Effects of a 15-amino-acid isoform of amyloid- β expressed by silkworm pupae on B6C3-Tg Alzheimer’s disease transgenic mice

Li, Si; Jin, Yihan; Wang, Chi; Chen, Jian; Yu, Wengong; Jin, Yongfeng; Lv, Zhengbing

doi:10.1016/j.jbiotec.2019.03.013

Cited by 5 publications

(7 citation statements)

References 25 publications

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“…In addition, Aβ(1-6) and Aβ (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) were used for the synthesis of 4-branched multiple-antigen peptides (MAP) 4 and subsequently administered to mice to develop Aβ specific antibodies [75]. Aβ (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) was also used in a cholera toxin B subunit/silkworm pupa vaccine [76] as well as in a yeast-based vaccine (Y-5A15) [77]. Aβ (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) was used in a combination vaccine (AV-1959R/AV-1980R) targeting both Aβ and tau [78].…”

Section: Peptide Epitopes Used In Aβ-vaccinesmentioning

confidence: 99%

“…The cholera toxin subunit-B (CTB) can be used as a powerful adjuvant to generate mucosal immunity and can enhance oral immune tolerance, due to its strong affinity to the monosialoganglioside (GM1) receptor, which is primarily located on mucosal epithelial cells. Thus, it was included in the formulation components of a vaccine composed of a CTB-Aβ(1-15) fused protein expressed in silkworm pupae, which was subsequently used for oral vaccination of transgenic mice [76].…”

Section: Miscellaneous Other Adjuvantsmentioning

confidence: 99%

“…To this end, a series of animal models for AD or other neurodegenerative diseases have been created/selected and used. Focusing on studies recently reported, various transgenic mouse models including APP/PS1 [71,77]/APPswe/PS1dE9 co-expressing human APP with Swedish mutation and exon-9-deleted presenilin [72,76,95], TauP301S of AD and Frontotemporal dementia phenotype [40,94,97], 3xTg-AD involving both Aβ and p-tau pathology [70,80,82,83,100], EAE/AD deriving from APP/PS1 crossed with EAE (experimental autoimmune encephalomyelitis) [84], Tau22/5xFAD developing both pathological Aβ and tau aggregates [78], PS19 [92], J20 [81], SNCA-OVX [43], B6SJL [111], Tg2576 as well as Tg-SwDI [79], and Tg4510 [34,96] have been employed. On the other hand, a few studies have employed Balb/C or C57/BL6 mice, so as to preliminarily estimate the vaccine capability of eliciting high antibody titers [73][74][75] (Table 2).…”

Section: Animal Models and Immunization Schemes Used In Recent Preclinical Studiesmentioning

confidence: 99%

“…A few studies used intradermal (i.d.) administration of DNA vaccine formulations [79,83] and one tested oral administration [76]. The total number of doses may also differ (Table 2).…”

Section: Animal Models and Immunization Schemes Used In Recent Preclinical Studiesmentioning

confidence: 99%

“…The majority of the reported protocols include at least three doses, with 4 to 6 doses usually selected [71][72][73][74][75]78,82,92,94,100,111]. However, as many as 14 doses [43] or an everyday oral administration protocol for a period of almost 9 months [76] have also been reported. 9 Amino acids shown with the one-letter code.…”

Section: Animal Models and Immunization Schemes Used In Recent Preclinical Studiesmentioning

confidence: 99%

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Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives

et al. 2021

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The development of peptide-based vaccines for treating human neurodegenerative diseases has been the eventual aim of many research endeavors, although no active immunotherapies have been approved for clinical use till now. A typical example of such endeavors is the effort to develop vaccines for Alzheimer’s disease based on the beta-amyloid peptide, which continues to be intensively investigated despite previous setbacks. In this paper, recent developments in peptide-based vaccines which target beta-amyloid as well as tau protein and α-synuclein are presented. Particular focus has been directed toward peptide epitopes and formulation systems selected/developed and employed to enhance vaccine efficacy and safety. Results from both, human clinical trials and animal preclinical studies conducted mainly in transgenic mice have been included. Future perspectives on the topic are also briefly discussed.

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Section: Peptide Epitopes Used In Aβ-vaccinesmentioning

confidence: 99%

Section: Miscellaneous Other Adjuvantsmentioning

confidence: 99%

Section: Animal Models and Immunization Schemes Used In Recent Preclinical Studiesmentioning

confidence: 99%

“…A few studies used intradermal (i.d.) administration of DNA vaccine formulations [79,83] and one tested oral administration [76]. The total number of doses may also differ (Table 2).…”

Section: Animal Models and Immunization Schemes Used In Recent Preclinical Studiesmentioning

confidence: 99%

Section: Animal Models and Immunization Schemes Used In Recent Preclinical Studiesmentioning

confidence: 99%

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Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives

et al. 2021

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A comprehensive review on the multifaceted applications of mulberry silkworm pupae: A sustainable resource

Beniwal,

Mahapatara,

Das

et al. 2024

Journal of Asia-Pacific Entomology

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Nutritional aspects and dietary benefits of “Silkworms”: Current scenario and future outlook

Mahanta

Komal²,

Samal³

et al. 2023

Front. Nutr.

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In the current scenario, it is estimated that by 2050, there will be an additional 2.5 billion people and a 70% increase in food demand. Crop yields are not increasing fast enough to support global needs, and world agriculture is facing several serious challenges. Therefore, insects can be a nutritious alternative to meet the ever-increasing food demand in the present and future. The majority of insect consumption occurs in developing countries, with approximately 1,900 insect species consumed worldwide. Food and feed derived from them are of high quality, have a high feed conversion ratio and emit a low level of greenhouse gases. Among insects silkworms are beneficial to humans, not only because of their high nutritional value, but also because of their several pharmacological properties. Silkworm eggs, larvae, and pupae contains high amount of proteins, oils, minerals, vitamins, and several other beneficial components which are nutritious as well as have positive effect on human health. Studies have shown that silkworm pupae protect the liver, enhance immunity, inhibit apoptosis, inhibit cancer, inhibit tumor growth, inhibit microbial growth, regulate blood glucose and blood lipids, and lower blood pressure. This review paper summerized the nutritional value of different life stages of silkworm, nutritional comparison of silkworm with the major human foods, and the effects of silkworm consumption on human health, thus ittargets to generate interest toward in sericulture and improve human health by using silkworm as a nutritious food and attain sustainability in food and nutritional security.

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Effects of a 15-amino-acid isoform of amyloid- β expressed by silkworm pupae on B6C3-Tg Alzheimer’s disease transgenic mice

Cited by 5 publications

References 25 publications

Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives

Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives

A comprehensive review on the multifaceted applications of mulberry silkworm pupae: A sustainable resource

Nutritional aspects and dietary benefits of “Silkworms”: Current scenario and future outlook

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