Effects of a beta‐adrenergic agonist clenbuterol) on performance, carcase composition, hepatic microsomal mixed function oxidase and antibody production in female broilers treated with or without corticosterone

Takahashi, Kyoko; Akiba, Yukio; Horiguchi, Michiko

doi:10.1080/00071669308417572

Cited by 15 publications

(5 citation statements)

References 24 publications

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“…Additionally, there was a considerably enhanced carcass yield and significantly decreased abdominal weight percentage at 10 and 15 ppm doses of clenbuterol in other treated groups. Our obtained result was in agreement with those of previous studies [ 63 , 64 ]. They proved that b-adrenergic agonists could boost weight gain when added to feed, and the proportion of tissue fat is reduced [ 65 ].…”

Section: Discussionsupporting

confidence: 94%

Insight View on the Role of in Ovo Feeding of Clenbuterol on Hatched Chicks: Hatchability, Growth Efficiency, Serum Metabolic Profile, Muscle, and Lipid-Related Markers

Saleh

Alhotan

Alharthi

et al. 2021

Animals

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The present study aimed to assess the in ovo administration of clenbuterol on chick fertility, growth performance, muscle growth, myogenic gene expression, fatty acid, amino acid profile, intestinal morphology, and hepatic lipid-related gene expressions. In this study, 750 healthy fertile eggs from the local chicken breed Dokki-4 strain were analyzed. Fertile eggs were randomly divided into five experimental groups (150 eggs/3 replicates for each group). On day 14 of incubation, in addition to the control group, four other groups were established where 0.5 mL of worm saline (30 °C) was injected into the second group of eggs. In the third, fourth, and fifth groups, 0.5 mL of worm saline (30 °C), 0.9% of NaCl, and 10, 15, and 20 ppm of clenbuterol were injected into the eggs. Results suggested that clenbuterol increased growth efficiency up to 12 weeks of age, especially at 15 ppm, followed by 10 ppm, decreased abdominal body fat mass, and improved hatchability (p < 0.01). Clenbuterol also modulated saturated fatty acid levels in the breast muscles and improved essential amino acids when administered at 10 and 15 ppm. Additionally, clenbuterol at 15 ppm significantly decreased myostatin gene expression (p < 0.01) and considerably increased IGF1r and IGF-binding protein (IGFBP) expression. Clenbuterol administration led to a significant upregulation of hepatic PPARα, growth hormone receptor, and Lipoprotein lipase (LPL) mRNA expression with a marked decrease in fatty acid synthase (FAS) and sterol regulatory element-binding protein 1 (SREBP-1c) expression. In conclusion, the current study revealed that in ovo injection of clenbuterol showed positive effects on the growth of hatched chicks through reduced abdominal fat deposition, improved intestinal morphology, and modulation of hepatic gene expressions in myogenesis, lipogenesis, and lipolysis.

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Section: Discussionsupporting

confidence: 94%

Insight View on the Role of in Ovo Feeding of Clenbuterol on Hatched Chicks: Hatchability, Growth Efficiency, Serum Metabolic Profile, Muscle, and Lipid-Related Markers

Saleh

Alhotan

Alharthi

et al. 2021

Animals

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“…These data indicate that clenbuterol treatment suppresses humoral immune response in sheep. However, Takahashi et al (1993) could find no evidence of an effect of short-term (14 d ) clenbuterol treatment on hemagglutination of sheep red blood cells in chickens. It is difficult to draw comparisons from the two studies because of differences in species, immunogens, length of treatment, and immune response measurements.…”

Section: Resultsmentioning

confidence: 83%

Suppression of immune response in lambs during treatment with the beta-adrenergic agonist clenbuterol.

