Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study

Anton, Stephen D.; Ebner, Natalie C.; Dzierzewski, Joseph M.; Zlatar, Zvinka Z.; Gurka, Matthew J.; Dotson, Vonetta M.; Kirton, Joshua W.; Mankowski, Robert T.; Marsiske, Michael; Manini, Todd M.

doi:10.1089/acm.2017.0398

Cited by 45 publications

(80 citation statements)

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“…Fifteen studies [26][27][28][29][30][31][35][36][37][40][41][42][43][44][45] met the inclusion criteria and were included in the current systematic review. The studies examined the effects of (poly)phenol-rich supplementation intake on cognitive functions and/or brain-related parameters (e.g., neuroimaging, neuroplasticity, CBF, etc).…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of each study as well as the cognitive and the neurological changes following rich-(poly)phenol supplementation compared to placebo supplementation are summarized in Tables 2 and 3, respectively. Eight papers [26,27,35,36,40,41,43,44] examined only the effect of rich-(poly)phenol supplementation on different cognitive functions such as visual attention, working memory, reaction time, executive functioning, and learning abilities. Five studies [28,29,31,37,42] examined the effect of rich-(poly)phenol supplementation on cognitive function as well as a variety of brain-related parameters such as brain perfusion, cerebral blood flow, cerebral hemodynamics, hippocampal functional connectivity, neuroplasticity, neuroinflammation, and other brain-related parameters.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Two studies [30,45] only examined the change in cerebral blood flow parameters following rich-(poly)phenol supplementation without cognitive function measurements. Concerning the acute (up to 2 h) and chronic effects of (poly)phenol-rich supplementation on the abovementioned functions, twelve studies investigated the chronic effect [26,27,29,31,35,36,[40][41][42][43][44][45], two studies investigated only the acute effect [30,37], and only one study [28] investigated both acute and chronic effect of (poly)phenol-rich supplementation on cognitive and brain functions.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Eight studies employed two parallel experimental arms, with seven of them using placebo and rich-(poly)phenol supplementation as treatment arms [29,31,35,[41][42][43][44], while the remaining study [45] used poorand rich-(poly)phenol supplementation as treatment arms. Two studies employed three parallel experimental arms with one study using placebo as the control arm and low and high (poly)phenol doses as treatment arms [40] and the second using only (poly)phenol supplementation at different doses (i.e., low, moderate, and high) [26]. Two studies used four parallel experimental arms with one arm being the placebo and three arms for the different doses of (poly)phenol supplementation [27,28].…”

Section: Study Design and Supplement Administrationmentioning

confidence: 99%

“…The fifteen trials included in this review employed different varieties of dietary (poly)phenol supplementation with an intervention period that ranged from acute (up to 2 h) to multiple weeks/months (i.e., 2 weeks to 6 months). Three studies [29,40,42] opted for resveratrol extract treatment with a dose ranging from 200-300 mg/day (low-moderate dose) to 1000 mg/day (high dose). Three studies [35,36,43] opted for isoflavones extract treatment with a dose ranging from 55 mg/day to 110 mg/day (high dose).…”

Section: Study Design and Supplement Administrationmentioning

confidence: 99%

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The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

Ammar

Trabelsi

Müller

et al. 2020

JCM

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Context: As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest. Objective: This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in aging adults. Data Sources: PubMed and Web of Science databases were searched for relevant randomized placebo-controlled trials (RCTs) published from inception to July 2019. Study Selection: Two researchers independently screened 4303 records, using the PICOS criteria: Participants were aging adults; Intervention was based on acute and/or chronic (poly)phenols-rich supplementation; Comparator was any comparator; Outcomes included cognitive function and neuroprotective measures; and Study design was RCTs. A third researcher was consulted when discrepancies arose. Fifteen high-quality (mean PEDro score = 8.8 ± 0.56) RCTs (total participants: 918 healthy older adults) were included in the final sample. Data Extraction: Information on study design, employed treatment, characteristics of participants, outcomes, and the correspondent assessing methods were extracted. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Data Analysis and Results: A random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. Pooled results yielded a trivial ES (−0.2 to 0.03) for brain-derived neurotrophic factor and neuroinflammatory parameters and small (0.36) to moderate (0.82) ES for executive functions. Conclusion: This meta-analysis failed to provide evidence regarding the neuroprotective and anti-inflammatory effect of (poly)phenols supplementation in aging adults. However, findings from individual studies, included in this systematic review, suggest polyphenol-rich supplementation may improve some cognitive and brain functions in older adults. The beneficial effect of polyphenols seems to depend on ingested dose and bioavailability. Results suggest at least an intermediate dose (≥500 mg), and intermediate (≈9%) to high (43%) bioavailability rates are needed to cross the brain blood barrier and to exert a significant effect on cognitive health.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Design and Supplement Administrationmentioning

confidence: 99%

Section: Study Design and Supplement Administrationmentioning

confidence: 99%

See 3 more Smart Citations

The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

Ammar

Trabelsi

Müller

et al. 2020

JCM

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Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review

Yadegar,

Mohammadi,

Yadegar

et al. 2024

Phytotherapy Research

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Resveratrol (RSV) has garnered significant attention in recent years due to its potential benefits against chronic diseases. However, its effects and safety in older adults have not been comprehensively studied. This study aimed to determine the effects and safety of RSV supplementation in older adults. MEDLINE/PubMed, Scopus, and Web of Science databases were comprehensively searched for eligible studies. Studies were enrolled if they were randomized clinical trials and had incorporated RSV supplementation for older adults. Two independent authors conducted the literature search, and eligibility was determined according to the PICOS framework. Study details, intervention specifics, and relevant outcomes were collected during the data collection. The Cochrane RoB‐2 tool was used to evaluate the risk of bias. This review included 10 studies. The combination of RSV and exercise improved exercise adaptation and muscle function in healthy older adults and physical performance and mobility measures in individuals with functional limitations. RSV showed potential neuroprotective effects in patients with Alzheimer's disease. In overweight individuals, RSV demonstrated a positive impact on cognitive function, but it increased some biomarkers of cardiovascular disease risk at high doses. In older adults with diabetes and those with peripheral artery disease (PAD), RSV was not more effective than placebo. No study reported significant adverse events following RSV treatment. RSV can improve various health parameters in age‐related health conditions. However, the optimal dosage, long‐term effects, and potential interactions with medications still need to be investigated through well‐designed RCTs.

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Alzheimer’s disease: natural products as inhibitors of neuroinflammation

Olajide

Sarker

2020

Inflammopharmacol

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Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD.

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Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study

Cited by 45 publications

References 46 publications

The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review

Alzheimer’s disease: natural products as inhibitors of neuroinflammation

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