Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study

Abstract

CIHE program was as effective as IIHE program in increasing the level of PA, and the increase in PA resulted in significant change in HOMA-IR, IGF-1 axis, TNF-α, and adiponectin levels in stage II-III colorectal cancer survivors.

Efectividad del ejercicio físico en la fatiga de pacientes con cáncer durante el tratamiento activo: revisión sistemática y metaanálisis

“…Estos resultados coinciden con lo descrito por otros autores en pacientes con cáncer de mama, así como con otras localizaciones, tales como próstata 35 y colon 44 . Sin embargo, se requiere de estudios adicionales que favorezcan el consenso en la literatura científica acerca de los efectos y seguridad del ejercicio físico en estas pacientes.…”

Is there an Association between Variants in Candidate Insulin Pathway Genes IGF-I, IGFBP-3, INSR, and IRS2 and Risk of Colorectal Cancer in the Iranian Population?

“…The previous investigations showed a great share of obesity and lifestyle factors such as diet, cigarette smoking, alcohol consumption, and physical inactivity, in individual's susceptibility to CRC (Giovannucci, 2001;Chapelle, 2004). The effect of these etiological factors on the risk of CRC mediated through the insulin (INS) pathway (Giovannucci, 1995;Lee et al, 2013). Various studies have linked diabetes and CRC risk (Yang et al, 2004;Nagel et al, 2006;Chung et al, 2008).…”

Effects of 8 Weeks of Resistance Training and IGF-1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats

“…Since IGFI injection causes hypoglycemia, primarily by stimulating peripheral glucose uptake (32), and IGFBPs buffer the acute hypoglycemic effect of IGF-I (33), Nishida et al suggested that the alterations in IGF-IGFBP-3 levels might be an adaptive response to prevent hypoglycemia following exercise training (7). According to previous studies, IGFBP-3 level might decrease (16), increase (16,18,34), and remain unchanged (35-37) after exercise training. In study of Santa et al, IGFBP-3 increased in response to resistance training and decreased in response to aerobic training (16).…”

“…Some studies have reported that acute resistance and endurance exercise increase serum IGF-1 concentrations but do not affect serum IGFBP-3 levels (2, 10, 11). Although several studies have examined changes in circulating level of IGF-1 and IGFBP-3 in response to exercise training, the results of such studies have been inconsistent (12)(13)(14)(15)(16)(17)(18)(19). Moreover, overexpression of IGF-1 and IGFBP-3 is thought to increase tumor size in colorectal cancer (9, 20).…”