cited by 8 publications

References 22 publications

Treatment of depressive‐like behaviour in Huntington's disease mice by chronic sertraline and exercise

Treatment of depressive‐like behaviour in Huntington's disease mice by chronic sertraline and exercise

Short-term abstinence effects across potential behavioral addictions: A systematic review

A Comparison of the Effects of 45‐minute Aerobic Training and Cognitive Task Solving on Transient Mood States in a Female Student Sample

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