Spencer

Oliver

1996

Journal of Animal Science

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The effect of the beta-adrenergic agonist clenbuterol on immune function was examined in sheep. Twenty ewe lambs were housed indoors, with food and water available on an ad libitum basis, and immunized against somatostatin (SRIF) using a SRIF-ovalbumin conjugate. Ten of the lambs were also treated with clenbuterol (400 micrograms/kg) each day; 10 controls were not treated. After 5 wk of treatment (with booster injections of the SRIF conjugate each fortnight), the lambs were bled and then slaughtered for carcass composition. The lambs that received immunization alone produced significant antibody titers against SRIF, whereas 9 of the 10 clenbuterol-treated lambs produced no significant, specific antibody response. There was no effect of clenbuterol treatment on liver, thymus, spleen, kidney, kidney fat, or biceps femoris weight compared with those lambs that were only immunized. These results indicate that treatment with clenbuterol may inhibit humoral antibody response to infection.

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“…Moreover, corticosterone, which is a major glucocorticoid in chickens, impairs insulin signalling in the liver and skeletal muscle, resulting in insulin resistance (Dupont et al 1999). The administration of corticosterone, in addition, increases adipose tissue accretion (Takahashi et al 1993) with hyperlipidaemia (Malheiros et al 2003) and stimulates hepatic glyconeogenesis (Webster, 2003). Thus, this hormone, which affects insulin action and energy source distribution, may be associated with the ALA-induced metabolic response of chickens.…”

Section: Insulin Sensitivity: Lipoic Acid: Lipolysismentioning

confidence: 99%

Effects of dietary lipoic acid on plasma lipid,in vivoinsulin sensitivity, metabolic response to corticosterone andin vitrolipolysis in broiler chickens

Hamano¹

2006

Br J Nutr

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The present study consisted of two experiments. The first experiment was conducted to determine the effects of lipoic acid (ALA; 200 mg/kg) on plasma lipids and insulin sensitivity of whole-body tissue in broilers treated with or without corticosterone (5 mg/kg). Chickens received these agents from 2 to 5 weeks of age in a 2 £ 2 factorial arrangement. Thereafter, from 39 to 42 d of age, insulin sensitivity was estimated using the euglycaemic and hyperinsulinaemic clamp technique. Experiment 2 examined whether ALA supplementation for 5 weeks (400 mg/kg) would alter short-chain acyl-CoA concentration in the liver and in vitro lipolysis of an adipose tissue slice, in relation to noradrenaline (10 mM) supplementation. In experiment 1, ALA had no effect on the corticosterone-induced negative growth performance. ALA lowered plasma glucose level (P,0·05) and, in contrast, increased triacylglycerol level (P,0·05). These responses to ALA had, however, no interrelationship with corticosterone. The rate of glucose uptake of whole-body tissue was enhanced in the ALA-fed chickens (P, 0·05), regardless of corticosterone treatment. In experiment 2, ALA increased only the plasma free glycerol concentration (P,0·01). The rate of free glycerol release from an adipose tissue slice was enhanced by ALA feeding (P, 0·05) but was not affected by noradrenaline supplementation. This study suggests that ALA stimulates the insulin sensitivity of tissues regardless of corticosterone-dependent metabolism and that the ALA-induced fatty acid metabolism of broilers differs between the liver and adipose tissue.

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Effects of a beta‐adrenergic agonist clenbuterol) on performance, carcase composition, hepatic microsomal mixed function oxidase and antibody production in female broilers treated with or without corticosterone

Cited by 15 publications

References 24 publications

Insight View on the Role of in Ovo Feeding of Clenbuterol on Hatched Chicks: Hatchability, Growth Efficiency, Serum Metabolic Profile, Muscle, and Lipid-Related Markers

Insight View on the Role of in Ovo Feeding of Clenbuterol on Hatched Chicks: Hatchability, Growth Efficiency, Serum Metabolic Profile, Muscle, and Lipid-Related Markers

Suppression of immune response in lambs during treatment with the beta-adrenergic agonist clenbuterol.

Effects of dietary lipoic acid on plasma lipid,in vivoinsulin sensitivity, metabolic response to corticosterone andin vitrolipolysis in broiler chickens

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