Effects of a 3-month weight-bearing and resistance exercise training on circulating osteogenic cells and bone formation markers in postmenopausal women with low bone mass

Pasqualini, Leonella; Ministrini, Stefano; Lombardini, Rita; Bagaglia, Francesco; Paltriccia, Rita; Pippi, Roberto; Collebrusco, Luca; Reginato, Elisa; Tomaro, Emilia Sbroma; Marini, Ettore; D’Abbondanza, Marco; Scarponi, Anna Maria; Feo, Pierpaolo De; Pirro, Matteo

doi:10.1007/s00198-019-04908-9

Cited by 35 publications

(26 citation statements)

References 38 publications

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“…Contrary to what we hypothesized, P1NP increased over the first 2 days in one calorie-restricted condition, as well as the control condition, and decreased following the resistance exercise bout in the control condition. Resistance training has previously been shown to increase P1NP in postmenopausal women (Pasqualini et al 2019 ), but we did not observe an increase 24 h after resistance exercise in this intervention. Further research is needed to replicate and confirm the influence of resistance exercise on bone markers in the calorie-restricted state.…”

Section: Discussioncontrasting

confidence: 84%

Caloric restriction induces anabolic resistance to resistance exercise

Murphy

Koehler

2020

Eur J Appl Physiol

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Purpose Weight loss can result in the loss of muscle mass and bone mineral density. Resistance exercise is commonly prescribed to attenuate these effects. However, the anabolic endocrine response to resistance exercise during caloric restriction has not been characterized. Methods Participants underwent 3-day conditions of caloric restriction (15 kcal kg FFM−1) with post-exercise carbohydrate (CRC) and with post-exercise protein (CRP), and an energy balance control (40 kcal kg FFM−1) with post-exercise carbohydrate (CON). Serial blood draws were taken following five sets of five repetitions of the barbell back squat exercise on day 3 of each condition. Results In CRC and CRP, respectively, growth hormone peaked at 2.6 ± 0.4 and 2.5 ± 0.9 times the peak concentrations observed during CON. Despite this, insulin-like growth factor-1 concentrations declined 18.3 ± 3.4% in CRC and 27.2 ± 3.8% in CRP, which was greater than the 7.6 ± 3.6% decline in CON, over the subsequent 24 h. Sclerostin increased over the first 2 days of each intervention by 19.2 ± 5.6% in CRC, 21.8 ± 6.2% in CRP and 13.4 ± 5.9% in CON, but following the resistance exercise bout, these increases were attenuated and no longer significant. Conclusion During caloric restriction, there is considerable endocrine anabolic resistance to a single bout of resistance exercise which persists in the presence of post-exercise whey protein supplementation. Alternative strategies to restore the sensitivity of insulin-like growth factor-1 to growth hormone need to be explored.

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Section: Discussioncontrasting

confidence: 84%

Caloric restriction induces anabolic resistance to resistance exercise

Murphy

Koehler

2020

Eur J Appl Physiol

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“…Interestingly, there was also a correlation found between COP cell number and muscle strength, perhaps indicating some level of crosstalk between muscle and bone. ( 61 ) A greater degree of arterial stiffening has also shown to be associated with the increase in COP cell numbers, possibly indicating a mechanistic link between osteoporosis and vascular disease. ( 55 )…”

Section: States Of Bone and Muscle Lossmentioning

confidence: 99%

Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Feehan

Kassem

Pignolo

et al. 2020

Journal of Bone and Mineral Research

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Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm‐like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. © 2020 American Society for Bone and Mineral Research (ASBMR).

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Section: Discussionmentioning

confidence: 99%

“…Physical activity is consider an important strategy to address the changes caused by menopause in women, improving their body composition, lipid profile, and quality of life (Gomez‐Tomas et al., 2018; Pasqualini et al, 2019). Therefore, several studies have included the combination of different types of physical activity in their interventions.…”

Section: Discussionmentioning

confidence: 99%

Effect of an intensive intervention on the increase of physical activity and the decrease of sedentary lifestyle in inactive postmenopausal

Alonso-Domínguez

Sánchez‐Aguadero

Llamas-Ramos

et al. 2021

Journal of Advanced Nursing

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Background During the transition to menopause, women experience different psychological, hormonal, and physical alterations that can affect their health. Physical activity is considered an important strategy in the prevention and control of such changes. Aim To evaluate the short‐term effect of an intensive intervention, based on a combined exercise programme using a Smartband, on the increase of physical activity and the decrease of sedentary lifestyle in postmenopausal and inactive women. Design Randomized clinical trial with two parallel groups. Methods In total, 100 postmenopausal and inactive women aged 45–70 years will be randomized to a control group or an intervention group. Both groups will be given a standardized advice about physical activity. The intervention group will carry out a supervised 12‐week programme of aerobic and muscle strengthening exercise; moreover, the women in this group will receive a Smartband to assist them in the intervention. The main result will be the increase of physical activity and the decrease of sedentary lifestyle, measured with an accelerometer for 1 week. This programme will be conducted by a nurse and a physiotherapist of the health centre. The study was approved by the Drug Research Ethics Committee of the Salamanca Health Service on 15 February 2019. The project was funded by the Autonomous Government of Castile and Leon and by the Carlos III Health Institute. Discussion Physical activity is an important strategy to consider when addressing the changes caused by menopause, although the current evidence shows that further studies should be carried out with longer intervention periods and new technologies. Impact This study will allow determining the effectiveness of the intensive intervention based on a combined programme of physical activity using a Smartband in postmenopausal and inactive women. Trials Registration ClinicalTrials.gov with identifying code NCT03872258.

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Effects of a 3-month weight-bearing and resistance exercise training on circulating osteogenic cells and bone formation markers in postmenopausal women with low bone mass

Cited by 35 publications

References 38 publications

Caloric restriction induces anabolic resistance to resistance exercise

Caloric restriction induces anabolic resistance to resistance exercise

Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Effect of an intensive intervention on the increase of physical activity and the decrease of sedentary lifestyle in inactive postmenopausal

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