Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial

Abstract

ClinicalTrials.gov Identifier: NCT01765517.

Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention

“…High attrition rates are unfortunately common for clinical trials done in Saudi Arabia, especially for new interventions. In one study on the 6 month effects of probiotics among Saudi T2DM patients, 150 participants were randomized to receive either placebo or probiotics at baseline, but only 61 completed the trial, as the concept of ingesting live bacteria was relatively unheard of in the region, therefore affecting compliance [35]. In the present study, participants of the intervention were able to successfully apply the lifestyle changes for one year, but the majority declined to continue for 6 months more, citing changes in priorities and other personal reasons that would prevent them from fully engaging in the program.…”

Effect of Lactobacillus paracasei HII01 on lipid profile and blood parameters in hypercholesterolemic patients: A preliminary study

“…31,32 Ecologic ® Barrier (Mixture of B. bifidum W23, B. lactis W52, L. acidophilus W37, L. brevis W63, L. casei W56, L. salivarius W24, Lactococcus lactis W19 and L. lactis W58) supplementation significantly reduced the blood endotoxin level and improved the lipid profile in diabetic patients. 33 Likely, the supplementation of the probiotic mixture (L. acidophilus T16, B. bifidum BIA-6, B. lactis BIA-6, and B. longum LAF-5) with or without prebiotics (maltodextrin) reduced the endotoxin level and improved inflammatory markers in hemodialysis patients. 34 The results of the current study supported that the supplementation of lyophilized L. paracasei HII01 amended the lipid profile in hypercholesterolemic patients.…”

A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics

“…Ecologic ® Barrier supplementation also reduced the FBG, insulin, HOMA-IR values, and inflammatory cytokines level in T2D patients. The results suggested that multi-strain probiotic preparation could be an adjuvant therapeutic agent to improve diabetic and cardiovascular-associated metabolic parameters [38].…”

“…Based on the randomized, placebo-controlled, double-blind studies [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] reviewed in the present article, the hypocholesterolemic effect of the probiotics was not significantly influenced by the diet. Studies reported based on the intervention of single-strain probiotic (E. faecium M-74 along with selenium [27]; Saccharomyces cerevisiae var.…”

“…Studies based on the intervention of multi-genus, multi-species, multi-strain (strains of same species) probiotic preparation has been reported with positive effect on lipid profile [24][25][26]28,[31][32][33][34][36][37][38][39]47,48], while several studies reported no effect of multi-genus and multi-species probiotic intervention on the lipid profile [55][56][57][58][59][60][61][62][63]. Even though intervention of Ecologic ® Barrier (B. bifidum W23, B. lactis W51, B. lactis W52, L. acidophilus W37, L. brevis W63, L. casei W56, L. salivarius W24, Lactococcus lactis W19 and W58) exhibit hypocholesterolemic effect on different subjects (individuals with T2D [38]; obese postmenopausal women [39]) with different intervention duration (six months [38]; 12 weeks [39]), dosage of probiotic mixture does not influence the cholesterol-lowering ability of the probiotic mixture.…”